Results 81 to 90 of about 36,790 (258)

Monte Carlo simulations reveal the straightening up of an end-grafted flexible chain with a rigid side chain

, 2007
We have studied the conformational properties of a flexible end-grafted chain (length $N$) with a rigid side chain (length $S$) by means of Monte Carlo simulations.
A. Halperin, Dieter W. Heermann, K. Binder, Marcel Hellmann, Matthias Weiss   +4 more
core   +1 more source

ADAMTS‐1 cleaves a cartilage proteoglycan, aggrecan [PDF]

FEBS Letters, 2000
A disintegrin‐like and metalloproteinase with thrombospondin type I motifs‐1 (ADAMTS‐1) is an extracellular matrix‐anchored metalloproteinase. In this study we have demonstrated that ADAMTS‐1 is able to cleave a major cartilage proteoglycan, aggrecan.
Kuno, Kouji, Okada, Yasunori, Kawashima, Hiroto, Nakamura, Hiroyuki, Miyasaka, Masayuki, Ohno, Hiroshi, Matsushima, Kouji   +6 more
openaire   +2 more sources

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

Genotype and phenotype in patients with ACAN gene variants: Three cases and literature review

Molecular Genetics & Genomic Medicine
Objective To characterize the phenotype spectrum, diagnosis, and response to growth‐promoting therapy in patients with ACAN variants causing familial short stature. Methods Three families with ACAN variants causing short stature were reported.
Wei Tang, Ke‐Mi Wu, Qiong Zhou, Yan‐Fei Tang, Jun‐Fen Fu, Guan‐Ping Dong, Chao‐Chun Zou   +6 more
doaj   +1 more source

Wogonin pretreatment of infrapatellar fat pad mesenchymal stem cell-derived exosomes advances articular cartilage repair in osteoarthritis

Bone & Joint Research
Aims: Osteoarthritis (OA) is a chronic joint disorder characterized by progressive cartilage degeneration, inflammation, and subchondral bone remodelling.
Wenzhao Li, Minzhi Mao, Cheng Tao, Kewei Zhu   +3 more
doaj   +1 more source

Metabolic response of human osteoarthritic cartilage to biochemically characterized collagen hydrolysates [PDF]

, 2017
The most frequent disease of the locomotor system is osteoarthritis (OA), which, as a chronic joint disease, might benefit more from nutrition than acute illnesses.
Gazova, Zuzana, Kordelle, Jens, Lochnit, Guenter, Schadow, Saskia, Siebert, Hans-Christian, Simons, Viktor S., Steinmeyer, Juergen   +6 more
core   +2 more sources

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Fibroblast Growth Factor-10 (FGF-10) Mobilizes Lung-resident Mesenchymal Stem Cells and Protects Against Acute Lung Injury. [PDF]

, 2016
FGF-10 can prevent or reduce lung specific inflammation due to traumatic or infectious lung injury. However, the exact mechanisms are poorly characterized.
Bai, Chunxue, Liu, Jie, Pan, Jue, Qu, Jieming, Rong, Linyi, Seeley, Eric J, Song, Yuanlin, Tang, Xinjun, Tong, Lin, Wang, Qin, Zhou, Jian, Zhu, Xiaodan   +11 more
core   +1 more source

Aggrecan modulation of growth plate morphogenesis

Developmental Biology, 2009
Chick and mouse embryos with heritable deficiencies of aggrecan exhibit severe dwarfism and premature death, demonstrating the essential involvement of aggrecan in development. The aggrecan-deficient nanomelic (nm) chick mutant E12 fully formed growth plate (GP) is devoid of matrix and exhibits markedly altered cytoarchitecture, proliferative capacity,
Domowicz, Miriam S., Cortes, Mauricio, Henry, Judith G., Schwartz, Nancy B.   +3 more
openaire   +2 more sources

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source