Results 101 to 110 of about 27,782 (234)

Insensitivity to Salt of Assembly of a Rigid Biopolymer Aggrecan

, 2008
International audienceMany polyelectrolytes, ranging from sulfonated polystyrene to DNA, exhibit a strong sensitivity of their phase behavior to salt concentration, especially to higher valence salts, which often lead to phase separation.
Horkay, Ferenc, Geissler, Erik, Basser, Peter J., Hecht, Anne-Marie   +3 more
core   +1 more source

Evaluation Serum Levels of Aggrecan, Fibulin-1, Lubricin, and β-Defensin 3 in Females with Rheumatoid Arthritis [PDF]

Al-Anbar Medical Journal
Background: Rheumatoid Arthritis (RA) is a chronic, systemic autoimmune inflammatory disease primarily affecting the joints. Despite the availability of diagnostic tools, identifying novel biomarkers that reflect joint pathology remains crucial for the ...
Istabraq Shihab, Shakir Alaaraji, Samah Alkubaisi   +2 more
doaj   +1 more source

Recent Advances in Cryogel Applications for Musculoskeletal Regeneration

Medicinal Research Reviews, EarlyView.
ABSTRACT Hydrogels have been widely used in tissue engineering due to their high‐water content and biocompatibility, yet their densely cross‐linked microstructure inherently limits cell infiltration, mass transport, and mechanical support. Cryogels, formed through partial freezing and crosslinking under subzero conditions, provide unique 3D macroporous
Dohee Kim, Shinwon Kang, Hyejin Jo, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Comparison of the effects of triamcinolone acetonide or platelet-rich plasma on expression of extracellular matrix-related genes in equine healthy chondrocytes in vitro

Ciência Rural
: In healthy cartilage, chondrocytes maintain an expression of collagens and proteoglycans and are sensitive to growth factors and cytokines that either enhance or reduce type II collagen synthesis. In osteoarthritis, pro-inflammatory cytokines, such as
Heloisa Einloft Palma, Miguel Gallio, Gabriele Biavaschi da Silva, Camila Cantarelli, Kalyne Bertolin, Patrícia Wolkmer, Julien Wergutz, Luciana Maria Fontanari Krause, Alexandre Krause, Alfredo Quites Antoniazzi, Karin Erica Brass, Flavio Desessards De La Corte   +11 more
doaj   +1 more source

Progress in bone tissue engineering biomaterials: Development, challenges, and prospects

VIEW, EarlyView.
Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang, Junlei Chai, Quanwei Ding, Luping Liu, Kejie Zhang, Jie Lin, Jianhua Zhang, Youju Huang   +7 more
wiley   +1 more source

Role of chondroitin sulfate proteoglycans (CSPGs) in synaptic plasticity and neurotransmission in mammalian spinal cord. [PDF]

, 2009
Chronic unilateral hemisection (HX) of the adult rat spinal cord diminishes conduction through intact fibers in the ventrolateral funiculus (VLF) contralateral to HX.
Victor L. Arvanian, Guillermo Garcia-Alias, Arsen S. Hunanyan, Joel M. Levine, James W. Fawcett, Lorne M. Mendell   +5 more
core  

Soluble Epoxide Hydrolase Inhibition Regulates Septoclast Activity to Promote Long Bone Growth and Fracture Healing by Enhancing Endothelial‐to‐Mesenchymal Notch Signalling

Cell Proliferation, EarlyView.
The sEH inhibitor TPPU upregulates endothelial HIF‐1α, activating the NOTCH signalling pathway between endothelial cells and mesenchymal stem cells. This promotes the differentiation and formation of FABP5+ septoclasts, enhances their participation in endochondral ossification, and ultimately improves longitudinal bone growth and fracture healing ...
Weixian Chen, Liangliang Liu, Xumeng Wang, Juanjuan Li, Jingyi Zhang, Xiaoli Shi, Qing Sun, Xu Chang, Jing Zhang, Jie Zhao, Fu Wang   +10 more
wiley   +1 more source

Saxagliptin suppresses degradation of type II collagen and aggrecan in primary human chondrocytes: a therapeutic implication in osteoarthritis

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Osteoarthritis (OA) is a major public health concern for which a reliable non-invasive treatment option has yet to be developed. In the present study, we investigated the effects of saxagliptin, a novel dipeptidyl peptidase IV (DPP-4) inhibitor, on ...
Ning Hu, Xuan Gong, Shijie Yin, Qi Li, Hao Chen, Yuwan Li, Feilong Li, Leilei Qing, Jianye Yang, Sizheng Zhu, Jiawei Wang, Junchao Li   +11 more
doaj   +1 more source

Itgb1‐Mediated Stabilization of Vimentin Alleviates Excessive Mechanical Stress‐Induced Nucleus Pulposus Cell Pyroptosis and Intervertebral Disc Degeneration via PINK1‐Parkin‐Dependent Mitophagy

Cell Proliferation, EarlyView.
Excessive mechanical stress induces nucleus pulposus cell pyroptosis and intervertebral disc degeneration. Itgb1 inhibits MNAT1‐mediated ubiquitination and degradation of Vimentin. Vimentin alleviates excessive mechanical stress‐induced nucleus pulposus cell pyroptosis and intervertebral disc degeneration through PINK1‐Parkin‐dependent mitophagy ...
Xuening Liu, Fengguang Yang, Yanni Duan, Hefang Xiao, Zhenyu Cao, Zhaoheng Wang, Haijun Zhang, Xuewen Kang   +7 more
wiley   +1 more source

Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus

, 2012
OBJECTIVE: To investigate aggrecan degradation in juvenile idiopathic arthritis (JIA). METHODS: The pattern and abundance of aggrecan fragments in synovial fluid (SF) aspirates from JIA patients were analyzed and compared with aggrecan fragments in SF ...
Akikusa, J, Fosang, AJ, Last, K, Lohmander, LS, Struglics, A, Allen, R   +5 more
core   +1 more source