Results 151 to 160 of about 512,073 (249)

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Advanced Science, EarlyView.
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou   +12 more
wiley   +1 more source

OX40/OX40L: a new target for tumor immunotherapy and its clinical research progress. [PDF]

Front Oncol
Yuan Z, Pan Y, Yuan H, Gong A.
europepmc   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Spatially diffuse cAMP signalling with oppositely biased GLP-1 receptor agonists in β-cells despite differences in receptor localisation. [PDF]

Mol Metab
Chen S, Lobato CB, Wong C, Manchanda Y, Viloria K, Davies I, Andersen DB, Ast J, Sloop KW, Hodson DJ, Broichhagen J, Bloom S, Holst JJ, Tan T, Tomas A, Jones B.   +15 more
europepmc   +1 more source

Supplementary Figure S13 from CD27 Agonist Antibodies Mediate Clinical Responses through Intratumoral Stimulation in B-cell Malignancies: Multicenter RiVa Trial

Lara E. Buermann, Louise Stanton, Matthew Rose‐Zerilli, Kerensa Thorne, Adam Coleman, Anna H. Turaj, Joshua Caddy, Christopher Wignall, Nicole Keyworth, Zoë J. Konn, Pam McKay, Wendy Osborne, Kim Linton, Patrick Medd, Robert Lown, Andrew Davies, Peter Johnson, Aymen Al‐Shamkhani, Mark S. Cragg, Graham P. Collins, Tibor Keler, Michael Yellin, Andrew J. Gentles, Gareth Griffiths, Sean H. Lim   +24 more
openalex   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Mapping the Agonist Binding Site of the Nicotinic Acetylcholine Receptor [PDF]

, 2000
Deirdre Sullivan, Jonathan B. Cohen
openalex   +1 more source

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source

Shifting the PPARγ conformational ensemble toward a transcriptionally repressive state improves covalent inhibitor efficacy. [PDF]

Elife
Arifova L, MacTavish BS, Laughlin Z, Karadi Girdhar MN, Shang J, Li MH, Yu X, Zhu D, Kamenecka TM, Kojetin DJ.   +9 more
europepmc   +1 more source

An oral, liver-restricted LXR inverse agonist for dyslipidemia: preclinical development and phase 1 trial

Xiaoxu Li, Giorgia Benegiamo, Archana Vijayakumar, NATALIE SRODA, Masaki Kimura, Ryan S. Huss, STEVE WENG, Eisuke Murakami, Brian J. Kirby, Giacomo V. G. von Alvensleben, Claus Kremoser, Edward Gane, Meritxell Huch, Robert P. Myers, G. Mani Subramanian, Johan Auwerx   +15 more
openalex   +1 more source