Results 241 to 250 of about 211,860 (282)

Gene Expression Changes as Biomarkers of Immunosenescence in Bulgarian Individuals of Active Age. [PDF]

Biomedicines
Nikolova D, Todorova Y, Hammoudeh Z, Rukova B, Emilova R, Aleksova M, Koleva V, Nikolova M.   +7 more
europepmc   +1 more source

Comparative analysis of two newly established Cre rat lines, NeuN‐Cre and Thy1‐Cre, for neurological research

Animal Models and Experimental Medicine, EarlyView.
We generated two neuron‐specific Cre rat lines, Thy1‐Cre and NeuN‐Cre, using CRISPR/Cas9‐mediated targeted insertion. Both lines were validated for high neural specificity by crossing them with a Cre reporter rat. When bred with an ND1 conditional knockout rat, the two Cre lines produced distinct phenotypic outcomes. These rat lines have been deposited
Keru Li, Chenyang Liu, Gefan Wan, Lei Zhang, Rui Fan, Xu Zhang, Yuanlong Su, Jiayue He, Ning Liu, Feifei Guan, Wei Dong, Shan Gao, Weining Kong, Xiaolong Qi, Xiaolin Zhang, Yuanwu Ma   +15 more
wiley   +1 more source

Dental fluorosis in the European roe deer (Capreolus capreolus): A review of the pathological changes in the enamel of fluorotic cheek teeth and the abnormal pattern of dental wear in affected dentitions

The Anatomical Record, EarlyView.
Abstract This article reviews the pathological changes in the enamel of permanent mandibular cheek teeth and their sequelae in European roe deer from regions polluted by anthropogenic fluoride emissions. The primary (developmental) changes of fluorotic roe deer enamel are hypomineralization and microstructural aberrations, including enamel hypoplasia ...
Uwe Kierdorf, Horst Kierdorf
wiley   +1 more source

Long‐Term Safety and Efficacy of Mepolizumab in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Objective Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, relapsing, inflammatory disease. Management of EGPA predominantly relies on oral corticosteroids (OCS), which are associated with many adverse effects. The phase 3 MIRRA trial demonstrated efficacy and safety of mepolizumab, anti‐interleukin‐5 biologic, for EGPA.
Michael E. Wechsler, Jared Silver, Gerhard Wolff, Robert G. Price, Rejina Verghis, Peter F. Weller, Peter A. Merkel, Paneez Khoury, on behalf of the EGPA Mepolizumab Open‐Label Extension study group, Arnaud Bourdin, Pascal Chanez, Anoop Chauhan, Vincent Cottin, Gerald Gleich, Berhnard Hellmich, Tomonori Ishii, David Jayne, Jean‐Emmanuel Kahn, Peter Kern, Nader Khalidi, Ina Koetter, Carol Langford, Amy Markezich, Paul Monach, Shamsa Naveed, Peter Oelzner, Kenneth Pinna, Xavier Puechal, Emory H. Robinette, Florence Roufosse, Reinhard Voll, Andrew Schafer, Kaharu Sumino, Masami Taniguchi, Phillip Lieberman   +34 more
wiley   +1 more source

Returning aging cells to productivity. [PDF]

Elife
Vaidya RW, Tang SY.
europepmc   +1 more source

Efficacy and safety of dotinurad versus febuxostat for the treatment of gout: a randomised, multicentre, double‐blind, phase 3 trial in China

Arthritis &Rheumatology, Accepted Article.
Objectives Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicentre, randomised, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad
Jia Sun, Yu Wang, Yongjing Cheng, Dongmei Guo, Jiankang Hu, Dongzhou Liu, Zhengnan Gao, Changgui Li, Yibing Lu, Xiaodan Kong, Yu Liu, Zhenyu Jiang, Bin Yi, Hongfeng Zhang, Baijie Xu, Shihao Yu, Rieko Kokan, Kohei Ishikawa, Mikiko Kawakatsu, Zhuoli Zhang   +19 more
wiley   +1 more source

New Insights into the Role of Cellular Senescence and Its Therapeutic Implications in Ocular Diseases. [PDF]

Bioengineering (Basel)
Wu J, Liu X, Liu Y, Su W, Zhuo Y.
europepmc   +1 more source

Clinical impact of multiparametric contrast‐enhanced dual‐energy computed tomography in arthritis imaging – a prospective single‐center study

Arthritis &Rheumatology, Accepted Article.
Objectives To evaluate the influence of contrast‐enhanced dual‐energy CT (CE‐DECT) in detecting and differentiating rheumatic joint diseases of the hand. Methods In this prospective study, patients with suspected arthritis of the hand were investigated consecutively alongside the standard clinical procedure.
Sevtap Tugce Ulas, Jürgen Mews, Sarah Ohrndorf, Robert Biesen, Katharina Ziegeler, Edgar Wiebe, Fabian Proft, Udo Schneider, Denis Poddubnyy, Torsten Diekhoff   +9 more
wiley   +1 more source

Counteracting Skin Aging In Vitro by Phytochemicals. [PDF]

J Cell Mol Med
Cruciani S, Garroni G, Serra D, Kavak FF, Satta R, Martini F, Tognon M, Ventura C, Maioli M.   +8 more
europepmc   +1 more source

Is Senolytic Therapy in Cardiovascular Diseases Ready for Translation to Clinics? [PDF]

Biomolecules
Yang Z, Potenza DM, Ming XF.
europepmc   +1 more source