Results 121 to 130 of about 29,689 (270)

Complex Mechanical Loading and Pro‐Inflammatory Cytokines in Intervertebral Disc Degeneration

JOR SPINE, Volume 9, Issue 1, March 2026.
This study investigated the combined effects of dynamic compression and torsion with major pro‐catabolic cytokine interleukin‐1 beta (IL‐1β) and its inhibitor: interleukin‐1 receptor antagonist (IL‐1Ra), on bovine IVD in an ex vivo organ culture system and further evaluated the mechanical effects using a subject‐personalized finite element model based ...
Katherine B. Crump, Estefano Muñoz‐Moya, Kim de Graaf, Paola Bermudez‐Lekerika, Nicole Schwendener, Wolf‐Dieter Zech, Christine L. Le Maitre, Jérôme Noailly, Benjamin Gantenbein   +8 more
wiley   +1 more source

NFATc2-rearranged sarcomas: clinicopathologic, molecular, and cytogenetic study of 7 cases with evidence of AGGRECAN as a novel diagnostic marker

Modern Pathology, 2020
R. Perret, Julien Escuriol, V. Vélasco, Laétitia Mayeur, I. Soubeyran, C. Delfour, S. Aubert, M. Polivka, M. Karanian, A. Meurgey, S. Le Guellec, N. Weingertner, S. Hoeller, J. Coindre, F. Larousserie, G. Pierron, F. Tirode, F. Le Loarer   +17 more
semanticscholar   +1 more source

Single‐nucleus RNA sequencing identifies a novel tenogenic heterologous differentiation in endometrial carcinosarcomas: implications for diagnosis and tumor classification

The Journal of Pathology, Volume 268, Issue 2, Page 227-242, February 2026.
Abstract Carcinosarcomas (CSs) are aggressive biphasic tumors characterized by epithelial and mesenchymal components, whose histogenesis and differentiation dynamics remain poorly understood. We present single‐nucleus RNA sequencing (snRNA‐seq) analysis of six CSs (five endometrial and one ovarian) and two normal endometrial samples, profiling over 96 ...
Silvia González‐Martínez, José Palacios, Irene Carretero‐Barrio, Val Fernández‐Lanza, Alfonso Cortés‐Salgado, Javier Román, Xavier Matias‐Guiu, Sonia Gatius, Javier Cortés, Belén Pérez‐Mies   +9 more
wiley   +1 more source

Aggrecan fragmentology – pattern of aggrecan fragments in different diseases [PDF]

Osteoarthritis and Cartilage, 2014
Struglics, A., Hansson, M., Lohmander, L. S.   +2 more
openaire   +2 more sources

The tandem–random transition of cellular patterning: proposed roles of N‐cadherin‐based orientational cell adhesions in the development, maintenance, and degeneration of the nucleus pulposus

Biological Reviews, Volume 101, Issue 1, Page 268-278, February 2026.
ABSTRACT Intervertebral disc degeneration (IDD) can contribute to lower back and neck pain. In IDD, the most affected component of the intervertebral disc is the nucleus pulposus (NP). Derived from the notochord, where cells are organized into a tandem configuration, young NP cells cluster in three‐dimensional (3D) networks embedded in a gelatinous ...
Xiangyun Wei, Nam Vo, Gwendolyn A. Sowa
wiley   +1 more source

Histochemical localisation of versican, aggrecan and hyaluronan in the developing condylar cartilage of the fetal rat mandible [PDF]

, 2001
Shunichi Shibata, Kenji Fukada, Shoichi Suzuki, Takuya Ogawa, Yasuo Yamashita   +4 more
openalex   +1 more source

Impact of Growth Hormone Treatment in Children From an Extended Family With ACAN ‐Related Short Stature

Clinical Genetics, Volume 109, Issue 2, Page 374-379, February 2026.
This study evaluated growth hormone (GH) therapy in children from an extended family with genetically confirmed ACAN‐related short stature. While GH treatment improved growth velocity, the response varied among individuals, and its long‐term impact on final adult height remains to be determined.
Einat Shalev‐Goldman, Ayman Asaly, Hadas Ityel, Ben Pode‐Shakked, Dalit Modan‐Moses, Yael Levy‐Shraga   +5 more
wiley   +1 more source

Desumoylation of aggrecan and collagen II facilitates degradation via aggrecanases in IL-1β-mediated osteoarthritis

Journal of Pain Research, 2019
Bing Zhu,1 Guanxing Cui,1 Qifu Zhang,2 Xiankui Cheng,3 Shusen Tang11Department of Joint Surgery, The Affiliated Hospital of Weifang Medical University, Weifang, Shandong, People’s Republic of China; 2Department of Cancer Radiotherapy, The ...
Zhu B, Cui G, Zhang Q, Cheng X, Tang S
doaj  

"Aggrecanase" activity is implicated in tumour necrosis factor alpha mediated cartilage aggrecan breakdown but is not detected by an in vitro assay. [PDF]

, 1997
David J. Buttle, A Fowles, Mirna Z. Ilic, Christopher J. Handley   +3 more
openalex   +1 more source

The non-aggregated aggrecan in the human intervertebral disc can arise by a non-proteolytic mechanism [PDF]

European Cells & Materials, 2014
Analysis of both the aggregated and non-aggregated fractions of aggrecan isolated from adult human intervertebral disc using immunoblotting with antibodies specific for the different domains constituting the aggrecan core protein or atomic force ...
PJ Roughley, Y Geng, JS Mort
doaj