Results 1 to 10 of about 762,957 (215)

Promoting Independence Through quality dementia Care at Home (PITCH): a research protocol for a stepped-wedge cluster-randomised controlled trial

Trials, 2021
Background Home care service providers are increasingly supporting clients living with dementia. Targeted and comprehensive dementia-specific training for home care staff is necessary to meet this need. This study evaluates a training programme delivered
Steven Savvas, Anita M. Y. Goh, Frances Batchelor, Colleen Doyle, Erica Wise, Esther Tan, Anita Panayiotou, Sue Malta, Margaret Winbolt, Phillip Clarke, Jason Burton, Lee-Fay Low, Samantha M. Loi, Anne Fairhall, Meg Polacsek, Jay Stiles, Fenny Muliadi, Nadia Chau, Samuel Scherer, David Ames, Tanara Vieira Sousa, Briony Dow   +21 more
doaj   +1 more source

A landscape assessment of the use of patient reported outcome measures in research, quality improvement and clinical care across a healthcare organisation

BMC Health Services Research, 2023
Background Patient reported outcome measures (PROMs) can be used by healthcare organisations to inform improvements in service delivery. However, routine collection of PROMs is difficult to achieve across an entire healthcare organisation.
David A. Snowdon, Velandai Srikanth, Richard Beare, Lucy Marsh, Emily Parker, Kim Naude, Nadine E. Andrew   +6 more
doaj   +1 more source

Establishing an ethics and governance framework for access to and linkage of electronic health data for research projects.

International Journal of Population Data Science, 2022
Objectives To develop an ethics and governance framework for the National Centre for Healthy Ageing (NCHA) data platform that supports: streamlined access to data for research; transfer of data into secure data environments; linkage with a range of ...
Emily Parker, Tanya Ravipati, Richard Beare, Velandai Srikanth, Nadine Andrew   +4 more
doaj   +1 more source

Aging is associated with increased chromatin accessibility and reduced polymerase pausing in liver

Molecular Systems Biology, 2022
Regulation of gene expression is linked to the organization of the genome. With age, chromatin alterations occur on all levels of genome organization, accompanied by changes in the gene expression profile.
Mihaela Bozukova, Chrysa Nikopoulou, Niklas Kleinenkuhnen, Dora Grbavac, Katrin Goetsch, Peter Tessarz   +5 more
doaj   +1 more source

Who is your community? Co-designing a community engagement strategy for an emerging data platform.

International Journal of Population Data Science, 2022
Objectives To co-design with older Australian consumers and stakeholders a strategy for engaging the wider community with an emerging data platform, involving linked routinely collected electronic health data for research.
Kim Naude, Emily Parker, Roisin McNaney, Michelle Daniel, Richard Beare, Velandai Srikanth, Nadine Andrew   +6 more
doaj   +1 more source

MARK-AGE biomarkers of ageing [PDF]

Mechanisms of Ageing and Development, 2015
Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age.
Bürkle, Alexander, Moreno Villanueva, María, Bernhard, Jürgen, Blasco, María, Zondag, Gerben, Hoeijmakers, Jan H. J., Toussaint, Olivier, Grubeck Loebenstein, Beatrix, Mocchegiani, Eugenio, Collino, Sebastiano, Gonos, Efstathios S., Sikora, Ewa, Gradinaru, Daniela, Dollé, Martijn, Salmon, Michel, Kristensen, Peter, Griffiths, Helen R., Libert, Claude, Grune, Tilman, Breusing, Nicolle, Simm, Andreas, FRANCESCHI, CLAUDIO, CAPRI, MIRIAM, Talbot, Duncan, Caiafa, Paola, Friguet, Bertrand, Slagboom, P. Eline, Hervonen, Antti, Hurme, Mikko, Aspinall, Richard   +29 more
openaire   +8 more sources

Implementing care for healthy ageing

BMJ Global Health, 2022
The WHO concept of Healthy Ageing (ie, the process of developing and maintaining the functional ability that enables well-being in older age) has initiated a global discussion about the need for shifting paradigms to reorient health and social services ...
Anshu Banerjee, Yuka Sumi, Matteo Cesari, Andrew Briggs, Hyobum Jang, Ritu Sadana, Jotheeswaran Amuthavalli Thiyagarajan, Zee A Han, Monica Perracini   +8 more
doaj   +1 more source

Mapping the use of patient reported outcomes at a health organisation to inform integration into hospital data systems.

International Journal of Population Data Science, 2022
Objectives Incorporating patient reported outcomes into health data linkage research ensures that the patient’s perspective is considered. We aimed to understand the use of patient reported outcomes across an entire healthcare organisation, to inform ...
David Snowdon, Velandai Srikanth, Lucy Marsh, Richard Beare, Emily Parker, Nadine Andrew   +5 more
doaj   +1 more source

On the Precision of Full-spectrum Fitting of Stellar Populations. III. Identifying Age Spreads [PDF]

, 2021
In this third paper of a series on the precision of obtaining ages of stellar populations using the full spectrum fitting technique, we examine the precision of this technique in deriving possible age spreads within a star cluster. We test how well an internal age spread can be resolved as a function of cluster age, population mass fraction, and signal-
arxiv   +1 more source

Regulation of the one carbon folate cycle as a shared metabolic signature of longevity

Nature Communications, 2021
Metabolic pathways are closely intertwined with longevity. Here the authors perform metabolomic profiling of canonical longevity pathways and show that folate and methionine cycle intermediates are changed in common, and further, genetic manipulation of ...
Andrea Annibal, Rebecca George Tharyan, Maribel Fides Schonewolff, Hannah Tam, Christian Latza, Markus Max Karl Auler, Adam Antebi   +6 more
doaj   +1 more source