Results 191 to 200 of about 419,324 (239)

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Binding pose depth modulates photoswitchable ligands' efficacy at the 5-HT_2A receptor. [PDF]

Commun Chem
Weber V, Salvadori G, Natale F, Gerwe H, Decker M, Carloni P, Rossetti G.   +6 more
europepmc   +1 more source

Revitalizing GIP: Therapeutic Potential in Metabolic and Neurodegenerative Disorders. [PDF]

Diabetes Metab Syndr Obes
Qiao Y, Zhou F, Mao T, Gao L.
europepmc   +1 more source

The metabolic dysfunction-associated steatohepatitis (MASH) drug resmetirom exhibits broad nuclear receptor activity with minimal functional impact. [PDF]

Sci Rep
Kärcher A, Isigkeit L, Bandomir NC, Schubert-Zsilavecz M, Heitel P.   +4 more
europepmc   +1 more source

Ligand-specific activation trajectories dictate GPCR signalling in cells. [PDF]

Nature
Thomas R, Jacoby PS, De Faveri C, Derieux C, Liebing AD, Melkes B, Martini HJ, Bermúdez M, Stäubert C, Lohse MJ, Coin I, Bock A.   +11 more
europepmc   +1 more source

Topical Volumizing Cream Improves Facial Volume and Skin Health in Adults With Rapid Weight Loss From Pharmacologic (GLP-1/GIP Agonists), Surgical, or Behavioral Interventions. [PDF]

J Cosmet Dermatol
Nguyen N, Aguilar A, Afzal N, Lee A, Akram W, Duong MN, Sivamani RK.   +6 more
europepmc   +1 more source