Results 231 to 240 of about 93,339 (287)

Humanin Mitigates Aβ‐Induced Retinal Pigment Epithelium Injury via AMPK‐Beclin1‐Dependent Mitophagy

Aging Cell, Volume 25, Issue 7, July 2026.
Humanin (HN) enhanced the clearance of Aβ‐accumulated mitochondria in the RPE while preserving retinal function and RPE barrier integrity. HN activated AMP‐activated protein kinase (AMPK), leading to phosphorylation of ULK1 and Beclin1, which promoted the interaction between Beclin1 and Parkin and their translocation to mitochondria.
Ha Young Jang, Suyeon Choi, Soo‐Jin Kim, Sooyun Kim, Dong Hyun Jo, Tae Geol Lee, Kyu‐Sang Park, Jeong Hun Kim   +7 more
wiley   +1 more source

Community Optometrist-Led Monitoring of Quiescent Neovascular Age-Related Macular Degeneration: The FENETRE Randomized Clinical Trial.

JAMA Netw Open
Sharma A, Jaber A, Pal B, Lawrenson JG, Harper RA, Tufail A, Learoyd AE, Robinson E, Douiri A, Burman R, Kernohan A, Vougioukalou S, Read S, Csontos J, Jones A, Mahmood S, McKibbin M, Peacock JL, Gale R, Patel PJ, Keane PA, Hamilton R, Vale L, Bunce C, Balaskas K.   +24 more
europepmc   +1 more source

Neovascular age-related macular degeneration without drusen. [PDF]

Acta Ophthalmol
Sirks MJ, van Dijk EHC, Ghalayini H, Bazdar S, Yu W, Yzer S, Martinez Ciriano JP, Schlingemann RO, Diederen RMH, Boon CJF.   +9 more
europepmc   +1 more source

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source

Functional and Structural Outcomes of Photobiomodulation Therapy in Dry Age-Related Macular Degeneration: A Single-Center Experience. [PDF]

J Clin Med
Ipek SC, Durmaz Engin C, Karatas E, Yildirim C, Grzybowski A.   +4 more
europepmc   +1 more source

Updates on Mediterranean diet and health status: active ingredients and pharmacological mechanisms

British Journal of Pharmacology, Volume 183, Issue 13, Page 3484-3502, July 2026.
The Mediterranean diet (MedDiet) is among the most extensively studied dietary patterns and has been consistently associated with reduced risk of all‐cause mortality, cardiovascular disease, metabolic disorders, cognitive decline and several types of cancers.
Lukas Schwingshackl, Jakub Morze, Sabina Wallerer, Georg Hoffmann   +3 more
wiley   +1 more source

PCSK9 Inhibitor Use and the Risk of Age-Related Macular Degeneration in Patients with Atherosclerotic Cardiovascular Disease. [PDF]

Pharmaceuticals (Basel)
Tsai HR, Hsu JZ, Loh CH, Huang HK.
europepmc   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, Volume 293, Issue 13, Page 4064-4084, July 2026.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

AMD-UPerNet: a tool for retinal layer and fluid assessment in age-related macular degeneration. [PDF]

BMC Med Imaging
Ma Q, Liu X, Li J, Bai Y, Mu W, Li N, Yan B, Wang Z.   +7 more
europepmc   +1 more source