Results 51 to 60 of about 29,689 (270)

High follicle‐stimulating hormone levels accelerate cartilage damage of knee osteoarthritis in postmenopausal women through the PI3K/AKT/NF‐κB pathway

FEBS Open Bio, 2020
Osteoarthritis is the main cause of pain and disability in the elderly, with the most commonly affected joint being the knee. The prevalence of knee osteoarthritis (KOA) is significantly increased in postmenopausal women, although the mechanisms ...
Yaping Liu, Mengqi Zhang, Dehuan Kong, Yan Wang, Jian Li, Wenjuan Liu, Yilin Fu, Jin Xu   +7 more
doaj   +1 more source

Visfatin promotes intervertebral disc degeneration by inducing IL-6 expression through the ERK/JNK/p38 signalling pathways

Adipocyte, 2021
Visfatin reportedly induces the expression of proinflammatory cytokines. Severe grades of intervertebral disc disease (IVDD) exhibit higher expression of visfatin than mild ones.
Haitao Cui, Xianfa Du, Caijun Liu, Shunlun Chen, Haowen Cui, Hui Liu, Jianru Wang, Zhaomin Zheng   +7 more
doaj   +1 more source

An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2

bioRxiv, 2017
Pain is the predominant symptom of osteoarthritis, but the connection between joint damage and the genesis of pain is not well understood. Loss of articular cartilage is a hallmark of osteoarthritis, and it occurs through enzymatic degradation of ...
Rachel E. Miller, Richard J. Miller, S. Ishihara, P. Tran, S. Golub, K. Last, A. Fosang, A. Malfait   +7 more
semanticscholar   +1 more source

Desumoylation of aggrecan and collagen II facilitates degradation via aggrecanases in IL-1β-mediated osteoarthritis

Journal of Pain Research, 2019
Background: Aggrecan plays a crucial role in the ability of tissues to withstand compressive loads during the pathological progression of osteoarthritis (OA).
B. Zhu, Guanxing Cui, Qifu Zhang, Xian-kui Cheng, Shusen Tang   +4 more
semanticscholar   +1 more source

Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction

Advanced Functional Materials, EarlyView.
Despite over three decades of research, no tissue‐engineered solution for auricular reconstruction in microtia patients has reached clinical translation. The key challenge lies in generating functional elastic cartilage ex vivo. Here, we integrate synergistic cell‐biomaterial strategies to engineer auricular grafts with mechanical and histological ...
Philipp Fisch, Sandra Kessler, Simone Ponta, Anna Puiggalí‐Jou, Guoliang Lyu, Killian Flégeau, Anastasiya Martyts, Florian Roth, David Fercher, Filippo M. Rijli, Daniel Simmen, Eva Novoa Olivares, Thomas Linder, Marcy Zenobi‐Wong   +13 more
wiley   +1 more source

ACAN Gene VNTR Polymorphism and Intervertebral Disc Degeneration in a Turkish Population

Haseki Tıp Bülteni, 2020
Aim:Intervertebral disc degeneration (IVDD) is caused by several genetic and environmental factors. Aggrecan is the major component of intervertebral disk matrix proteoglycan with multiple functional domains.
Tuba Öz, İsmail Kaya, Ayşe Feyda Nursal, Hasan Emre Aydın, Osman Demir, Serbülent Yiğit   +5 more
doaj   +1 more source

Poly I:C Activated Microglia Disrupt Perineuronal Nets and Modulate Synaptic Balance in Primary Hippocampal Neurons in vitro

Frontiers in Synaptic Neuroscience, 2021
Perineuronal nets (PNNs) are specialized, reticular structures of the extracellular matrix (ECM) that can be found covering the soma and proximal dendrites of a neuronal subpopulation.
David Wegrzyn, Nadja Freund, Andreas Faissner, Georg Juckel   +3 more
doaj   +1 more source

A Heparin‐Functionalized Scaffold with HB‐EGF Immobilization for Tissue Engineering

Advanced Healthcare Materials, EarlyView.
In this study, a heparin‐functionalized scaffold is designed for bio‐mimicking growth factors reservoir function of extracellular matrix. Due to the presence of heparin‐binding domain, heparin‐binding epidermal growth factor‐like growth factor (HB‐EGF) is effectively and spatially captured by heparin‐functionalized scaffold.
Bowu Peng, Huajian Chen, Chengyu Lu, Tianjiao Zeng, Man Wang, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen   +8 more
wiley   +1 more source

Structural Variation of Chondroitin Sulfate Chains Contributes to the Molecular Heterogeneity of Perineuronal Nets

Frontiers in Integrative Neuroscience, 2018
Aggrecan, a chondroitin sulfate (CS) proteoglycan, forms lattice-like extracellular matrix structures called perineuronal nets (PNNs). Neocortical PNNs primarily ensheath parvalbumin-expressing inhibitory neurons (parvalbumin, PV cells) late in brain ...
Shinji Miyata, Satomi Nadanaka, Michihiro Igarashi, Hiroshi Kitagawa   +3 more
doaj   +1 more source

The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness

Scientific Reports, 2018
Stiffening of the aorta is an important independent risk factor for myocardial infarction and stroke. Yet its genetics is complex and little is known about its molecular drivers.
Yasmin, R. A. Maskari, C. McEniery, S. Cleary, Ye Li, K. Siew, N. Figg, A. Khir, J. Cockcroft, I. Wilkinson, K. O’Shaughnessy   +10 more
semanticscholar   +1 more source