Results 11 to 20 of about 207,426 (323)

Interleukin-6 receptor blockade suppresses subretinal fibrosis in a mouse model [PDF]

International Journal of Ophthalmology, 2014
AIM:To determine the involvement of the interleukin (IL)-6 with the development of experimental subretinal fibrosis in a mouse model.METHODS:Subretinal fibrosis was induced by subretinal injection of macrophage-rich peritoneal exudate cells and the local
Wei Cui, Han Zhang, Zhe-Li Liu
doaj   +1 more source

Age-Related Macular or Retinal Degeneration?

Medicina, 2023
Age-related macular degeneration (AMD) is an eye disease that leads to progressive vision loss. Its prevalence has been increasing due to population aging.
Michalina Gałuszka, Dorota Pojda-Wilczek, Izabella Karska-Basta   +2 more
doaj   +1 more source

Age-related macular degeneration: an overview

Revista Brasileira de Oftalmologia, 2021
Age-related macular degeneration is the most important cause of irreversible vision loss in the elderly and has been considered a severe public health problem. Current treatments have only been successful in delaying the loss of central vision.
Rogil José de Almeida Torres, Ana Lúcia dos Anjos Ferreira   +1 more
doaj   +1 more source

Effect of High-Dose Intravitreal Aflibercept, 8 mg, in Patients With Neovascular Age-Related Macular Degeneration

JAMA ophthalmology, 2023
This randomized clinical trial assesses the safety and efficacy of aflibercept, 8 mg, in patients with neovascular age-related macular degeneration.
C. Wykoff, David M. Brown, Kim Reed, Alyson J. Berliner, Adam T. Gerstenblith, A. Breazna, P. Abraham, Jordana Fein, Karen W. Chu, W. Clark, S. Leal, T. Schmelter, B. Hirshberg, G. Yancopoulos, R. Vitti, S. Alam, Astrid Gonzalez Ramos, D. Alfaro, S. Adrean, J. Payne, H. Brooks, M. Chittum, D. Callanan, R. Paylor, C. Chan, J. Allen, N. Chaudhry, Margaret Chang, San-Ni Chen, W. Bridges, J. Dooner, W. Solley, A. Emanuelli, R. Teed, Scott Friedman, N. Moinfar, Ghassan Ghorayeb, Shelly T. Lee, D. Berinstein, Mitchell Goff, H. Reiser, Amir H. Guerami, E. Ashmore, C. Hagedorn, Jose Martinez, Paul Hahn, Juner Colina-Biscotto, Vrinda S. Hershberger, B. Joondeph, E. Kruger, J. S. Bryan, Michael Lee, M. Chiu, C. Roybal, F. Wyant, J. Luu, M. Byun, James D. Palmer, M. Wieland, J. Pearlman, Evan Berger, J. Pitcher, R. Rathod, O. Punjabi, L. Feiner, H. Ramkumar, Steven G. Lin, Rahul Reddy, R. Dreyer, N. Steinle, V. Sheth, D. Faber, Cameron Stone, R. Engstrom, R. Wirthlin, M. El-Gasim, R. Parnes   +76 more
semanticscholar   +1 more source

Oxidative Stress and Antioxidants in Age-Related Macular Degeneration

Antioxidants, 2023
Oxidative stress plays a crucial role in aging-related eye diseases, including age-related macular degeneration (AMD), cataracts, and glaucoma. With age, antioxidant reparative capacity decreases, and excess levels of reactive oxygen species produce ...
N. Kushwah, Kiran Bora, M. Maurya, Madeline C. Pavlovich, Jing Chen   +4 more
semanticscholar   +1 more source

Nanotechnology for Age-Related Macular Degeneration

Pharmaceutics, 2021
Age-related macular degeneration (AMD) is a degenerative eye disease that is the leading cause of irreversible vision loss in people 50 years and older.
Bo Yang, Ge Li, Jiaxin Liu, Xiangyu Li, Shixin Zhang, Fengying Sun, Wenhua Liu   +6 more
doaj   +1 more source

Complement C3 variant and the risk of age-related macular degeneration [PDF]

, 2007
Background: Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors.
Armbrecht, AM, Bird, AC, Clayton, DG, Deary, IJ, Dhillon, B, Genetic Factors AMD Study G, Hayward, C, Khan, JC, Matharu, BK, Moore, AT, Morgan, J, Redmond, E, Sepp, T, Shahid, H, Thurlby, DA, Wright, AF, Yates, JRW   +16 more
core   +1 more source

Y chromosome mosaicism is associated with age-related macular degeneration [PDF]

, 2019
Acknowledgements The authors thank Sudha K. Iyengar, Rob Igo and Alberto H. Santana (Case Western Reserve University, Cleveland, Ohio, USA) as well as the IAMDGC (http://eaglep.case.edu/iamdgc_web/) for providing the raw probe intensities.
on behalf of the International Age-related Macular Degeneration Genomics Consortium (IAMDGC)
core   +1 more source

Prevalence of Age-Related Macular Degeneration in the US in 2019.

JAMA ophthalmology, 2022
Importance Age-related macular degeneration (AMD) is a leading cause of vision loss and blindness. AMD prevalence has not been estimated for the US in over a decade and early-stage AMD prevalence estimates are scarce and inconsistently measured ...
David B. Rein, J. Wittenborn, Zeb Burke-Conte, Rohit Gulia, Toshana Robalik, Joshua R. Ehrlich, E. Lundeen, A. Flaxman   +7 more
semanticscholar   +1 more source

Macular Pigment Optical Density and its Determinants among Adults: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: Interplay exists between the risk factors of Agerelated Macular Degeneration (AMD) and the factors influencing Macular Pigment Optical Density (MPOD) level.
POOJA GOYAL, MITASHA SINGH, SHASHI VASHISHTH, SATISH JAYERIA   +3 more
doaj   +1 more source