Results 111 to 120 of about 2,297,328 (417)

A Novel Purification Process of Sardine Lipases Using Protein Ultrafiltration and Dye Ligand Affinity Chromatography

Biophysica
Protein purification is often performed for various applications. However, enzyme purification processes typically involve multiple steps that reduce yield and increase production costs.
Juan Antonio Noriega-Rodríguez, Armando Tejeda-Mansir, Hugo Sergio García   +2 more
doaj   +1 more source

An affinity for motifs [PDF]

Nature Methods, 2011
Antibodies targeting short sequence motifs found in multiple proteins can be used in a discovery array–based platform.
openaire   +2 more sources

Affine OneMax

Proceedings of the Genetic and Evolutionary Computation Conference Companion, 2021
An extended two-page abstract of this work will appear in 2021 Genetic and Evolutionary Computation Conference Companion (GECCO '21 Companion)
openaire   +2 more sources

HELIN Cataloging Affinity Group minutes for 12/08/10

, 2010
Minutes of the Cataloging Affinity Group of the HELIN Consortium for December ...
HELIN Consortium. Cataloging Affinity Group
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

HELIN Serials Affinity Group minutes for 03/06/12

, 2012
Minutes of the Serials Affinity Group of the HELIN Consortium for March ...
HELIN Consortium. Serials Affinity Group
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

CSF Aquaporin-4 levels in controls and in idiopathic normal pressure hydrocephalus before and after shunt surgery

Fluids and Barriers of the CNS
Background Aquaporin-4 (AQP4) is crucial for brain fluid regulation and glymphatic system function. Idiopathic normal pressure hydrocephalus (INPH) is characterized by impaired CSF flow and is treated with shunt surgery.
Johan Eriksson De Ryst, Sofia Bergström, Sara Mravinacova, David Bäckström, Sara Qvarlander, Anna Månberg, Anders Eklund, Jan Malm   +7 more
doaj   +1 more source

Antibody Fragments and Their Purification by Protein L Affinity Chromatography

Antibodies, 2015
Antibodies and related proteins comprise one of the largest and fastest-growing classes of protein pharmaceuticals. A majority of such molecules are monoclonal antibodies; however, many new entities are antibody fragments.
Gustav Rodrigo, Mats Gruvegård, James M. Van Alstine   +2 more
doaj   +1 more source

Visualizing Antibody Affinity Maturation in Germinal Centers

Science, 2016
Diversity reigns in antibody responses During the course of an immune response, B cells specific for an invading pathogen divide. The antibodies they produce increase in affinity via somatic mutation in specialized lymph node structures called germinal ...
J. Tas, L. Mesin, G. Pasqual, S. Targ, Johanne T. Jacobsen, Y. Mano, Casie S. Chen, J. Weill, C. Reynaud, E. Browne, M. Meyer-Hermann, G. Victora   +11 more
semanticscholar   +1 more source