Results 91 to 100 of about 27,782 (234)

Review of articular cartilage repair techniques and their application in the horse

Equine Veterinary Journal, EarlyView.
Abstract Articular cartilage lesions represent a significant career‐limiting problem in athletic horses. A healthy articular cartilage surface is vital for optimal joint function, and defects can result in irreversible degenerative changes. Successful treatment of cartilage lesions remains a long‐standing challenge for orthopaedic surgeons, prompting ...
Charlotte K. Barton, Brad B. Nelson, Laurie R. Goodrich   +2 more
wiley   +1 more source

Interaction of Cartilage Oligomeric Matrix Protein/Thrombospondin 5 with Aggrecan,

, 2019
Cartilage oligomeric matrix protein/thrombospondin 5 (COMP/TSP5) is a major component of the extracellular matrix (ECM) of the musculoskeletal system. Its importance is underscored by its association with several growth disorders.
Tuan, Rocky S., Herndon, Mary E., Patel, Nichlesh, Chen, Faye Hui, Lawler, Jack, Hecht, Jacqueline T.   +5 more
core   +1 more source

Cant1 Affects Cartilage Proteoglycan Properties: Aggrecan and Decorin Characterization in a Mouse Model of Desbuquois Dysplasia Type 1

Biomolecules
Desbuquois dysplasia type 1 (DBQD1) is a recessive chondrodysplasia caused by mutations in the CANT1 gene, encoding for the Golgi Calcium-Activated Nucleotidase 1 (CANT1). The enzyme hydrolyzes UDP, the by-product of glycosyltransferase reactions, but it
Chiara Gramegna Tota, Alessandra Leone, Asifa Khan, Antonella Forlino, Antonio Rossi, Chiara Paganini   +5 more
doaj   +1 more source

CD8+ T‐cells, CD86+ macrophages and TNF‐α signalling pathways are correlated with fetlock osteoarthritis in racehorses

Equine Veterinary Journal, EarlyView.
Abstract Background There is emerging evidence for the role of the immune system in osteoarthritis (OA) pathophysiology; however, little is known about how immune cells and the synovial transcriptome are altered in naturally occurring equine OA. Objectives To evaluate synovial fluid (SF) and synovial membrane (SM) immune cell populations and the SM ...
E. J. Secor, E. N. Chow, M. Thomas, L. Johnson, A. Siefert, B. Wagner, J. B. Engiles, H. L. Reesink   +7 more
wiley   +1 more source

Soluble Nanomedicine Against Soluble Neurosensitizers to Effectively Relieve Osteoarthritis Pain and Joint Damage

Exploration, EarlyView.
Osteoarthritis pain arises not only from joint damage but also from inflammation, abnormal bone changes, and excessive nerve activation inside the joint. In this study, we developed an injectable nanomedicine, LAC, that responds to the acidic environment of osteoarthritic joints to locally release two approved drugs, reducing inflammation, limiting ...
Junyan Liu, Feixiang Ding, Jiayi Li, Min Liu, Lingyu Su, Zixi Wang, Congying Pi, Shilong Jiang, Zhaokui Zeng, Changjun Li, Chao Zeng, Guanghua Lei, Kelong Ai   +12 more
wiley   +1 more source

Link protein has greater affinity for versican than aggrecan

, 2004
The function of link protein in stabilizing the interaction between aggrecan and hyaluronan to form aggrecan aggregates, via the binding of link protein to the aggrecan G1 domain and hyaluronan, is well established.
Grothe, Suzanne, Mort, John S., Shi, Shuiliang, Zhang, Yiping, Poole, A. Robin, Roughley, Peter J., O'Connor-McCourt, Maureen D.   +6 more
core   +1 more source

A Recessive Skeletal Dysplasia, SEMD Aggrecan Type, Results from a Missense Mutation Affecting the C-Type Lectin Domain of Aggrecan [PDF]

, 2008
Analysis of a nuclear family with three affected offspring identified an autosomal-recessive form of spondyloepimetaphyseal dysplasia characterized by severe short stature and a unique constellation of radiographic findings.
Ralph S. Lachman, Stanley F. Nelson, Merriman, B., Nelson, Stanley F., Briggs, Michael D., Michael D. Briggs, Cohn, D.H., Briggs, M.D., David L. Rimoin, Cohn, Daniel H., Krakow, D., Rimoin, David L., Stuart W. Tompson, Tompson, S.W., Funari, Vincent A., Maryline Fresquet, Merriman, Barry, Lachman, Ralph S., Vincent A. Funari, Barry Merriman, Fresquet, M.; id_orcid, Tompson, Stuart W., Lachman, R.S., Nelson, S.F., Deborah Krakow, Rimoin, D.L., Daniel H. Cohn, Funari, V.A., Fresquet, Maryline, Krakow, Deborah   +29 more
core   +1 more source

IGF2BP3 Overexpression Accelerates Osteoarthritis Progression by Promoting Glycolysis via m6A‐Dependent Stabilization of ECM1 mRNA

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT N6‐methyladenosine (m6A) plays a critical role in osteoarthritis (OA) pathogenesis. This study investigates the role of the m6A reader insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3) in OA progression. OA models were established in vivo through destabilization of the medial meniscus (DMM) surgery in mice and in vitro by ...
Xing‐Shi Yuan, Hao‐Jie Zhang, Jia‐Xiang Ding, Zheng‐Liang Luo, Min Chen, Xiao‐Qi Zhang, Xi‐Fu Shang, Zhe Ni, Ke‐Rong Wu   +8 more
wiley   +1 more source

Lixisenatide attenuates advanced glycation end products (AGEs)-induced degradation of extracellular matrix in human primary chondrocytes

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Osteoarthritis (OA) poses a growing threat to the health of the global population. Accumulation of advanced glycation end-products (AGEs) has been shown to upregulate expression of degradative enzymes such as matrix metalloproteinases (MMPs) and a ...
Xin Li, Fangteng Jia, Zhengqing Zhu, Lanfeng Huang   +3 more
doaj   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source