Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning [PDF]
The EMBO Journal 27, 9 (2008) 1321-1332, 2008 The G-protein-coupled receptor (GPCR) activated by the neurotransmitter GABA is made up of two subunits, GABA(B1) and GABA(B2). GABA(B1) binds agonists, whereas GABA(B2) is required for trafficking GABA(B1) to the cell surface, increasing agonist affinity to GABA(B1), and activating associated G proteins.
arxiv +1 more source
Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit [PDF]
The Journal of Biological Chemistry 279, 16 (2004) 15824-30, 2008 The gamma-aminobutyric acid type B (GABAB) receptor is an allosteric complex made of two subunits, GABAB1 (GB1) and GABAB2 (GB2). Both subunits are composed of an extracellular Venus flytrap domain (VFT) and a heptahelical domain (HD). GB1 binds GABA, and GB2 plays a major role in G-protein activation as well as in the high agonist affinity state of ...
arxiv +1 more source
Communication over the network of binary switches regulates the activation of A$_{2A}$ adenosine receptor [PDF]
PLoS Comp. Biol. (2015) 11(2): e1004044, 2014 Dynamics and functions of G-protein coupled receptors (GPCRs) are accurately regulated by the type of ligands that bind to the orthosteric or allosteric binding sites. To glean the structural and dynamical origin of ligand-dependent modulation of GPCR activity, we performed total $\sim$ 5 $\mu$sec molecular dynamics simulations of A$_{2A}$ adenosine ...
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Neuroreceptor Activation by Vibration-Assisted Tunneling [PDF]
Scientific Reports 5, Article number: 9990 Published 2015, 2015 G protein-coupled receptors (GPCRs) constitute a large family of receptor proteins that sense molecular signals on the exterior of a cell and activate signal transduction pathways within the cell. Modeling how an agonist activates such a receptor is fundamental for an understanding of a wide variety of physiological processes and it is of tremendous ...
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A normative theory of social conflict [PDF]
arXiv, 2023 Social hierarchy in animal groups carries a crucial adaptive function by reducing conflict and injury while protecting valuable group resources. Social hierarchy is dynamic and can be altered by social conflict, agonistic interactions, and aggression.
arxiv
Ligand-dependent opening of the multiple AMPA receptor conductance states: a concerted model [PDF]
, 2014 Modulation of the properties of AMPA receptors at the post-synaptic membrane is one of the main suggested mechanisms behind synaptic plasticity in the central nervous system of vertebrates. Electrophysiological recordings of single channels stimulated with agonists showed that both recombinant and native AMPA receptors visit multiple conductance states
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Design Paradigms Based on Spring Agonists for Underactuated Robot Hands: Concepts and Application [PDF]
arXiv, 2020 In this paper, we focus on a rarely used paradigm in the design of underactuated robot hands: the use of springs as agonists and tendons as antagonists. We formalize this approach in a design matrix also considering its interplay with the underactuation method used (one tendon for multiple joints vs. multiple tendons on one motor shaft).
arxiv
Intuitive control of myoelectric prostheses with agonist-antagonist interface and magnetomicrometery: narrative review [PDF]
arXiv, 2023 Proprioception is crucial in intuitive control of prosthetic limbs and therefor contributes to intuitive prosthetic use. The agonist-antagonist myoneural interface (AMI) is an prosthetic innovation with enhanced control, reduced pain, and heightened proprioceptive sensation in clinical experiments.
arxiv
Inherent rhythm of smooth muscle cells in rat mesenteric arterioles: an eigensystem formulation [PDF]
Phys. Rev. E 93, 042415 (2016), 2016 On the basis of experimental data and mathematical equations in the literature, we remodel the ionic dynamics of smooth muscle cells (SMCs) as an eigensystem formulation, which is valid for investigating finite variations of variables from the equilibrium like in common experimental operations.
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Molecular dynamics simulations reveal the role of ceramicine B as novel PPARĪ³ partial agonist against type 2 diabetes [PDF]
arXiv, 2018 Peroxisome proliferator-activated receptors gamma (PPAR{\gamma}) are ligand-activated controllers of various metabolic actions and insulin sensitivity. PPAR{\gamma} is thus considered as an important target to treat type 2 diabetes. Available PPAR{\gamma} drugs (full agonists) have robust insulin-sensitizing properties but are accompanied by severe ...
arxiv