Results 131 to 140 of about 1,168,781 (390)

Differential actions ofm and n cholinergic agonists on the brainstem activating system [PDF]

, 1969
Hiroshi Kawamura, Edward F. Domino
openalex   +1 more source

Safety of PPAR Agonists

Diabetes Care, 2011
The thiazolidinediones pioglitazone and rosiglitazone were introduced into global markets in 1999–2000; we now have over 10 years of experience with them. The safety issues that it was fashionable to focus on at that time were abnormalities of liver function as a result of the rare but serious side effects of troglitazone, the thiazolidinedione then on
openaire   +4 more sources

Geometrically Controlled WNT Activation Drives Intestinal Morphogenesis

Advanced Healthcare Materials, EarlyView.
Crypt‐villi‐like morphogenesis can be driven and controlled via architectural patterns in colorectal cells with the use of digital light processing printing. The resulting mini tissues exhibit budding structures and functionality, as evidenced by increased mucin expression.
Nathaniel C. Burmas, Arlyn M. Fabian, Amoli Vanavadiya, Quinton Smith   +3 more
wiley   +1 more source

Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells into Osteoblasts

Molecules, 2019
The modulators of farnesoid X receptor (FXR), a bile acid receptor, regulate various biological processes including bile acid metabolism, and are associated with the control of fatty liver and osteoporosis.
Ko Fujimori, Yusuke Iguchi, Yukiko Yamashita, Keigo Gohda, Naoki Teno   +4 more
doaj   +1 more source

Cholinergic agonist-antagonist interactions on neocortical and limbic EEG activation [PDF]

, 1967
Yamamoto Kjen-Ichi, Edward F. Domino
openalex   +1 more source

Biomimetic Scaffolds with Dual Gradients of Biological Effectors for Tendon‐to‐Bone Repair

Advanced Healthcare Materials, EarlyView.
The authors have developed a biomimetic scaffold with dual gradients through a diffusion‐driven method. The scaffold features funnel‐shaped microchannels for cell infiltration, while the dual gradients synergetically induce the graded differentiation of mesenchymal stem cells into osteoblasts, chondrocytes, and tenocytes, allowing for a seamless ...
Min Hao, Yidan Chen, Stavros Thomopoulos, Younan Xia   +3 more
wiley   +1 more source

Low Molecular Weight mRNA Encodes a Protein That Controls Serotonin 5-HT_(1c) and Acetylcholine M_1 Receptor Sensitivity in Xenopus Oocytes [PDF]

, 1991
Serotonin 5-HT_(1c) and acetylcholine M_1 receptors activate phosphoinositidase, resulting in an increased formation of IP_3 and 1,2 diacylglycerol.
Davidson, N., Hoger, J. H., Labarca, C., Lester, H. A., Walter, A. E., Yu, L.   +5 more
core  

Stochastic Chemical Reactions in Micro-domains

, 2004
Traditional chemical kinetics may be inappropriate to describe chemical reactions in micro-domains involving only a small number of substrate and reactant molecules.
D. Holcman, Karlin S., Kleinrock L., Matkowsky B. J., Matthews G., Saaty T. L., Schuss Z., Z. Schuss   +7 more
core   +2 more sources

Analgesic effectiveness of the narcotic agonist‐antagonists. [PDF]

, 1979
RW Houde
openalex   +1 more source

The evolution of β2-agonists

Respiratory Medicine, 2001
Beta-agonists have been widely used in the treatment of asthma for many years Although concerns have been expressed over their safety based largely upon epidemics of increased mortality in asthmatics associated with high doses of isoprenaline in the 1960s and fenoterol in the 1970s and 1980s, the specific beta2-agonists are vital drugs in asthma ...
openaire   +2 more sources