Results 41 to 50 of about 29,689 (270)

Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress [PDF]

Cell Death and Disease, 2014
In Alzheimer’s disease (AD), different types of neurons and different brain areas show differential patterns of vulnerability towards neurofibrillary degeneration, which provides the basis for a highly predictive profile of disease progression throughout
Anne Suttkus, Susanne Rohn, Stefan Weigel, Pia Glöckner, Thomas Arendt, Markus Morawski   +5 more
openalex   +2 more sources

Testing if Micro-CT Is Capable of Quantitating the Extent of Proteoglycan-Aggrecan Induced Axial Spondyloarthritis in Mice

Frontiers in Immunology, 2021
ObjectiveInjections of proteoglycan aggrecan (PGA) have been reported to induce axial spondyloarthritis (ax-SpA) in BALB/c mice. It is considered to be a model for radiographic ax-SpA.
Qing Han, Qing Han, ZhaoHui Zheng, ZhaoHui Zheng, Qiang Liang, Qiang Liang, Kui Zhang, Kui Zhang, FengFan Yang, FengFan Yang, XiangHui Fu, XiangHui Fu, Xing Luo, Xing Luo, Jin Ding, Jin Ding, Ronghua Xie, Ronghua Xie, WenXiao Zhu, WenXiao Zhu, Ping Zhu, Ping Zhu   +21 more
doaj   +1 more source

Gel-like behavior in aggrecan assemblies [PDF]

The Journal of Chemical Physics, 2008
Aggrecan, a large biological polyelectrolyte molecule with a bottlebrush shape, forms complexes with hyaluronic acid (HA) that provide compressive resistance in cartilage. In solutions of aggrecan alone, the concentration dependence of the osmotic pressure Π is marked by self-assembly of the molecules into aggregates.
Horkay, Ferenc, Basser, Peter J., Hecht, Anne-Marie, Geissler, Erik   +3 more
openaire   +3 more sources

The Link between Aggrecan and Familial Osteochondritis Dissecans

Surgeries, 2021
Osteochondritis dissecans (OCD) is a chronic disease of the articular cartilage characterized by focal lesions of subchondral bone and overlaying cartilage. Through the growing number of reports describing the high prevalence of OCD in some families, the
Samantha Ozere, Sami Chergui, Megan E. Cooke, Thierry Pauyo, Derek H. Rosenzweig   +4 more
doaj   +1 more source

Citrullinated Aggrecan Epitopes as Targets of Autoreactive CD4+ T Cells in Patients With Rheumatoid Arthritis

Arthritis & Rheumatology, 2019
Recognition of citrullinated antigens such as vimentin, fibrinogen, and α‐enolase is associated with rheumatoid arthritis (RA). Emerging data suggest that the matrix protein aggrecan is also recognized as a citrullinated antigen.
C. Rims, H. Uchtenhagen, M. Kaplan, C. Carmona-Rivera, P. Carlucci, K. Mikecz, Adrienn Markovics, J. Carlin, J. Buckner, E. James   +9 more
semanticscholar   +1 more source

ADAMTS‐1 cleaves a cartilage proteoglycan, aggrecan [PDF]

FEBS Letters, 2000
A disintegrin‐like and metalloproteinase with thrombospondin type I motifs‐1 (ADAMTS‐1) is an extracellular matrix‐anchored metalloproteinase. In this study we have demonstrated that ADAMTS‐1 is able to cleave a major cartilage proteoglycan, aggrecan.
Kuno, Kouji, Okada, Yasunori, Kawashima, Hiroto, Nakamura, Hiroyuki, Miyasaka, Masayuki, Ohno, Hiroshi, Matsushima, Kouji   +6 more
openaire   +2 more sources

Aggrecan Hypomorphism Compromises Articular Cartilage Biomechanical Properties and Is Associated with Increased Incidence of Spontaneous Osteoarthritis

International Journal of Molecular Sciences, 2019
The gene encoding the proteoglycan aggrecan (Agc1) is abundantly expressed in cartilage during development and adulthood, and the loss or diminished deposition of the protein results in a wide range of skeletal malformations.
P. Alberton, Hans Christian Dugonitsch, B. Hartmann, Ping Li, Z. Farkas, M. Saller, H. Clausen‐Schaumann, A. Aszódi   +7 more
semanticscholar   +1 more source

Endothelial dysfunction induces atherosclerosis: increased aggrecan expression promotes apoptosis in vascular smooth muscle cells

BMB Reports, 2019
Endothelial dysfunction-induced lipid retention is an early feature of atherosclerotic lesion formation. Apoptosis of vascular smooth muscle cells (VSMCs) is one of the major modulating factors of atherogenesis, which accelerates atherosclerosis ...
Sang‐Min Kim, J. Huh, Eun-Young Kim, Min-Kyung Shin, Jieun Park, Seong Who Kim, Wooseong Lee, Bongkun Choi, Eun-Ju Chang   +8 more
semanticscholar   +1 more source

Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries

Circulation, 2018
Background: Extracellular matrix (ECM) remodeling contributes to in-stent restenosis and thrombosis. Despite its important clinical implications, little is known about ECM changes post–stent implantation.
G. Suna, W. Wojakowski, Marc Lynch, J. Barallobre-Barreiro, X. Yin, U. Mayr, F. Baig, Ruifang Lu, M. Fava, R. Hayward, C. Molenaar, S. White, T. Roleder, K. Milewski, P. Gąsior, P. Buszman, P. Buszman, M. Jahangiri, C. Shanahan, Jonathan Hill, M. Mayr   +20 more
semanticscholar   +1 more source

Aggrecan is required for chondrocyte differentiation in ATDC5 chondroprogenitor cells

PLoS ONE, 2019
Aggrecan is an integral component of the extracellular matrix in cartilaginous tissues, including the growth plate. Heterozygous defects in the aggrecan gene have been identified as a cause of autosomal dominant short stature, bone age acceleration, and ...
Juanita K. Hodax, J. B. Quintos, P. Gruppuso, Qian Chen, Salomi Desai, C. Jayasuriya   +5 more
semanticscholar   +1 more source