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The relationship between anti-mullerian hormone and ovarian response and fertility outcome in infertile women undergoing assisted reproductive techniques (ART) and IUI [PDF]

Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2023
Introduction: Anti-Mullerian Hormone (AMH) is related to woman's age, the number of antral follicles, and the outcome of assisted reproductive techniques.
Fariba Seyedoshohadaei, Masomeh Rezaie, Khaled Rhmani, Fariba Bakhshi   +3 more
doaj   +1 more source

TLRs as a Promise Target Along With Immune Checkpoint Against Gastric Cancer

Frontiers in Cell and Developmental Biology, 2021
Gastric cancer (GC) is one of the most common cancers in the world, and the incidence of gastric cancer in Asia appears to increase in recent years. Although there is a lot of improvement in treatment approaches, the prognosis of GC is poor.
Lin Cui, Xiuqing Wang, Dekai Zhang
doaj   +1 more source

Identification of ligand-specific G protein-coupled receptor states and prediction of downstream efficacy via data-driven modeling

eLife, 2021
Ligand binding stabilizes different G protein-coupled receptor states via a complex allosteric process that is not completely understood. Here, we have derived free energy landscapes describing activation of the β2 adrenergic receptor bound to ligands ...
Oliver Fleetwood, Jens Carlsson, Lucie Delemotte   +2 more
doaj   +1 more source

Licraside as novel potent FXR agonist for relieving cholestasis: structure-based drug discovery and biological evaluation studies

Frontiers in Pharmacology, 2023
Cholestasis is a common clinical disease caused by a disorder in bile acids (BAs) homeostasis, which promotes its development. The Farnesoid X receptor (FXR) plays a critical role in regulating BAs homeostasis, making it an essential target for ...
Lili Xi, Axi Shi, Tiantian Shen, Guoxu Wang, Yuhui Wei, Jingjing Guo   +5 more
doaj   +1 more source

Reconciling intrinsic properties of activating TNF receptors by native ligands versus synthetic agonists

Frontiers in Immunology, 2023
The extracellular domain of tumor necrosis factor receptors (TNFR) generally require assembly into a homotrimeric quaternary structure as a prerequisite for initiation of signaling via the cytoplasmic domains.
George Fromm, Suresh de Silva, Taylor H. Schreiber   +2 more
doaj   +1 more source

In Vitro and In Silico Characterization of G-Protein Coupled Receptor (GPCR) Targets of Phlorofucofuroeckol-A and Dieckol

Marine Drugs, 2021
Phlorotannins are polyphenolic compounds in marine alga, especially the brown algae. Among numerous phlorotannins, dieckol and phlorofucofuroeckol-A (PFF-A) are the major ones and despite a wider biological activity profile, knowledge of the G protein ...
Pradeep Paudel, Su Hui Seong, Se Eun Park, Jong Hoon Ryu, Hyun Ah Jung, Jae Sue Choi   +5 more
doaj   +1 more source

Characterization of TR‐107, a novel chemical activator of the human mitochondrial protease ClpP

Pharmacology Research & Perspectives, 2022
We recently described the identification of a new class of small‐molecule activators of the mitochondrial protease ClpP. These compounds synthesized by Madera Therapeutics showed increased potency of cancer growth inhibition over the related compound ...
Emily M. J. Fennell, Lucas J. Aponte‐Collazo, Joshua D. Wynn, Kristina Drizyte‐Miller, Elisa Leung, Yoshimi Endo Greer, Paul R. Graves, Andrew A. Iwanowicz, Hani Ashamalla, Ekhson Holmuhamedov, Henk Lang, Donald S. Karanewsky, Channing J. Der, Walid A. Houry, Stanley Lipkowitz, Edwin J. Iwanowicz, Lee M. Graves   +16 more
doaj   +1 more source

A TNFR2-Specific TNF Fusion Protein With Improved In Vivo Activity

Frontiers in Immunology, 2022
Tumor necrosis factor (TNF) receptor-2 (TNFR2) has attracted considerable interest as a target for immunotherapy. Indeed, using oligomeric fusion proteins of single chain-encoded TNFR2-specific TNF mutants (scTNF80), expansion of regulatory T cells and ...
Juan Gamboa Vargas, Juan Gamboa Vargas, Jennifer Wagner, Haroon Shaikh, Haroon Shaikh, Isabell Lang, Juliane Medler, Mohamed Anany, Mohamed Anany, Tim Steinfatt, Josefina Peña Mosca, Josefina Peña Mosca, Stephanie Haack, Julia Dahlhoff, Maike Büttner-Herold, Carolin Graf, Estibaliz Arellano Viera, Hermann Einsele, Harald Wajant, Andreas Beilhack, Andreas Beilhack   +20 more
doaj   +1 more source

Binding and functional structure-activity similarities of 4-substituted 2,5-dimethoxyphenyl isopropylamine analogues at 5-HT2A and 5-HT2B serotonin receptors

Frontiers in Pharmacology, 2023
Certain 4-substituted analogs of 1-(2,5-dimethoxyphenyl)isopropylamine (2,5-DMA) are psychoactive classical hallucinogens or serotonergic psychedelic agents that function as human 5-HT2A (h5-HT2A) serotonin receptor agonists.
Prithvi Hemanth, Pallavi Nistala, Vy T. Nguyen, Jose M. Eltit, Richard A. Glennon, Małgorzata Dukat   +5 more
doaj   +1 more source

Functional Stoichiometry at the Nicotinic Receptor. The Photon Cross Section for Phase 1 Corresponds to Two Bis-Q Molecules per Channel [PDF]

, 1982
These experiments examine changes in the agonist-induced conductance that occur when the agonist-receptor complex is perturbed. Voltage-clamped Electrophorus electroplaques are exposed to the photoisomerizable agonist trans-Bis-Q A 1-µs laser flash ...
Lester, Henry A., Sheridan, Robert E.
core   +1 more source