Results 131 to 140 of about 1,879,010 (294)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Global Music Lessons for ages 14-16
, 2007 Designed to tie in with Oxjam, these activities celebrate music from across the globe. Choose from numerous stand-alone lessons, offering opportunities for singing, performing, composing, improvising, listening, and appraising.
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Food Science of Animal ResourcesThis study analyzed the effects of the dietary intake of processed meat products (ham, sausage, and bacon) with fermented foods (kimchi, soybean paste and red pepper paste) on colorectal cancer (CRC) risk, hematological parameters, and gut microbiota of ...
Seung Yun Lee +7 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The Middle Ages in the Modern Game: Representing the Play Element of Historical Cultures
, 2017 The representation of the Middle Ages and associated themes in videogames continues to draw academic interest (e.g. Kline 2014). Generally analytical approaches to historical representation in videogames concentrate on the inclusion and negotiation of ...
Chapman, Adam,
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Age Integration or Age Conflict as Society Ages? [PDF]
The Gerontologist, 2000 openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Global Music Lessons for ages 5-7
, 2007 Designed to tie in with Oxjam, these activities celebrate music from across the globe. Choose from numerous stand-alone lessons, offering opportunities for singing, performing, composing, improvising, listening, and appraising.
core