Results 211 to 220 of about 1,200,697 (382)

The influence of endometrial thickness on clinical pregnancy outcomes in early-follicular long-acting and midluteal short-acting GnRH agonist long protocols: a large retrospective study. [PDF]

Front Endocrinol (Lausanne)
Wang C, Yang C, Dai W, Han L, Kong H, Yao G, Wang X, Bu Z, Peng Y, Zhai J.   +9 more
europepmc   +1 more source

Discovery of phenylsulfonyl acetic acid derivatives with improved efficacy and safety as potent free fatty acid receptor 1 agonists for the treatment of type 2 diabetes

, 2017
Zheng Li, Chunxia Liu, Xue Xu, Qianqian Qiu, Xin Su, Yuxuan Dai, Jianyong Yang, Huilan Li, Wei Shi, Chen Liao, Miaobo Pan, Wenlong Huang, Hai Qian   +12 more
openalex   +1 more source

GPR119 agonist enhances gefitinib responsiveness through lactate-mediated inhibition of autophagy [PDF]

, 2018
Ji Hye Im, Keon Wook Kang, Sun Young Kim, Yoon Gyoon Kim, Yong An, Sunghyouk Park, Byung Hwa Jeong, Song‐Yi Choi, Jinsun Lee, Keon Wook Kang   +9 more
openalex   +1 more source

Chiral Cyclic Aliphatic Linkers as Building Blocks for Selective Dopamine D₂ or D₃ Receptor Agonists

, 2021
Francisco O. Battiti, Saheem A. Zaidi, Vsevolod Katritch, Amy Hauck Newman, Alessandro Bonifazi   +4 more
openalex   +2 more sources

Deoxynivalenol Exposure Leads to Abnormal Renal Tubular Autophagy Flow

Advanced Science, EarlyView.
DON exposure disrupts the initiation of renal autophagy by inhibiting the formation of autophagosomes, thereby impairing mitochondrial degradation. Damaged mitochondria increase oxidative stress, reduce ferroptosis resistance, and cause lysosomal Fe2⁺ accumulation, further disrupting autophagy.
Hao Chen, Xintong Zhou, Jun Ma
wiley   +1 more source

Nalfurafine is Aversive at Antinociceptive Doses in Mice. [PDF]

Pharmacol Res Perspect
Kuijer EJ, Marinelli LH, Bailey SJ, Heal DJ, Smith S, Wonnacott S, Bailey CP.   +6 more
europepmc   +1 more source

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

Advanced Science, EarlyView.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao, Zongmin Jiang, Xupeng Liu, Liping Zhang, Siyu Guo, Yu Chen, Lanfang Luo, Shilin Ma, Peng Wang, Ng Shyh‐Chang   +9 more
wiley   +1 more source

Differential potentiation of odor aversion and yawning by melanocortin 4 receptor signaling in distinct regions of the ventral striatum. [PDF]

Front Neurosci
Alam MT, Ahasan MM, Shimizu S, Murata Y, Taniguchi M, Yamaguchi M.   +5 more
europepmc   +1 more source

The marionette mechanism of domain–domain communication in the antagonist, agonist, and coactivator responses of the estrogen receptor

, 2023
Xun Chen, Shikai Jin, Mingchen Chen, Carlos Bueno, Peter G. Wolynes   +4 more
openalex   +2 more sources

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source