Results 31 to 40 of about 193,396 (281)

Novel feature selection methods for construction of accurate epigenetic clocks.

PLoS Computational Biology, 2022
Epigenetic clocks allow us to accurately predict the age and future health of individuals based on the methylation status of specific CpG sites in the genome and are a powerful tool to measure the effectiveness of longevity interventions.
Adam Li, Amber Mueller, Brad English, Anthony Arena, Daniel Vera, Alice E Kane, David A Sinclair   +6 more
doaj   +1 more source

NEOage clocks - epigenetic clocks to estimate post-menstrual and postnatal age in preterm infants.

, 2021
Epigenetic clocks based on DNA methylation (DNAm) can accurately predict chronological age and are thought to capture biological aging. A variety of epigenetic clocks have been developed for different tissue types and age ranges, but none have focused on
Carter, Brian S, Dansereau, Lynne M, Padbury, James F, Pastyrnak, Steven L, Smith, Lynne M, Graw, Stefan, McGowan, Elisabeth C, DellaGrotta, Sheri A, Helderman, Jennifer, Marsit, Carmen J, Camerota, Marie, Everson, Todd M, Neal, Charles R, O\u27Shea, Michael, Hofheimer, Julie A, Lester, Barry M   +15 more
core   +1 more source

The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study

Epigenetics, 2022
Epigenetic clocks have been widely used to predict disease risk in multiple tissues or cells. Their success as a measure of biological ageing has prompted research on the connection between epigenetic pathways of ageing and the socioeconomic gradient in ...
Lauren L. Schmitz, Wei Zhao, Scott M. Ratliff, Julia Goodwin, Jiacheng Miao, Qiongshi Lu, Xiuqing Guo, Kent D. Taylor, Jingzhong Ding, Yongmei Liu, Morgan Levine, Jennifer A. Smith   +11 more
doaj   +1 more source

Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock

Genome Biology, 2022
Background A variety of epigenetic clocks utilizing DNA methylation changes have been developed; these clocks are either tissue-independent or designed to predict chronological age based on blood or saliva samples.
James E. Barrett, Chiara Herzog, Yoo-Na Kim, Thomas E. Bartlett, Allison Jones, Iona Evans, David Cibula, Michal Zikan, Line Bjørge, Nadia Harbeck, Nicoletta Colombo, Sacha J. Howell, Angelique Flöter Rådestad, Kristina Gemzell-Danielsson, Martin Widschwendter   +14 more
doaj   +1 more source

Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons

Molecular Brain, 2021
Induced pluripotent stem cells (iPSCs) and their differentiated neurons (iPSC-neurons) are a widely used cellular model in the research of the central nervous system.
Leonard C. Steg, Gemma L. Shireby, Jennifer Imm, Jonathan P. Davies, Alice Franklin, Robert Flynn, Seema C. Namboori, Akshay Bhinge, Aaron R. Jeffries, Joe Burrage, Grant W. A. Neilson, Emma M. Walker, Leo W. Perfect, Jack Price, Grainne McAlonan, Deepak P. Srivastava, Nicholas J. Bray, Emma L. Cope, Kimberley M. Jones, Nicholas D. Allen, Ehsan Pishva, Emma L. Dempster, Katie Lunnon, Jonathan Mill, Eilis Hannon   +24 more
doaj   +1 more source

Circadian clock: linking epigenetics to aging [PDF]

Current Opinion in Genetics & Development, 2014
Circadian rhythms are generated by an intrinsic cellular mechanism that controls a large array of physiological and metabolic processes. There is erosion in the robustness of circadian rhythms during aging, and disruption of the clock by genetic ablation of specific genes is associated with aging-related features.
Orozco-Solis, Ricardo, Sassone-Corsi, Paolo   +1 more
openaire   +4 more sources

A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking [PDF]

, 2022
Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data, but this data can be surprisingly unreliable. Here we show that technical noise produces deviations up to 9 years between replicates for six prominent epigenetic ...
Vinkers, Christiaan H, Minteer, Christopher J, Levine, Morgan E, van der Horst, Marte Z., Wang, Meng, Moore, Ann Zenobia, van der Horst, Marte, Boks, Marco P., Rutten, Bart, Minteer, Christopher J., Sturm, Gabriel, Rutten, Bart P F, Vinkers, Christiaan H., Boks, Marco, Crimmins, Eileen M., Moore, Ann, Crimmins, Eileen M, Higgins-Chen, Albert, van der Horst, Marte Z, Thrush, Kyra L., Rutten, Bart P.F., Luykx, Jurjen, Thrush, Kyra, Thrush, Kyra L, Luykx, Jurjen J., Hu-Seliger, Tina T, Vinkers, Christiaan, Gutwinski, Stefan, Higgins-Chen, Albert T., Levine, Morgan E., Minteer, Christopher, Hägg, Sara, Hu-Seliger, Tina T., Ferrucci, Luigi, Okhuijsen-Pfeifer, Cynthia, Levine, Morgan, Bandinelli, Stefania, Kuo, Pei-Lun, Geuze, Elbert, Luykx, Jurjen J, Vermetten, Eric, Lin, Jue, Higgins-Chen, Albert T, Rutten, Bart P. F., Boks, Marco P, Wang, Yunzhang, Schreiter, Stefanie, Crimmins, Eileen, Picard, Martin, Hu-Seliger, Tina, Niimi, Peter   +50 more
core   +1 more source

Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization

Clinical Epigenetics, 2023
Background Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecular hallmarks such as epigenetic alterations and telomere attenuation reflect the biological process of aging. Epigenetic
Yosra Bejaoui, Fathima Humaira Amanullah, Mohamad Saad, Sara Taleb, Martina Bradic, Andre Megarbane, Ali Ait Hssain, Charbel Abi Khalil, Nady El Hajj   +8 more
doaj   +1 more source

An epigenetic clock controls aging [PDF]

Biogerontology, 2015
We are accustomed to treating aging as a set of things that go wrong with the body. But for more than twenty years, there has been accumulating evidence that much of the process takes place under genetic control. We have seen that signaling chemistry can make dramatic differences in life span, and that single molecules can significantly affect ...
openaire   +4 more sources

An epigenetic clock for human skeletal muscle [PDF]

Journal of Cachexia, Sarcopenia and Muscle, 2019
Abstract Background Ageing is associated with DNA methylation changes in all human tissues, and epigenetic markers can estimate chronological age based on DNA methylation patterns across tissues. However, the construction of the original pan-tissue epigenetic clock did not include skeletal muscle ...
Voisin, S, Harvey, NR, Haupt, LM, Griffiths, LR, Ashton, KJ, Coffey, VG, Doering, TM, Thompson, JM, Benedict, C, Cedernaes, J, Lindholm, ME, Craig, JM, Rowlands, DS, Sharples, AP, Horvath, S, Eynon, N   +15 more
openaire   +7 more sources