Results 1 to 10 of about 474,048 (356)

mTOR at the nexus of nutrition, growth, ageing and disease

Nature Reviews Molecular Cell Biology, 2020
Grace Y Liu, David M Sabatini
exaly   +2 more sources

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Nature Reviews Molecular Cell Biology, 2020
Raffaella Di Micco, Valery Krizhanovsky, Darren J Baker   +2 more
exaly   +2 more sources

mTOR: from growth signal integration to cancer, diabetes and ageing

Nature Reviews Molecular Cell Biology, 2010
Roberto Zoncu, Alejo Efeyan, David M Sabatini   +2 more
exaly   +2 more sources

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

Nature Reviews Cardiology, 2018
Luigi Ferrucci, Elisa Fabbri
exaly   +2 more sources

NAD+ metabolism and its roles in cellular processes during ageing

Nature Reviews Molecular Cell Biology, 2020
Anthony J Covarrubias, Rosalba Perrone, Alessia Grozio   +2 more
exaly   +2 more sources

Promoting Independence Through quality dementia Care at Home (PITCH): a research protocol for a stepped-wedge cluster-randomised controlled trial

Trials, 2021
Background Home care service providers are increasingly supporting clients living with dementia. Targeted and comprehensive dementia-specific training for home care staff is necessary to meet this need. This study evaluates a training programme delivered
Steven Savvas, Anita M. Y. Goh, Frances Batchelor, Colleen Doyle, Erica Wise, Esther Tan, Anita Panayiotou, Sue Malta, Margaret Winbolt, Phillip Clarke, Jason Burton, Lee-Fay Low, Samantha M. Loi, Anne Fairhall, Meg Polacsek, Jay Stiles, Fenny Muliadi, Nadia Chau, Samuel Scherer, David Ames, Tanara Vieira Sousa, Briony Dow   +21 more
doaj   +1 more source

A landscape assessment of the use of patient reported outcome measures in research, quality improvement and clinical care across a healthcare organisation

BMC Health Services Research, 2023
Background Patient reported outcome measures (PROMs) can be used by healthcare organisations to inform improvements in service delivery. However, routine collection of PROMs is difficult to achieve across an entire healthcare organisation.
David A. Snowdon, Velandai Srikanth, Richard Beare, Lucy Marsh, Emily Parker, Kim Naude, Nadine E. Andrew   +6 more
doaj   +1 more source

Establishing an ethics and governance framework for access to and linkage of electronic health data for research projects.

International Journal of Population Data Science, 2022
Objectives To develop an ethics and governance framework for the National Centre for Healthy Ageing (NCHA) data platform that supports: streamlined access to data for research; transfer of data into secure data environments; linkage with a range of ...
Emily Parker, Tanya Ravipati, Richard Beare, Velandai Srikanth, Nadine Andrew   +4 more
doaj   +1 more source

Aging is associated with increased chromatin accessibility and reduced polymerase pausing in liver

Molecular Systems Biology, 2022
Regulation of gene expression is linked to the organization of the genome. With age, chromatin alterations occur on all levels of genome organization, accompanied by changes in the gene expression profile.
Mihaela Bozukova, Chrysa Nikopoulou, Niklas Kleinenkuhnen, Dora Grbavac, Katrin Goetsch, Peter Tessarz   +5 more
doaj   +1 more source

Who is your community? Co-designing a community engagement strategy for an emerging data platform.

International Journal of Population Data Science, 2022
Objectives To co-design with older Australian consumers and stakeholders a strategy for engaging the wider community with an emerging data platform, involving linked routinely collected electronic health data for research.
Kim Naude, Emily Parker, Roisin McNaney, Michelle Daniel, Richard Beare, Velandai Srikanth, Nadine Andrew   +6 more
doaj   +1 more source