Results 91 to 100 of about 63,117 (342)

The effects of advanced glycation end products (AGEs) on dermal wound healing and scar formation: a systematic review

Scars, Burns & Healing, 2016
Introduction: With ageing, the skin gradually loses its youthful appearance and functions like wound healing and scar formation. The pathophysiological theory of Advanced Glycation End products (AGEs) has gained traction during the last decade.
Lennert Van Putte, Sofie De Schrijver, P. Moortgat   +2 more
semanticscholar   +1 more source

Elevated hemoglobin glycation index identify non-diabetic individuals at increased risk of kidney dysfunction [PDF]

, 2017
Hemoglobin glycation index (HGI), calculated as the difference between the observed value of HbA1 and the predicted HbA1c based on plasma glucose concentration, is a measure of the individual tendency toward non-enzymatic hemoglobin glycation which has ...
Andreozzi, F, Fiorentino, Tv, Marini, Ma, Perticone, F, Sciacqua, A, Sesti, G, Succurro, E   +6 more
core   +2 more sources

An investigation of acute effects at various doses of malathion on glucose homeostasis and insulin resistance in rat liver, pancreas and serum [PDF]

, 2020
Objective. This study investigates acute effects of various doses of Malathion on glucose homeostasis and insulin resistance in rat. Methods. Rats were randomly divided into four groups of 6 animals each. Corn oil was given orally to Group 1.
Ekremoğlu, Murat, Pasaoğlu, Hatice, Pasaoğlu, Özge Tuğce, Severcan, Çınar, Şen, Bayram   +4 more
core   +3 more sources

Conductive Microneedles Loaded With Polyphenol‐Engineered Exosomes Reshape Diabetic Neurovascular Niches for Chronic Wound Healing

Advanced Science, EarlyView.
This study establishes a bio‐electroceutical interface by synergizing engineered exosome‐derived biological signals with electroconductive microneedle‐delivered electrical cues, achieving dual‐pathway reprogramming of the diabetic neurovascular niches and accelerating wound healing. Abstract Diabetic wound healing remains a major clinical challenge due
Di Liu, Jingxian Gao, Xueling Wu, Xinxin Hao, Wenxiu Hu, Lu Han   +5 more
wiley   +1 more source

Allicin Alleviates Diabetes Mellitus by Inhibiting the Formation of Advanced Glycation End Products

Molecules, 2022
Advanced glycation end products (AGEs) cause damage to pancreatic β-cells and trigger oxidative stress and inflammation, which promotes the development and progression of diabetes and its complications. Therefore, it is important to inhibit the formation
Linzehao Li, Qinghe Song, Xiandang Zhang, Yan Yan, Xiaolei Wang   +4 more
doaj   +1 more source

Acetoacetate promotes the formation of fluorescent advanced glycation end products (AGEs) [PDF]

Journal of Biomolecular Structure and Dynamics, 2016
Acetoacetate (AA) is an important ketone body, which produces reactive oxygen species (ROS). Advanced glycation end products (AGEs) are defined as final products of glycation process whose production is influenced by the levels of ROS. The accumulation of AGEs in the body contributes to pathogenesis of many diseases including complications of diabetes,
Mansour Ghaffari-Moghaddam, Zohre Aghashiri, Ali Akbar Moosavi-Movahedi, Mostafa Khajeh, Mousa Bohlooli, Nader Sheibani   +5 more
openaire   +3 more sources

Protective role of vitamin B6 (PLP) against DNA damage in Drosophila models of type 2 diabetes [PDF]

, 2018
Growing evidence shows that improper intake of vitamin B6 increases cancer risk and several studies indicate that diabetic patients have a higher risk of developing tumors.
MF Fenech, M Fenech, F Mitelman, A Aguilera, SF Bunting, SJ Duthie, MJ Shrubsole, YI Kim, JB Mason, CD Cantarella, R Percudani, R Percudani, ML Salvo di, H Hellmann, AA Booth, P Bilski, SA Denslow, BN Ames, L Galluzzi, S Mocellin, L Galluzzi, B Gylling, A Marzio, P Kanellis, SC Lee, M Brownlee, D Bonnefont-Rousselot, Y Hinokio, MT Goodarzi, E Tatsch, P Graham, RS Garofalo, RW Alfa, LP Musselman, SN Thompson, R Ugrankar, R Bohni, M Tatar, JM Murillo-Maldonado, M Lorenzi, A Rezabakhsh, SE Polo, JP Madigan, PA Jeggo, C Merigliano, H Vlassara, H Stopper, N Schupp, S Golbidi, EA Muellenbach, J Colombani, AT Haselton, SK Kim, G Lee, EJ Rulifson, SJ Broughton, T Ikeya, M Fraser, S Nakamura, M Pischetsrieder, S Nakamura, J Blasiak, PT Clayton, M Okada, JE Leklem, HJ Ahn, WA Nix, M Gatti, S Bonaccorsi, FJ Diaz-Benjumea   +69 more
core   +2 more sources

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source

Dietary Advanced Glycation End Products: Their Role in the Insulin Resistance of Aging

Cells, 2023
Insulin resistance (IR) is commonly observed during aging and is at the root of many of the chronic nontransmissible diseases experienced as people grow older. Many factors may play a role in causing IR, but diet is undoubtedly an important one. Whether it is total caloric intake or specific components of the diet, the factors responsible remain to be ...
Manuel Portero-Otin, M. Pia de la Maza, Jaime Uribarri   +2 more
openaire   +3 more sources

Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms [PDF]

, 2018
Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes.
Guzik, Tomasz J., Petrie, John R., Touyz, Rhian M.   +2 more
core   +1 more source