Results 211 to 220 of about 205,027 (361)
A Comprehensive Survey of Sequence Variation in the ABCA4 (ABCR) Gene in Stargardt Disease and Age-Related Macular Degeneration
, 2000 Andrea Rivera, Karen L. White, Heidi Stöhr, Klaus Steiner, Nadine Hemmrich, T. Grimm, Bernhard Jurklies, Birgit Lorenz, Hendrik P. N. Scholl, E Apfelstedt-Sylla, Bernhard H. F. Weber +10 moreopenalex +1 more sourceLoss of 18q Alters TGFβ Signalling Affecting Anteroposterior Neuroectodermal Fate in Human Embryonic Stem Cells
Cell Proliferation, EarlyView.hESCsdel18q exhibit delayed and impaired anterior neuroectoderm induction, leading to deficient RPE specification. hESCsdel18q lines showed dysregulation of TGFβ signalling, and endogenous overactivation of activin/nodal/TGFβ in hESCsdel18q leads to improper anterior/posterior neuroectodermal fate commitments.Yingnan Lei, Mai Chi Duong, Nuša Krivec, Charlotte Janssens, Marius Regin, Anfien Huyghebaert, Edouard Couvreu de Deckersberg, Karen Sermon, Diana Al Delbany, Claudia Spits +9 morewiley +1 more sourceHAWK and HARRIER: Phase 3, Multicenter, Randomized, Double-Masked Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration.
Ophthalmology (Rochester, Minn.), 2019 P. Dugel, A. Koh, Y. Ogura, G. Jaffe, U. Schmidt-Erfurth, David M. Brown, A. Gomes, J. Warburton, A. Weichselberger, F. Holz +9 moresemanticscholar +1 more sourceTargeting ROCK1/YAP1 Axis Ameliorates Inflammation‐Induced Prostatic Hyperplasia via Stabilising SIRT1‐Dependent Mitochondrial Dynamics
Cell Proliferation, EarlyView.Prostate‐specific YAP1 overexpression induces pathological BPH phenogenesis. Targeting ROCK1/YAP1 with fasudil and verteporfin alleviates inflammatory BPH lesions. YAP1 orchestrates mitochondrial dysfunction and oxidative stress via suppressing SIRT1 function.Dongxu Lin, Pengyu Wei, Mengyang Zhang, Kang Li, Lina Li, Zhipeng Li, Changcheng Luo, Wenbo Kuang, Kai Cui, Zhong Chen +9 morewiley +1 more sourceMultiply scattered light tomography and confocal imaging: detecting neovascularization in age-related macular degeneration
, 2000 A. E. Elsner, Masahiro Miura, Stephen A. Burns, Eva Beausencourt, Christian Kunze, Linda M. Kelley, Joseph P. Walker, Glenn Wing, Paul Raskauskas, Donald C. Fletcher, Qinjie Zhou, Andreas W. Dreher +11 moreopenalex +1 more sourceAge-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy.
Genes and Diseases, 2021 Yanhui Deng, Lifeng Qiao, Mingyan Du, Chao Qu, Ling Wan, Jie Li, Lulin Huang +6 moresemanticscholar +1 more source