Results 121 to 130 of about 27,782 (234)

4‐Methylumbelliferone Restores Age‐Related Changes in Perineuronal Nets, Memory, and Neuroinflammation

Glia, Volume 74, Issue 12, December 2026.
Brain aging alters perineuronal nets and neuroinflammation. 4‐methylumbelliferone reversed these aging‐associated changes. 4‐methylumbelliferone reduced age‐associated cognitive decline. Six months of chronic oral treatment was well tolerated. ABSTRACT Aging‐associated cognitive decline is closely linked to dysregulated glial activity and chronic ...
Anda Cimpean, Jana Mizerakova, Noelia Martinez‐Varea, Dana Marekova, Lucia Machova Urdzikova, James W. Fawcett, Pavla Jendelova, Jessica C. F. Kwok   +7 more
wiley   +1 more source

Aggrecan directs extracellular matrix mediated neuronal plasticity

, 2018
In the adult brain, the extracellular matrix (ECM) influences recovery after injury,susceptibility to mental disorders, and is in general a strong regulator of neuronal plasticity.
lensjo, Kristian K., Hafting, Torkel, Rowlands, Daire, Fawcett, J.W., Dick, Gunnar, yang, sujeong, Andrews, Melissa, Fyhn, Marianne, Dinh, Tovy   +8 more
core   +1 more source

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, Volume 58, Issue 6, Page 1552-1569, November 2026.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

The chondroitin sulphate epitope 846 of aggrecan : its relationship to aggrecan synthesis and its partial characterization

, 1997
The chondroitin sulphate epitope 846 of aggrecan is abundant in foetal cartilage, barely detectable in normal adult cartilage, but reappears in the cartilage and body fluids of arthritic patients. This epitope has been proposed to be a marker of aggrecan
Jugessur, Hiteshini Dhar.
core  

Self-Consistent Field Modeling of Bottle-Brush with Aggrecan-like Side Chain

Biomimetics
Bottle-brush polymers with aggrecan-like side chains represent a class of biomimetic macromolecules that replicate key structural and functional features of natural complexes of aggrecans with hyaluronic acid (HA) which are the major components of ...
Ivan V. Mikhailov, Ivan V. Lukiev, Ekaterina B. Zhulina, Oleg V. Borisov   +3 more
doaj   +1 more source

Histopathologic Analysis of the Morpho‐Functional Zones of the Human Acetabular Labrum

Clinical Anatomy, Volume 39, Issue 7, Page 787-800, October 2026.
ABSTRACT The structural and functional adaptation of soft tissues to mechanical load controls their ability to withstand injury and influences their capacity for healing. Similar to the knee meniscus, the acetabular labrum exhibits zonal differences in mechanical load distribution, resulting in distinct regions with unique structural and functional ...
Abdulaziz A. Alomiery, Andrew C. Hall, Thomas H. Gillingwater, Afaf Alsolami, Abduelmenem Alashkham   +4 more
wiley   +1 more source

Matrix metalloproteinase digestion of aggrecan in human cartilage tumours

, 1998
Substantial experimental and clinical evidence suggests that the catabolism of extracellular matrix components is a prerequisite for invasive and metastatic behaviour of solid tumours.
M Toriyama, H.J Mankin, Rosenberg, A.E, T Fondren, B.V Treadwell, Mankin, H.J, Toriyama, M, C.A Towle, Treadwell, B.V, Towle, C.A, A.E Rosenberg, Fondren, T   +11 more
core   +1 more source

Stable Isotope Labeling to Track De Novo Fatty Acid Synthesis in Mouse Cartilage‐Enriched Joint Tissue In Vivo: A Practical Workflow

Journal of Orthopaedic Research, Volume 44, Issue 10, October 2026.
ABSTRACT Cartilage is traditionally viewed as a metabolically quiescent tissue that relies primarily on exogenous lipid uptake to meet its energetic and structural demands. However, increasing evidence suggests that chondrocytes exhibit metabolically active behaviors, particularly under aging and pathological conditions.
Shadi Moradi, Anupama Binoy, Shouan Zhu
wiley   +1 more source

Calpain is involved in C-terminal truncation of human aggrecan

, 2010
Mature aggrecan is generally C-terminally truncated at several sites in the CS (chondroitin sulfate) region. Aggrecanases and MMPs (matrix metalloproteinases) have been suggested to be responsible for this digestion. To identify whether calpain, a common
Lund University., Struglics, André,, Björklund, Maria,   +2 more
core   +1 more source

Small Proteoglycans, Big Impact: Decorin, Biglycan, and Asporin in Musculoskeletal Tissue Health and Disease

Proteoglycan Research, Volume 4, Issue 4, October 2026.
ABSTRACT The extracellular matrix (ECM) is a dynamic and information‐rich network that integrates structural support with biochemical and mechanical signaling. Among its key regulatory components are the Small Leucine‐Rich Proteoglycans (SLRPs), a family of matrix molecules that coordinate extracellular architecture with cell signaling.
Alessandra Leone, Zsuzsa Jenei‐Lanzl, Frank Zaucke   +2 more
wiley   +1 more source