Results 131 to 140 of about 27,782 (234)

β‐Catenin‐Deficient Intervertebral Disc Cells Reduce Chemotactic Transcription and Myeloid Cell Recruitment to Injured Discs of Mice

Aging Cell, Volume 25, Issue 10, October 2026.
(Left) In young discs, Wnt signaling‐replete nucleus pulposus cells secrete ECM components and, upon disc injury, cytokines to recruit myeloid cells. (Right) Whereas, β‐catenin‐deficient disc cells, modeling age‐related absence of Wnt signaling, exhibit reduced anabolic activity and, upon disc injury, secrete fewer pro‐inflammatory cytokines and ...
Tori M. Kroon, Jazz Munitz, Anna Ranzenigo, Martin Umali, William Wang, Jonathan J. Huang, Abraham J. P. Teunissen, Nilsson Holguin   +7 more
wiley   +1 more source

Aggrecan degradation in health and disease [PDF]

, 2004
The main aggrecan catabolite, found in samples of synovial fluid from patients with arthritis, and released from cartilage explant cultures exposed to IL-1, both have the amino-terminal amino acid sequence 374ARGSV ...
Rees, Alison Jane
core  

Cartilage Extracellular Matrix Homeostasis in Knee Osteoarthritis: Pathomechanisms and Therapeutic Targeting

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Knee osteoarthritis (KOA) is a degenerative joint disease primarily driven by the disruption of homeostasis in the chondrocyte extracellular matrix (CECM). This review systematically examines the central role of CECM homeostasis in KOA pathogenesis and summarizes recent advances in this field.
Chao Du, Jiwei Zhong, Jialin Yang, Yanbo Huang, Qi Liu, Dongdong Cao, Tianci Guo, Jida Wang, Aifeng Liu   +8 more
wiley   +1 more source

Antibodies to MMP-cleaved aggrecan.

, 2001
The matrix metalloproteinases (MMPs) have a pivotal role in both normal and pathological turnover of the extracellular matrix. Whereas MMP protein can easily be detected by immunolocalization or Western blot analysis, the determination of whether or not ...
Fosang, AJ, Last, K, Jackson, DC, Brown, L   +3 more
core   +1 more source

Enhancement of aggrecan induced by scAAV6 mediated knockdown of ADAMTS4.

, 2017
Viral dose of 5000 vg/c from recombinant scAAV6 vectors AAV6-Ctrl or AAV6-ADAMTS4 were used for transduction of 1 x 105 NP cells. On day 3 of post-transduction, treated and untreated NP cells were transferred to scaffold and harvested on day 8, 16, 24 ...
Claudius Thomé (488641), Sebastian Hartmann (3753316), Anja Tschugg (3753322), Demissew Shenegelegn Mern (3753319)   +3 more
core   +1 more source

Aggrecan Synthesis and Secretion [PDF]

Journal of Biological Chemistry, 1998
Jing Zheng, Wei Luo, Marvin L. Tanzer
openaire   +1 more source

Ultrastructure and nanomechanical properties of aggrecan from native cartilage and engineered tissue [PDF]

, 2010
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2010.This electronic version was submitted by the student author.
Lee, Hsu-Yi
core  

The Effect of Geranium Leaf Essential oil Pelargonium graveolens on the Expression of MMPs, IL-1β, NO, and PGE2 in Collagenase-induced Arthritis in Rabbits [PDF]

Armaghane Danesh Bimonthly Journal
Background & aim: Chronic diseases, including osteoarthritis, are often debilitating due to their progressive course and affect the quality of life of the elderly.
H Maghsoudi, F Jola, GH Bakhshi Khanegi
doaj  

Desumoylation of aggrecan and collagen II facilitates degradation via aggrecanases in IL-1β-mediated osteoarthritis

Journal of Pain Research, 2019
Bing Zhu,1 Guanxing Cui,1 Qifu Zhang,2 Xiankui Cheng,3 Shusen Tang11Department of Joint Surgery, The Affiliated Hospital of Weifang Medical University, Weifang, Shandong, People’s Republic of China; 2Department of Cancer Radiotherapy, The ...
Zhu B, Cui G, Zhang Q, Cheng X, Tang S
doaj  

Specificity, frequency, and phenotype of citrullinated-specific T cells vary with disease activity in rheumatoid arthritis. [PDF]

JCI Insight
Rims C, DeBerg HA, Posso SE, Muir VS, Uchtenhagen H, Hocking AM, Bukiri H, Carlin J, Ng B, Linsley PS, James EA, Buckner JH.   +11 more
europepmc   +1 more source