Results 111 to 120 of about 21,330 (209)

The Effect of Geranium Leaf Essential oil Pelargonium graveolens on the Expression of MMPs, IL-1β, NO, and PGE2 in Collagenase-induced Arthritis in Rabbits [PDF]

Armaghane Danesh Bimonthly Journal
Background & aim: Chronic diseases, including osteoarthritis, are often debilitating due to their progressive course and affect the quality of life of the elderly.
H Maghsoudi, F Jola, GH Bakhshi Khanegi
doaj  

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta‐Analysis of Public Transcriptional Profiling Data From the Hippocampus and Cortex

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Understanding the congruent effects of different types of antidepressant treatments on sensitive brain regions, such as the hippocampus and cortex, can highlight essential mechanisms of action. We used a systematic meta‐analysis of public transcriptional profiling datasets to identify genes and functional gene sets that are differentially expressed ...
Eva M. Geoghegan, Megan H. Hagenauer, Erin Hernandez, Sophia Espinoza, Elizabeth I. Flandreau, Phi T. Nguyen, Adrienne N. Santiago, Mubashshir Ra’eed Bhuiyan, Sophie Mensch, Stanley J. Watson Jr., Huda Akil, René Hen   +11 more
wiley   +1 more source

Retinoic Acid‐Related Orphan Nuclear Receptor Alpha Promotes Cartilage Degeneration in Osteoarthritis by Activating the Wnt/β‐Catenin Pathway

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
During the development of OA, elevated RORα in chondrocytes inhibits β‐catenin degradation in the cytoplasm by activating the Wnt/β‐catenin signaling pathway. When β‐catenin protein accumulates excessively in the cytoplasm, it is transferred to the nucleus and binds to the cytosolic TCF/LEF transcriptional complex, which activates downstream target ...
Ruijue Zhu, Tianwei He, Jiawei Di, Lang Mai, Depeng Wu, Mudan Huang, Yankui Liu, Zhongyu Liu, Liangming Zhang, Lei He   +9 more
wiley   +1 more source

Desumoylation of aggrecan and collagen II facilitates degradation via aggrecanases in IL-1β-mediated osteoarthritis

Journal of Pain Research, 2019
Bing Zhu,1 Guanxing Cui,1 Qifu Zhang,2 Xiankui Cheng,3 Shusen Tang11Department of Joint Surgery, The Affiliated Hospital of Weifang Medical University, Weifang, Shandong, People’s Republic of China; 2Department of Cancer Radiotherapy, The ...
Zhu B, Cui G, Zhang Q, Cheng X, Tang S
doaj  

Probing nanomechanics of aggrecan and the aggrecan-rich pericellular matrix of chondrocytes in cartilage

, 2005
The mechanical properties of articular cartilage are associated with the extracellular matrix network of type II collagen and the proteoglycan, aggrecan, which in combination provide the tensile, shear, and compressive stiffness of the tissue. While the collagen network mainly provides resistance to tensile and shear deformation, aggrecan enmeshed ...
openaire   +1 more source

Mechanisms of Mucoid Degeneration in the Cruciate Ligament: Role of Denatured Aggrecan Accumulation and Tissue Dysfunction. [PDF]

Orthop Res Rev
Inoue A.
europepmc   +1 more source

Comparative Analysis of Dual-miRNA Mediated Stimulation of Nucleus Pulposus and Bone Marrow Derived Stem Cells for Intervertebral Disc Repair. [PDF]

JOR Spine
Néill TN, Wilson N, McDonnell J, O'Brien FJ, Curtin CM, Dixon JE, Brama PAJ, Buckley CT.   +7 more
europepmc   +1 more source

The Effect of Curcumin Treatment on Healing in a Rat Distal Femoral Osteochondral Defect Model. [PDF]

Cartilage
Balcı EC, Alagöz E, Acar A, Uslu M, Biçer O, Öztürk A, Başer E, Yaprak Bayrak B.   +7 more
europepmc   +1 more source

Duhuo Jisheng Decoction ameliorates experimental intervertebral disc degeneration by modulating immune-inflammatory responses through regulation of macrophage polarization. [PDF]

Front Immunol
Mei Y, Wang L, Song C, Lv R, Xie X, Liu Z.   +5 more
europepmc   +1 more source