Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity [PDF]
GeroScience, 2023 Abstract Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of centenarians. The three centenarian clocks were developed based on n = 7039 blood and saliva samples from individuals older than ...
Steve Horvath
exaly +10 more sources
Epigenetic clocks and programmatic aging. [PDF]
Ageing Res Rev, 2023 The last decade has seen remarkable progress in the characterization of methylation clocks that track biological age in humans and many other mammalian species. While the biological processes of aging that underlie these clocks have remained unclear, several clues have pointed to a link to developmental mechanisms.
Gems D, Virk RS, de Magalhães JP.
europepmc +4 more sources
Is the concept of mammalian epigenetic clocks universal and applicable to invertebrates? [PDF]
Frontiers in GeneticsCertain aspects of animal ageing can be quantified using molecular clocks or machine learning algorithms that are trained on specific omics data, with epigenetic clocks based on DNA methylation (DNAm) garnering the most attention.
Ryszard Maleszka
doaj +2 more sources
Epigenetic clocks moderate the impact of marital status transitions on health in older adults. [PDF]
PLoS ONEChronological age is commonly used to study aging, but biological aging may more accurately reflect cumulative life experiences and psychosocial stressors.
Meng-Jung Lin
doaj +2 more sources
What’s counted counts: the implications of underrepresentation for the application of epigenetic clocks in diverse populations [PDF]
Clinical EpigeneticsDNA methylation (DNAm) has been touted as a potential unified marker of the contributions of both inherited and environmental factors on an individual’s health.
Samuel F. P. Gibbs +5 more
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Frontiers in Marine Science, 2023 The distribution of age classes is a key demographic parameter of populations and thus proper age estimation is crucial for fisheries management and for conservation biology.
Francesc Piferrer
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Designing Epigenetic Clocks for Wildlife Research. [PDF]
Mol Ecol ResourABSTRACT The applications of epigenetic clocks – statistical models that predict an individual's age based on DNA methylation patterns – are expanding in wildlife conservation and management. This growing interest highlights the need for field‐specific design best practices.
Newediuk L +5 more
europepmc +4 more sources
DNA methylation accelerated age as captured by epigenetic clocks influences breast cancer risk
Frontiers in Oncology, 2023 IntroductionBreast cancer continues to be the leading form of cancer among women in the United States. Additionally, disparities across the breast cancer continuum continue to increase for women of historically marginalized populations.
Celina I Valencia
exaly +3 more sources
An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes [PDF]
Nature CommunicationsEpigenetic Clocks have been trained to predict chronological age, healthspan and lifespan. Such clocks are often analysed in relation to disease outcomes – typically using small datasets and a limited number of clocks. Here, we present a large-scale (n =
Christos Mavrommatis +9 more
doaj +2 more sources
Independent Avian Epigenetic Clocks for Ageing and Development. [PDF]
Mol Ecol ResourAbstract Information on individual age is a fundamental aspect in many ecological and evolutionary studies. However, accurate and non-lethal methods that can be applied to estimate the age of wild animals are often absent.
Haller A, Risse J, Sepers B, van Oers K.
europepmc +4 more sources