Results 131 to 140 of about 629,919 (312)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Senescence diversity in muscle aging
Nature Aging, 2022 Matej Durik, William M. Keyes
openaire +2 more sources
Age Concern's response to the Government's consultation 'Equality and diversity: making it happen'
, 2003 SIGLEAvailable from British Library Document Supply Centre- DSC:m03/20788 / BLDSC - British Library Document Supply CentreGBUnited ...
Age Concern England (United Kingdom)
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Barriers to mature age employment: final report of the consultative forum on mature age participation [PDF]
, 2012 This report looks into barriers faced by mature age Australians in the workplace or looking for a job, and the development of recommendations to overcome these barriers.
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Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Age Diversity and Diversity Management in Europe
Abstract Europe is facing a multitude of challenges associated with the increasing average age of workers and the progressing digitalisation of work and private life. This chapter contributes to the aim of the book by highlighting the complex consequences of digitalisation for older workers, and providing an overview of the current ...
Petia Genkova, Henrik Schreiber
openaire +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Diversity in Students’ Study Practices in Higher Education [PDF]
A plethora of studies document the profound contextual changes leading amongst other things to diversity of the student population in the higher education sector in the developed world in the last two decades.
Adrian Ashman, Mohammad Alauddinh
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Inverse relationship between genetic diversity and epigenetic complexity
, 2008 Early studies of molecular evolution revealed a correlation between genetic distance and time of species divergence. This observation provoked the molecular clock hypothesis and in turn the ‘Neutral Theory’, which however remains an ...
Shi Huang
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source