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Dose-response relationship between sleep duration and mediation of phenotypic age acceleration: A cross-sectional study. [PDF]

Medicine (Baltimore)
Liu Y, Qiao K.
europepmc   +1 more source

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Associations Between Longitudinal Loneliness, DNA Methylation Age Acceleration, and Cognitive Functioning.

The journals of gerontology. Series B, Psychological sciences and social sciences, 2023
OBJECTIVES Loneliness may influence aging biomarkers related to cognitive functioning, for example, through accelerated DNA methylation (DNAm) aging.
Morgan E. Lynch, T. Arpawong, Christopher R. Beam   +2 more
semanticscholar   +1 more source

Epigenetics of Autism Spectrum Disorders: A Multi-level Analysis Combining Epi-signature, Age Acceleration, Epigenetic Drift and Rare Epivariations Using Public Datasets

Current Neuropharmacology, 2023
Background Epigenetics of Autism Spectrum Disorders (ASD) is still an understudied field. The majority of the studies on the topic used an approach based on mere classification of cases and controls. Objective The present study aimed at providing a multi-
Gentilini Davide, C. Rebecca, Possenti Irene, Calzari Luciano, Ranucci Francesco, Nola Marta, Olivola Miriam, Brondino Natascia, Politi Pierluigi   +8 more
semanticscholar   +1 more source

Map of epigenetic age acceleration: a worldwide analysis.

Ageing Research Reviews
We present a systematic analysis of epigenetic age acceleration based on by far the largest collection of publicly available DNA methylation data for healthy samples (93 datasets, 23K samples), focusing on the geographic (25 countries) and ethnic (31 ...
I. Yusipov, Alena I. Kalyakulina, Arseniy Trukhanov, Claudio Franceschi, M. Ivanchenko   +4 more
semanticscholar   +1 more source

Loneliness, epigenetic age acceleration, and chronic health conditions.

Psychology and Aging
Having associations with a range of adverse physical health outcomes including mortality, loneliness is increasingly recognized as a pressing public health concern, but the mechanisms studied to date do not yet explain all loneliness-related health risk.
Colin D. Freilich, K. Markon, Steve W. Cole, Robert F. Krueger   +3 more
semanticscholar   +1 more source

Epigenetic age acceleration is associated with occupational exposures, sex, and survival in amyotrophic lateral sclerosis

EBioMedicine
Summary Background Amyotrophic lateral sclerosis (ALS) is linked to ageing and genetic and environmental risk factors, yet underlying mechanisms are incompletely understood.
Yue Zhao, Xiayan Li, Kai Wang, Gayatri R Iyer, Stacey A. Sakowski, Lili Zhao, Samuel J. Teener, K. Bakulski, John F. Dou, Bryan J. Traynor, Alla Karnovsky, Stuart A Batterman, Eva L. Feldman, M. A. Sartor, Stephen A. Goutman   +14 more
semanticscholar   +1 more source

DNA methyltransferase 1 (DNMT1) promotes cyst growth and epigenetic age acceleration in autosomal dominant polycystic kidney disease.

Kidney International
Alteration of DNA methylation leads to diverse diseases, and the dynamic changes of DNA methylation (DNAm) on sets of CpG dinucleotides in mammalian genomes are termed "DNAm age" and "epigenetic clocks" that can predict chronological age.
J. Zhou, L. X. Li, Hongbing Zhang, Ewud Agborbesong, Peter C. Harris, James P. Calvet, Xiaogang Li   +6 more
semanticscholar   +1 more source