Results 91 to 100 of about 21,330 (209)

Aggrecan fragmentology – pattern of aggrecan fragments in different diseases [PDF]

Osteoarthritis and Cartilage, 2014
Struglics, A., Hansson, M., Lohmander, L. S.   +2 more
openaire   +2 more sources

Lost in Translation: Why Biologic Therapies for Intervertebral Disc Degeneration and Low Back Pain Have Not Reached the Clinic (Yet)

JOR SPINE, Volume 9, Issue 3, September 2026.
From preclinical promise to clinical translation in intervertebral disc degeneration (IDD). Robust preclinical evidence supports a range of biologic therapies, with consistent improvements in imaging, extracellular matrix composition, inflammation, and behavior.
Luca Ambrosio, Jordy Schol, Clara Ruiz‐Fernandez, Vincenzo Denaro, Gianluca Vadalà, Daisuke Sakai   +5 more
wiley   +1 more source

The Role of Meprins on the Brain Extracellular Matrix and Perineuronal Nets

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Meprin β overexpression is implicated in Alzheimer's Disease. Recent studies identified brevican as a meprin β substrate, and this study demonstrates that meprin α co‐expression enhances meprin β‐mediated brevican cleavage. Further, neurocan and RPTPζ were identified as novel meprin β substrates in an N‐terminomics analysis of meprin β transgenic mice,
Simon Kreiselmaier, Maximilian Keller, Leonardo Nardi, Constantin Mueller, Nele von Wiegen, Kira Bickenbach, Lea Gröbner, Mohammad Abukhalaf, Andreas Tholey, Margareta M. Mueller, Hagen Körschgen, Michael J. Schmeisser, Christoph Becker‐Pauly, Claus U. Pietrzik   +13 more
wiley   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, Volume 13, Issue 38, 9 July 2026.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, Volume 13, Issue 37, 3 July 2026.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

A Biomimetic Lubricant Captures Hyaluronic Acid In Situ to Regenerate Cartilage: From Bench to Bedside

Advanced Science, Volume 13, Issue 37, 3 July 2026.
(a) The outstanding lubricative properties of natural articular cartilage arise from a composite coating composed of HA, lubricin, and phospholipids at its surface. Notably, lubricin facilitates the enrichment of synovial HA onto cartilage surfaces, and HA complexes with phospholipids, a key component to maintain extremely low friction under high ...
Yongan Lin, Zijian Yan, Jiayi Chen, Xiaochao Wang, Ruibin Lin, Yunqi Fu, Zhaoying Lv, Bohui Wu, Xuewei Cao, Renjian Xie, Ming Dong, Chenxiao Zheng, Li Ren   +12 more
wiley   +1 more source

Self-Consistent Field Modeling of Bottle-Brush with Aggrecan-like Side Chain

Biomimetics
Bottle-brush polymers with aggrecan-like side chains represent a class of biomimetic macromolecules that replicate key structural and functional features of natural complexes of aggrecans with hyaluronic acid (HA) which are the major components of ...
Ivan V. Mikhailov, Ivan V. Lukiev, Ekaterina B. Zhulina, Oleg V. Borisov   +3 more
doaj   +1 more source

LncRNA Mirt2 Attenuates Osteoarthritis Progression by Promoting miR‐429/TBK1‐Mediated Autophagy

Immunity, Inflammation and Disease, Volume 14, Issue 7, July 2026.
LncRNA Mirt2 promoted chondrocyte proliferation and alleviated chondrocyte apoptosis, inflammation, and cartilage degeneration by activating miR‐429/TBK1‐mediated autophagy. Consequently, lncRNA Mirt2 has the potential to be used in the future clinical diagnosis and treatment of OA.
Jian‐xin Zhang, Zheng Li, Ping Yang, Kang Pu, Qi Zhou, Hao Yan, Hong‐bo Hu   +6 more
wiley   +1 more source

Transcriptional Regulation of the Aggrecan Gene [PDF]

, 2017
Aggrecan is a large- aggregating proteoglycan that is essential for the function of articular cartilage. A loss of aggrecan is one of the major event in osteoarthritis, a debilitating and degenerative joint disease. To understand how a gene is lost and what fails to prevent transcription in disease state, an understanding of the bases of transcription ...
openaire   +1 more source

Thrombospondin‐4 Regulates Lipopolysaccharide‐Induced Apoptosis and Inflammation in Nucleus Pulposus Cells via the Phosphatidylinositol 3‐Kinase/Protein Kinase B Pathway

Immunity, Inflammation and Disease, Volume 14, Issue 7, July 2026.
ABSTRACT Objective This study investigated the expression profile of Thrombospondin‐4 (THBS4) in intervertebral disc degeneration (IDD) and clarify its regulatory role in lipopolysaccharide (LPS)‐induced apoptosis and inflammation in nucleus pulposus cells (NPCs) via the phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (AKT) pathway.
Yang Shu, Chunhua Sun, Shi Chen
wiley   +1 more source