Results 21 to 30 of about 193,396 (281)
Biology, 2023 Biological aging biomarkers, such as leukocyte telomere length (LTL) and epigenetic clocks, have been associated with the risk of cerebral small vessel disease (CSVD) in several observational studies.
Biying Lin, Yuzhu Mu, Zhongxiang Ding
doaj +1 more source
An evolutionary epigenetic clock in plants
Science, 2023 Molecular clocks are the basis for dating the divergence between lineages over macroevolutionary timescales (~10 5 to 10 8 years). However, classical DNA-based clocks tick too slowly to inform us about the recent past.
Yao, N. +12 more
openaire +6 more sources
Genome Biology, 2022 Background Epigenetic clocks use DNA methylation (DNAm) levels of specific sets of CpG dinucleotides to accurately predict individual chronological age.
Thomas H. Jonkman +11 more
doaj +1 more source
Circadian clocks, epigenetics, and cancer [PDF]
Current Opinion in Oncology, 2015 The interplay between circadian rhythm and cancer has been suggested for more than a decade based on the observations that shift work and cancer incidence are linked. Accumulating evidence implicates the circadian clock in cancer survival and proliferation pathways.
Masri, Selma +2 more
openaire +4 more sources
Epigenetic Clock: DNA Methylation in Aging [PDF]
Stem Cells International, 2020 Aging, which is accompanied by decreased organ function and increased disease incidence, limits human lifespan and has attracted investigators for thousands of years. In recent decades, with the rapid development of biology, scientists have shown that epigenetic modifications, especially DNA methylation, are key regulators involved in this process ...
Shuang Jiang, Yuchen Guo
openaire +3 more sources
Epigenetic clock as a correlate of anxiety
NeuroImage: Clinical, 2020 DNA methylation changes consistently throughout life and age-dependent alterations in DNA methylation can be used to estimate one's epigenetic age. Post-mortem studies revealed higher epigenetic age in brains of patients with major depressive disorder, as compared with controls. Since MDD is highly correlated with anxiety, we hypothesized that symptoms
Marečková, Klára +8 more
openaire +4 more sources
Epigenetic clock and methylation studies in cats [PDF]
GeroScience, 2021 Abstract Human DNA methylation profiles have been used successfully to develop highly accurate biomarkers of aging (“epigenetic clocks”). Although these human epigenetic clocks are not immediately applicable to all species of the animal kingdom, the principles underpinning them appear to be conserved even in ...
Ken Raj +8 more
openaire +4 more sources
Inverse relationship between genetic diversity and epigenetic complexity [PDF]
, 2008 Early studies of molecular evolution revealed a correlation between genetic distance and time of species divergence. This observation provoked the molecular clock hypothesis and in turn the ‘Neutral Theory’, which however remains an ...
Shi Huang
core +1 more source
Epigenetic Clocks and Their Prospective Application in the Complex Landscape of Aging and Alzheimer’s Disease [PDF]
GenesFrancesca Cavalcanti +2 more
exaly +2 more sources
Additional file 1 of Evaluation of pediatric epigenetic clocks across multiple tissues
, 2023 Additional file 1: Table S1. Description of 20 participating cohorts. Table S2: Epigenetic clocks information. Table S3: Sample size stratified by tissue types, array platforms and birth term status for each epigenetic clock.
Carlos A. Camargo (8782952) +27 more
core +1 more source