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Memory Studies, 2016 Building on Mouffe’s critique of cosmopolitanism, this article argues that a cosmopolitan mode of remembering, far from having superseded the antagonistic mode associated with ‘first modernity’ in the European context, has proved unable to prevent the rise of, and is being increasingly challenged by, new antagonistic collective memories constructed by
Cento Bull, Anna, Hansen, Hans Lauge
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, 2016 History suggests β agonists, the cognate ligand of the β2 adrenoceptor, have been used as bronchodilators for around 5,000 years, and β agonists remain today the frontline treatment for asthma and chronic obstructive pulmonary disease (COPD). The β agonists used clinically today are the products of significant expenditure and over 100 year's intensive ...
Charlotte K. Billington +2 more
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Beta-Adrenergic Agonists [PDF]
Pharmaceuticals, 2010 Inhaled β2-adrenoceptor (β2-AR) agonists are considered essential bronchodilator drugs in the treatment of bronchial asthma, both as symptoms-relievers and, in combination with inhaled corticosteroids, as disease-controllers. In this article, we first review the basic mechanisms by which the β2-adrenergic system contributes to the control of airway ...
Giovanni Barisione +3 more
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Deoxyguanosine is a TLR7 agonist [PDF]
European Journal of Immunology, 2019 AbstractToll‐like receptor 7 (TLR7) is an innate immune sensor for single‐strand RNA (ssRNA). Recent structural analysis revealed that TLR7 has an additional binding site for nucleosides such as guanosine, and is activated when both guanosine and ssRNA bind.
Jan Rehwinkel +4 more
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Agonists and Partial Agonists of Rhodopsin: Retinals with Ring Modifications [PDF]
Biochemistry, 2005 Activation of the visual pigment rhodopsin is initiated by isomerization of its retinal chromophore to the all-trans geometry, which drives the conformation of the protein to the active state. We have examined by FTIR spectroscopy the impact of a series of modifications at the ring of retinal on the activation process and on molecular interactions ...
Vogel, Reiner +4 more
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Agonist binding, agonist affinity and agonist efficacy at G protein‐coupled receptors [PDF]
British Journal of Pharmacology, 2008 Measurements of affinity and efficacy are fundamental for work on agonists both in drug discovery and in basic studies on receptors. In this review I wish to consider methods for measuring affinity and efficacy at G protein coupled receptors (GPCRs).
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Activation Pathways of Agonists, Partial Agonists and Inverse Agonist in Beta1 and Beta2 Adrenergic Receptors [PDF]
Biophysical Journal, 2010 Modulation of cell signaling by ligands of different efficacies via G-protein coupled receptors (GPCRs), depends intrinsically on the effect of the ligand on the dynamics between the multiple conformational states of these proteins. Ligands with different efficacies can remodel the energy landscape of the receptors, thereby perturbing this ...
Supriyo Bhattacharya, Nagarajan Vaidehi
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The mechanics of agonistic muscles [PDF]
Journal of Biomechanics, 2018 In this study, we tested two assumptions that have been made in experimental studies on muscle mechanics: (i) that the torque-angle properties are similar among agonistic muscles crossing a joint, and (ii) that the sum of the torque capacity of individual muscles adds up to the torque capacity of the agonist group.
Heiliane de Brito Fontana +4 more
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Diabetes Care, 2011 The thiazolidinediones pioglitazone and rosiglitazone were introduced into global markets in 1999–2000; we now have over 10 years of experience with them. The safety issues that it was fashionable to focus on at that time were abnormalities of liver function as a result of the rare but serious side effects of troglitazone, the thiazolidinedione then on
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On agonistic narratives of migration
International Journal of Cultural Studies, 2020 The aim of this article is to apply the concept of agonism to the study of migration and migration narratives in order to shed new light upon a complex field and contribute to the countering of neo-nationalist right-wing populism. Following Chantal Mouffe, the author argues that agonistic narrative traits can be found in already existing cultural ...
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