Results 1 to 10 of about 585,342 (345)

Novel Therapeutic Targets in Liver Fibrosis

Frontiers in Molecular Biosciences, 2021
Liver fibrosis is end-stage liver disease that can be rescued. If irritation continues due to viral infection, schistosomiasis and alcoholism, liver fibrosis can progress to liver cirrhosis and even cancer.
Jinhang Zhang, Qinhui Liu, Jinhan He, Jinhan He, Yanping Li   +4 more
doaj   +1 more source

Safety and effectiveness of all-oral and injectable-containing, bedaquiline-based long treatment regimen for pre-XDR tuberculosis in Vietnam

Frontiers in Pharmacology, 2022
Background: The World health organization (WHO) recently recommended standardized all-oral shorter regimens for rifampicin resistant Tuberculosis (RR-TB).
Thi Mai Phuong Nguyen, Binh Hoa Nguyen, Thi Thanh Thuy Hoang, Hoang Anh Nguyen, Dinh Hoa Vu, Mai Hoa Nguyen, Bao Ngoc Nguyen, Tom Decroo, Viet Nhung Nguyen   +8 more
doaj   +1 more source

Study of prescribing errors of two different prescription systems: pre-printed prescription from historical medication and hand-written prescription [PDF]

Pharmaceutical Sciences Asia, 2022
A retrospective observational study of 1,160 prescriptions with prescribing errors from a large academic hospital in Thailand from 2014 to 2017. The aims of this study are to explore the proportion of prescribing error from pre-printed prescriptions and ...
Nisa Sae-lim, Ploylarp Lertvipapath
doaj   +1 more source

Inhibition of 5-Lipoxygenase in Hepatic Stellate Cells Alleviates Liver Fibrosis

Frontiers in Pharmacology, 2021
Background and Purpose: Activation of hepatic stellate cells (HSC) is a central driver of liver fibrosis. 5-lipoxygenase (5-LO) is the key enzyme that catalyzes arachidonic acid into leukotrienes.
Shiyun Pu, Shiyun Pu, Yanping Li, Qinhui Liu, Xu Zhang, Lei Chen, Lei Chen, Rui Li, Rui Li, Jinhang Zhang, Jinhang Zhang, Tong Wu, Tong Wu, Qin Tang, Qin Tang, Xuping Yang, Xuping Yang, Zijing Zhang, Zijing Zhang, Ya Huang, Ya Huang, Jiangying Kuang, Jiangying Kuang, Hong Li, Hong Li, Min Zou, Wei Jiang, Jinhan He, Jinhan He   +28 more
doaj   +1 more source

Apigenin reduces the suppressive effect of exosomes derived from irritable bowel syndrome patients on the autophagy of human colon epithelial cells by promoting ATG14

World Journal of Surgical Oncology, 2023
Background Inflammatory bowel disease (IBS) is a chronic disorder of the gastrointestinal tract. Exosomes have been involved in various pathological processes including IBS. Apigenin has been reported to suppress inflammatory bowel disease (IBS). However,
Rui Fu, Saiyue Liu, Mingjin Zhu, Jiajie Zhu, Mingxian Chen   +4 more
doaj   +1 more source

Population Pharmacokinetics and Dose Optimization of Ceftazidime and Imipenem in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Pharmaceutics, 2021
Background: Ceftazidime and imipenem have been increasingly used to treat Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) due to their extended-spectrum covering Pseudomonas aeruginosa.
Thu-Minh Nguyen, Thu-Hue Ngo, Anh-Quan Truong, Dinh-Hoa Vu, Dinh-Chi Le, Ngan-Binh Vu, Tuyet-Nga Can, Hoang-Anh Nguyen, Thu-Phuong Phan, Françoise Van Bambeke, Céline Vidaillac, Quy-Chau Ngo   +11 more
doaj   +1 more source

Drug-Related Deaths in China: An Analysis of a Spontaneous Reporting System

Frontiers in Pharmacology, 2022
Background: Adverse drug reactions with an outcome of death represent the most serious consequences and are inherently important for pharmacovigilance.
Haona Li, Jianxiong Deng, Peiming Yu, Xuequn Ren   +3 more
doaj   +1 more source

Drug-Induced Severe Cutaneous Adverse Reactions: Insights Into Clinical Presentation, Immunopathogenesis, Diagnostic Methods, Treatment, and Pharmacogenomics

Frontiers in Pharmacology, 2022
SCARs are rare and life-threatening hypersensitivity reactions. In general, the increased duration of hospital stays and the associated cost burden are common issues, and in the worst-case scenario, they can result in mortality.
Therdpong Tempark, Therdpong Tempark, Shobana John, Shobana John, Pawinee Rerknimitr, Pawinee Rerknimitr, Patompong Satapornpong, Patompong Satapornpong, Chonlaphat Sukasem, Chonlaphat Sukasem, Chonlaphat Sukasem, Chonlaphat Sukasem, Chonlaphat Sukasem, Chonlaphat Sukasem   +13 more
doaj   +1 more source

PEG-Derivatized Dual-Functional Nanomicelles for Improved Cancer Therapy

Frontiers in Pharmacology, 2019
Polymeric micelles have attracted considerable attention for effective delivery of poorly water-soluble cancer drugs. Polyethylene glycol (PEG), which has been approved for human use by the US Food and Drug Administration, is the most commonly used ...
Yanping Li, Ting Zhang, Qinhui Liu, Jinhan He, Jinhan He   +4 more
doaj   +1 more source

Study of adverse drug reactions of atypical antipsychotic drugs in the department of psychiatry in a tertiary care hospital of Assam

Open Journal of Psychiatry and Allied Sciences, 2017
Objective: To monitor the adverse drug reactions (ADRs) of atypical antipsychotic drugs in the outpatient department (OPD) of psychiatry in Silchar Medical College and Hospital (SMCH) of Assam, and also to find out the causality and severity of ADRs ...
Pinaki Chakravarty, Parthajyoti Neog, Babul Dewan   +2 more
doaj   +1 more source