Results 91 to 100 of about 42,909 (288)

Involvement of advanced glycation end products in the pathogenesis of diabetic complications: the protective role of regular physical activity [PDF]

, 2008
Advanced glycation end products (AGEs) may play an important role in the pathogenesis of chronic diabetic complications and in the natural process of biological aging.
Appell, H.J., Duarte, José Alberto, Magalhães, Pedro   +2 more
core   +1 more source

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

Animal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Fuad A. Iraqi   +3 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Combined anti-ages and antioxidant activities of different solvent extracts of Solanum elaeagnifolium Cav (Solanacea) fruits during ripening and related to their phytochemical compositions [PDF]

Oxidative stress and advanced glycation end products (AGEs) are known as key factors for the development of diabetic complications such as retinopathy, cataract as well as atherosclerosis and neurodegenerative diseases, including Alzheimer’s diseases. In
Derbré, Séverine, Houda, Mejri, Jedy, Ahmed, Legault, Jean, Limam, Ferid, Richomme, Pascal, Saidani-Tounsi, Moufida, Tlili, Nizar   +7 more
core   +1 more source

Multimodal optical diagnostics of the microhaemodynamics in upper and lower limbs [PDF]

, 2019
The introduction of optical non-invasive diagnostic methods into clinical practice can substantially advance in the detection of early microcirculatory disorders in patients with different diseases.
Dremin, Viktor V., Dunaev, Andrey V., Goltsov, Alexey, Makovik, Irina N., Rafailov, Edik U., Sokolovski, Sergei G., Zherebtsov, Evgeny A., Zherebtsova, Angelina I.   +7 more
core   +4 more sources

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, EarlyView.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify noninvasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, for the Lupus Nephritis Classification Steering Committee   +11 more
wiley   +1 more source

The natural history of periodontal disease—Part 2: In populations with access to dental care: The Studies of Health in Pomerania (SHIP)

Periodontology 2000, EarlyView., 2023
Abstract In this descriptive analysis of the 21‐year follow‐up data from the SHIP‐START cohort and the 7‐year follow‐up data from the SHIP‐TREND cohort, we report the progression of clinical attachment levels (CAL), age effects on CAL change, and a detailed description of CAL progression and remission. At baseline, 4307 and 4420 persons participated in
Thomas Kocher, Peter Meisel, Reiner Biffar, Henry Völzke, Birte Holtfreter   +4 more
wiley   +1 more source

Altered Cell-surface Receptor Levels Result from Fructose Advanced Glycation End Product-Induced Inflammation [PDF]

, 2014
Objective: As a result of the heightened reactivity fructose demonstrates compared to glucose and our current knowledge of glucose advanced glycation end-products, the aim of this research was to further elucidate the proinflammatory pathways involved in
Blackley, Regina, Lull, Melinda E., Stryker, Matthew   +2 more
core   +1 more source

Protein modification and maintenance systems as biomarkers of ageing [PDF]

, 2015
Changes in the abundance and post-translational modification of proteins and accumulation of some covalently modified proteins have been proposed to represent hallmarks of biological ageing.
Friguet, Bertrand, Gonos, Efstathios S, Libert, Claude, Petropoulos, Isabelle, Santos, Alexander Navarrete, Simm, Andreas, Vanhooren, Valerie, Voutetakis, Konstantinos   +7 more
core   +3 more sources

Immunologic Profiling Suggests an Association Between Treg Cell Dysfunction and Pain in Knee Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Pain is the hallmark symptom of osteoarthritis (OA), and its biologic drivers remain poorly understood. Although the role of innate immunity in OA has been extensively studied, the involvement of adaptive immunity, in particular Treg cells, is not well understood.
Marie Binvignat, Johanna Dubois, Maria Marco Salvador, Paul Stys, Fabien Pitoiset, Alexandra Roux, Michèle Sastre, Signe Hassler, Roberta Lorenzon, Claire Ribet, Vanessa Mhanna, Hélène Vantomme, Leslie Adda, Pierre Barennes, Nicolas Coatnoan, Kenz Le Gouge, Caroline Aheng, Alice Courties, Lise Minssen, Atul J. Butte, Adrien Six, Michelle Rosenzwajg, Nicolas Tchitchek, Francis Berenbaum, David Klatzmann, Encarnita Mariotti‐Ferrandiz, Jérémie Sellam   +26 more
wiley   +1 more source