Results 81 to 90 of about 132,244 (301)

Affective Domain as the Main Foundation for Meaningful Learning in the Age of Mediamorphosis

open access: yes, 2023
The affective domain is vital for achieving meaningful learning and happiness.  However, this domain is difficult to assess due to its complexity and relative measurement.
Mohammed Zabidi, Ahmad Fakhrurrazi   +3 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Affective education in the primary phase: some comparative perspectives [PDF]

open access: yes
The aim of this work was to look at the contribution primary education makes to the affective development of students. Using the term 'affective education' to refer to all the planned learning experiences provided for this purpose, a study was conducted ...
Vasileiou, Kanella
core  

Play with emotion : affect-driven reinforcement learning [PDF]

open access: yes, 2022
This paper introduces a paradigm shift by viewing the task of affect modeling as a reinforcement learning (RL) process. According to the proposed paradigm, RL agents learn a policy (i.e.
Khalifa, Ahmed   +4 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Professionalism among paramedic students: achieving the measure or missing the mark?

open access: yesAdvances in Medical Education and Practice, 2017
L Michael Bowen, Brett Williams, Luke Stanke Department of Community Emergency Health and Paramedic Practice, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia Background: Professionalism is a pillar of ...
Bowen LM, Williams B, Stanke L
doaj  

Examining the affective domain in physical education [PDF]

open access: yes
UNESCO (2015) outlined ambitious intentions for a broad and holistic Physical Education (PE) curriculum that facilitated student growth across four learning domains (physical, cognitive, social, and affective). However, much of what educators do tends to
Patz, William
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Six types of psychological contracts: their affective commitment and employability. [PDF]

open access: yes
The purpose of this study is to identify a variety of employment relationships based upon an economy-wide, representative sample. We turn to psychological contract studies examining different types of psychological contracts.
Janssens, Maddy   +2 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

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