Results 71 to 80 of about 27,782 (234)

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

Advanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo, Seetharaman Parashuraman, Maria Luigia Maresca, Angela Francesca Dinoi, Alessia Calcagnì, Riccardo Rizzo   +5 more
wiley   +1 more source

ADAMTS-1 and Aggrecan are both in the nucleus.

, 2016
(A) Colocalization of ADAMTS-1 and aggrecan. ADAMTS-1 (red), Aggrecan (green) and Nuclei (blue). Aggrecan is found in nuclei and cytoplasm and is colocalized with ADAMTS-1 in cell nucleolus (white arrows) in MCF7 and MDA-MB-231. Scale bar: 5 μm.
Ruy G. Jaeger (618268), Suély V. Silva (3233223), Maíra A. Lima (3233220), Vanessa M Freitas (3233226), Nathalie Cella (2889740)   +4 more
core   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Human intervertebral disc aggrecan inhibits nerve growth in vitro

, 2002
Objective: To assess the effects of human intervertebral disc aggrecan on nerve growth and guidance, using in vitro techniques. Methods: Aggrecan extracted from human lumbar intervertebral discs was incorporated into tissue culture substrata for the
Sally Roberts, Johnson, William E. B., Roberts, Sally, Caterson, Bruce, Stephen M. Eisenstein, William E. B. Johnson, Bruce Caterson, Dianna L. Hynds, Diane M. Snow, Eisenstein, Stephen M., Hynds, Dianna L., Snow, Diane M.   +11 more
core   +1 more source

Increased expression of aggrecan and biglycan mRNA in Achilles tendinopathy [PDF]

, 2006
To determine the expression of mRNA encoding the proteoglycans aggrecan, versican, biglycan and decorin in mid-tendon samples of chronic painful Achilles tendinopathy and ruptured Achilles tendons, compared with normal tendons.
Costa, M. L., Movin, T., Riley, G. P., Hazleman, B. L., Robinson, A. H. N., Corps, A. N., Costa, ML, Corps, AN, Movin, T,, Robinson, AHN, Riley, GP, Hazleman, BL   +11 more
core   +1 more source

Intervertebral Disc Proteoglycans: Multifunctional Tissue Stabilizing and Instructional Cell Regulatory Proteins That Control Tissue Homeostasis

JOR Spine
The intervertebral disc (IVD) is a tough fibrocartilaginous viscoelastic cushion interposed between spinal vertebrae. It has a composite structure whose material properties are due to the interplay between fibrillar collagens which, provide high tensile ...
James Melrose
doaj   +1 more source

Aggrecan: A target molecule of autoimmune reactions

Pathology & Oncology Research, 1996
Aggrecan in cartilage forms aggregates with hyaluronan and link protein, embedded in a collagen network. It accounts for the compressive stiffness and resilience of the hyaline cartilage. Many forms of inflammatory arthritis were shown to be accompanied with aggrecan degradation and loss from the cartilage. The loss of this major component of cartilage
Edit I, Buzás, Katalin, Mikecz, Tibor T, Glant   +2 more
openaire   +2 more sources

A Dual‐Functional Nanoplatform Targeting the dsDNA–cGAS Axis to Mitigate Disc Degeneration and Aberrant Innervation

Advanced Science, EarlyView.
RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He, Tianyu Chen, Zezheng Liu, Xinlin Huang, Ruitangbin Jiang, Yihao Liu, Baojing Xu, Yuxiang Li, Kangning Zhao, Huibo Yan, Lei Zhou, Can Liu, Qingchu Li   +12 more
wiley   +1 more source

Synthesis of an aggrecan mimic for osteoarthritis specific cartilage treatment

, 2011
A preliminary event in osteoarthritic degradation of cartilage is the cleavage of aggrecan proteoglycan from the cartilage extracellular matrix (ECM). Aggrecan provides the dense negative charges which attract and retain water, providing cartilage with ...
Bernhard, Jonathan C
core   +1 more source

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source