Results 1 to 10 of about 1,182,206 (391)
Frontiers in Pharmacology, 2023 Certain 4-substituted analogs of 1-(2,5-dimethoxyphenyl)isopropylamine (2,5-DMA) are psychoactive classical hallucinogens or serotonergic psychedelic agents that function as human 5-HT2A (h5-HT2A) serotonin receptor agonists.
Prithvi Hemanth +5 more
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TLRs as a Promise Target Along With Immune Checkpoint Against Gastric Cancer
Frontiers in Cell and Developmental Biology, 2021 Gastric cancer (GC) is one of the most common cancers in the world, and the incidence of gastric cancer in Asia appears to increase in recent years. Although there is a lot of improvement in treatment approaches, the prognosis of GC is poor.
Lin Cui, Xiuqing Wang, Dekai Zhang
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Memory Studies, 2016 Building on Mouffe’s critique of cosmopolitanism, this article argues that a cosmopolitan mode of remembering, far from having superseded the antagonistic mode associated with ‘first modernity’ in the European context, has proved unable to prevent the rise of, and is being increasingly challenged by, new antagonistic collective memories constructed by
Cento Bull, Anna, Hansen, Hans Lauge
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Doubles-agonistes, tri-agonistes et multi-agonistes incrétines/glucagon
Médecine des Maladies Métaboliques, 2021 Resume L’innovation pharmacologique en diabetologie est un veritable defi. La nouvelle famille des co-agonistes des recepteurs GIP/GLP-1 represente une avancee therapeutique importante pour ameliorer la prise en charge du diabete de type 2 (DT2). L’activation des deux recepteurs incretines peut avoir des effets metaboliques additifs en comparaison a ...
Phan, Franck, Andreelli, Fabrizio
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Predicting GPR40 Agonists with A Deep Learning‐Based Ensemble Model
ChemistryOpen, 2023 Recent studies have identified G protein‐coupled receptor 40 (GPR40) as a promising target for treating type 2 diabetes mellitus, and GPR40 agonists have several superior effects over other hypoglycemic drugs, including cardiovascular protection and ...
Jiamin Yang +4 more
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The relationship between anti-mullerian hormone and ovarian response and fertility outcome in infertile women undergoing assisted reproductive techniques (ART) and IUI [PDF]
Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2023 Introduction: Anti-Mullerian Hormone (AMH) is related to woman's age, the number of antral follicles, and the outcome of assisted reproductive techniques.
Fariba Seyedoshohadaei +3 more
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eLife, 2021 Ligand binding stabilizes different G protein-coupled receptor states via a complex allosteric process that is not completely understood. Here, we have derived free energy landscapes describing activation of the β2 adrenergic receptor bound to ligands ...
Oliver Fleetwood +2 more
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Receptor modulators associated with the hypothalamus -pituitary-thyroid axis
Frontiers in Pharmacology, 2023 The hypothalamus-pituitary-thyroid (HPT) axis maintains normal metabolic balance and homeostasis in the human body through positive and negative feedback regulation.
Xianbin Cheng +7 more
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Characterization of TR‐107, a novel chemical activator of the human mitochondrial protease ClpP
Pharmacology Research & Perspectives, 2022 We recently described the identification of a new class of small‐molecule activators of the mitochondrial protease ClpP. These compounds synthesized by Madera Therapeutics showed increased potency of cancer growth inhibition over the related compound ...
Emily M. J. Fennell +16 more
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Functional Stoichiometry at the Nicotinic Receptor. The Photon Cross Section for Phase 1 Corresponds to Two Bis-Q Molecules per Channel [PDF]
, 1982 These experiments examine changes in the agonist-induced conductance that occur when the agonist-receptor complex is perturbed. Voltage-clamped Electrophorus electroplaques are exposed to the photoisomerizable agonist trans-Bis-Q A 1-µs laser flash ...
Lester, Henry A., Sheridan, Robert E.
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