Results 191 to 200 of about 1,168,781 (390)
National and State Treatment Need and Capacity for Opioid Agonist Medication-Assisted Treatment.
American Journal of Public Health, 2015 Christopher M. Jones +3 more
semanticscholar +1 more source
Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology
Advanced Science, EarlyView.This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou +14 more
wiley +1 more source
The five primary prostaglandins stimulate contractions and phasic activity of the urinary bladder urothelium, lamina propria and detrusor [PDF]
, 2020 Chess-Williams, Russ +2 more
core +1 more source
Advanced Science, EarlyView.The flavonoid compound LW‐213 exerts its antitumor effects through a novel mechanism involving lysosomal‐ER calcium regulation. Specifically, LW‐213 binds to LIMP2, which induces perinuclear clustering of lysosomes and facilitates calcium‐mediated lysosome‐ER interactions.
Meng‐yuan Zhu +8 more
wiley +1 more source
Stimulation of Cultured Endothelial Cell Proliferation and Metabolism by Platelets and Vasoactive Agonists [PDF]
, 1977 David Sheṕro, Patricia A. D’Amore
openalex +1 more source
Advanced Science, EarlyView.This study develops an a red/far‐red light‐controlled iPSC‐based vaccines (RIVA) based on the chimeric photosensory protein FnBphP and its interaction partner LDB3 for cancer immunotherapy. The RIVA preserves the multiple intrinsic tumor antigens of iPSCs and enables optogenetic control of the expression of the immune adjuvant type I interferon β under
Longliang Qiao +17 more
wiley +1 more source
Advanced Science, EarlyView.To maximize the efficacy of cancer vaccines, adjuvants, collection, lysis, purification, oxidation, loading sites, and sizes, etc., are investigated. The optimized cancer nanovaccines loading whole tumor antigens can cure all or most tumor‐bearing mice in multiple mouse cancer models.
Xiangxiang Xu +13 more
wiley +1 more source