Results 211 to 220 of about 1,168,781 (390)
Chronotropic responsiveness of developing sinoatrial and ventricular rat myocytes to autonomic agonists following adrenergic and cholinergic innervation in vitro. [PDF]
, 1989 Dianne L. Atkins, William J. Marvin
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Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor
Nature, 1995 J. Meunier +13 more
semanticscholar +1 more source
Advanced Science, EarlyView.Vascular smooth muscle cells (VSMCs)‐specific deficiency of PP2Acα exacerbates aortic aneurysm and dissection (AAD) by promoting phenotypic switching through AKT1‐mediated phosphorylation and stabilization of Kruppel‐like factor 4 (KLF4). Reduced PP2Acα enhances KLF4 ubiquitination resistance, suppressing VSMC contractile genes and accelerating aortic ...
Wei‐Peng Hu +7 more
wiley +1 more source
Longitudinal analysis of pupillometry according to type of pharmacotherapy in Parkinson's disease patients. [PDF]
Sci RepBartošová O +7 more
europepmc +1 more source
Advanced Science, EarlyView.Elevated lactate in diabetes activates the GPR132‐Src pathway in macrophages, inducing macrophage senescence and further enhancing foam cell formation. This mechanism exacerbates atherosclerotic progression. Abstract Diabetes is widely acknowledged as a significant risk factor for atherosclerosis, facilitating plaque formation through various ...
Xiaofeng Ge +10 more
wiley +1 more source
Agonist-Dependent Desensitization of Myometrialβ -Adrenergic Catecholamine-Sensitive Adenylate Cyclase1 [PDF]
, 1980 Larry C. Levin +2 more
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Advanced Science, EarlyView.Lynch et al., identified novel targets on the wake‐promoting pathways that can effectively treat pain‐induced sleep disturbances. The authors demonstrated that Calcitonin gene‐related peptide‐expressing neurons (CGRP) in the external lateral parabrachial nucleus (PBelCGRP) serve as the primary relay node for pain stimuli that cause sleep disruption ...
Nicole Lynch +13 more
wiley +1 more source
Advanced Science, EarlyView.Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang +6 more
wiley +1 more source