Results 131 to 140 of about 42,909 (288)

Receptor for Advanced Glycation End Products and Age-Related Macular Degeneration

Investigative Opthalmology & Visual Science, 2004
Advanced glycation end products (AGE) exacerbate disease progression through two general mechanisms: modifying molecules and forming nondegradable aggregates, thus impairing normal cellular/tissue functions, and altering cellular function directly through receptor-mediated activation.
Kimberly A, Howes, Yang, Liu, Joshua L, Dunaief, Ann, Milam, Jeanne M, Frederick, Alexander, Marks, Wolfgang, Baehr   +6 more
openaire   +2 more sources

Impact of Denosumab Adherence on Renal Function and Mortality Rates in Type 2 Diabetes Patients With Osteoporosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Type 2 diabetes mellitus (T2DM) is associated with an increased risk of osteoporosis and fractures, and denosumab, a non‐kidney‐excreted antiresorptive medication, represents a viable alternative to bisphosphonates for osteoporosis treatment in patients with T2DM. This study aimed to investigate the association among denosumab adherence, renal
Yu‐Chuan Chang, Jian‐Chih Chen, Sung‐Yen Lin, Kun‐Der Lin, Pei‐Shan Ho, Chung‐Hwan Chen, Yin‐Chih Fu, Tien‐Ching Lee   +7 more
wiley   +1 more source

Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) is a life‐threatening stroke subtype that lacks effective drug therapy. In the context of ICH, neuroinflammation, and ferroptosis are key contributors to secondary brain injury. In this study, we assessed the neuroprotective effects of matrine (MAT) and its mechanism of action involving the HMGB1/RAGE axis in an ...
Pan‐Di Chen, Tao‐Tao Shi, Dan‐Yang Hu, Xiao‐Na Su, Jian‐Xiang Jin, Mao‐Song Chen, Hao Wang, Wei Chen   +7 more
wiley   +1 more source

Sensory profile of cats with potential pain‐related diabetic neuropathy

Veterinary Record, EarlyView.
Abstract Background Diabetes mellitus (DM) can cause peripheral neuropathy. This study aimed to evaluate sensory function by measuring the mechanical nociceptive thresholds (MNT) and diffuse noxious inhibitory control (DNIC) of cats with diabetes mellitus (DMcats).
Hélène L. M. Ruel, Vanessa Bruneau, Berenice Conversy, Sabrine Marangoni, Paulo V. Steagall   +4 more
wiley   +1 more source

Role of Advanced Glycation End Products and Mitohormesis in Cancer Development and Progression

Antioxidants
Advanced glycation end products (AGEs) are molecules formed via non-enzymatic reactions between reactive dicarbonyls and macromolecules, including proteins, lipids, or DNA.
Donghyun Kim, Kyung-Nam Choi, Jong-In Park, Eun-Hye Kim, Arshad Majid, Ok-Nam Bae   +5 more
doaj   +1 more source

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian, Lena Palaniyappan, Theodore T. Kolivakis, Howard C. Margolese   +3 more
wiley   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

The possible therapeutic role of advanced glycation end-product inhibitors in ischemic stroke

Brain Research Bulletin
The advanced glycation end-products (AGEs) are toxic molecules result from non-enzymatic interactions of sugar with lipids or proteins. AGEs promote the generation of reactive oxygen species that induce the release of pro-inflammatory cytokines, and ...
Nada H. Aljarba, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Mustafa M. Shokr, Marios Papadakis, Athanasios Alexiou, Mubarak Alruwaili, Mohammed Alrouji, Mohammed S. Alshammari, Gaber El-Saber Batiha   +9 more
doaj   +1 more source

Diabetic kidney disease, biomarkers, and finerenone

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure worldwide, is associated with an increased risk of cardiovascular disease (CVD). A complex pathobiology involving hemodynamic, metabolic, and immune dysregulation promotes inflammatory and fibrotic pathways that contribute to kidney disease progression and CVD in individuals ...
Ashish Verma, Ashish Upadhyay
wiley   +1 more source