Results 211 to 220 of about 93,339 (287)

First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT This guideline summarizes diagnostic and therapeutic approaches based on a systematic literature review and evidence evaluation using the GRADE methodology. Given the limited high‐quality data, expert consensus was additionally obtained through a modified Delphi process.
Giorgia Olivieri, Andrea Bordugo, Birute Burnyte, Alessandro Costetti, Maria‐Luz Couce, Luisa Diogo, Francois Feillet, D. Sean Froese, Benedetta Greco, Jean‐Louis Gueant, Luciana Hannibal, Friederike Hörster, Viktor Kožich, Giancarlo La Marca, Irini Manoli, Fanny Mochel, Lorenzo Orazi, Belén Pérez, Manuel Schiff, Bernd C. Schwahn, Ida Schwartz, Karolina M. Stepien, Jolanta Sykut‐Cegielska, Trine Tangeraas, Rolf H. Zetterström, Carlo Dionisi‐Vici, Martina Huemer   +26 more
wiley   +1 more source

Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers

MedComm, Volume 7, Issue 7, July 2026.
This schematic illustrates the hierarchical and interconnected nature of the primary molecular hallmarks of aging. The progression of aging is driven by a convergence of intrinsic molecular insults. Within the nucleus, genomic instability and telomere attrition trigger persistent DDR, accompanied by extensive epigenetic alterations.
Guowei Cai, Jia Ren, Li Wang, Yingying Wu, Huirui Wang, Xiaomeng Cao, Hao Shang, Xuben Hou, Yujiu Wang, Haibo Xue, Ting Dong   +10 more
wiley   +1 more source

Evaluation of risk promoting effects for age-related macular degeneration by estradiol. [PDF]

PLoS One
Pompös IM, Polenz D, Kociok N, Winkler S, Strauß O.   +4 more
europepmc   +1 more source

Generative Artificial Intelligence and Large Language Models in Clinical Oncology

MedComm, Volume 7, Issue 7, July 2026.
By integrating multimodal data, including medical imaging, pathology, omics, and electronic health records, generative AI and LLMs support cancer diagnosis, treatment planning, and follow‐up management. These technologies also enhance physician–patient communication, improve personalized treatment strategies, and leverage intelligent agent automation ...
Yunfang Yu, Zhenhui Zhao, Zehua Wang, Ruichong Lin, Yujie Tan, Yongjian Chen, Ting Li, Daniel Baptista‐Hon, Xiaoxi Zhang, Chuan Wu, Man Tong, Lijun Zheng, Junyan Wu, Olivia Monteiro, Kang Zhang   +14 more
wiley   +1 more source

Pharmacotherapy for Age-Related Macular Degeneration

Journal of Ophthalmic & Vision Research, 2008
Hamid Ahmadieh
doaj  

Gene Therapy Advancements in Age-Related Macular Degeneration Treatment. [PDF]

Cells
Amaxilati E, Chatzimichail E, Tsiropoulos GN, Motta L, Empeslidis T, Gatzioufas Z, Panos GD.   +6 more
europepmc   +1 more source

ABCA4‐Associated Retinal Degeneration in 8 Families From the Three Provinces of Northeast China: Identification and Characterization of Potentially Novel Variants

Molecular Genetics &Genomic Medicine, Volume 14, Issue 7, July 2026.
This study reports the documented case of ABCA4‐associated early‐onset severe retinal dystrophy in China, broadens the mutational spectrum of ABCA4 in this population, and highlights distinct genotype–phenotype correlations that may inform clinical management and genetic counseling.
Nian Li, Linlin Su, Yue Ren, Ye Liu, Jiayuan Ge, Henan Sun, Zhuoshi Wang   +6 more
wiley   +1 more source

Genetic determinants of age-related macular degeneration in Middle Eastern populations: a systematic review. [PDF]

Front Genet
Sannan NS.
europepmc   +1 more source

Gene Panel Analysis Reveals Overlapping Genetic Causes of Inherited Cataracts and Other Ocular Phenotypes in Bulgarian Patients

Molecular Genetics &Genomic Medicine, Volume 14, Issue 7, July 2026.
We have identified 4 pathogenic/likely pathogenic changes and 2 variants of uncertain significance, 3 of which were novel. The identification of disease‐causing variants in the CRYAA, MYH9, RP2, and CLNC1 genes allowed us to establish an accurate genetic diagnosis of inherited cataract and to describe overlapping clinical phenotypes.
Kristiyana Vitanova, Kunka Kamenarova, Nevyana Veleva‐Krasteva, Kalina Mihova, Yoanna Kaneva, Reni Tzveova, Martin Georgiev, Delyan Georgiev, Ivanka Dimova, Alexander Oscar, Radka Kaneva   +10 more
wiley   +1 more source

Microperimetry-Based Fixation Training in Patients with Age-Related Macular Degeneration (AMD). [PDF]

J Clin Med
Ciszewska K, Winiarczyk M, Winiarczyk D, Mackiewicz J.   +3 more
europepmc   +1 more source