Results 21 to 30 of about 833,545 (343)

The effect of adding inhaled corticosteroids to tiotropium and long-acting beta(2)-agonists for chronic obstructive pulmonary disease (Review) [PDF]

, 2011
BackgroundLong-acting bronchodilators comprising long-acting beta(2)-agonists and the anticholinergic agent tiotropiumare commonly used, either on their own or in combination, for managing persistent symptoms of chronic obstructive pulmonary disease ...
Aaron, Aaron, Agarwal, Akazawa, Appleton, Barr, Beeh, Berger, Briggs, Calverley, Dalal, Effing, Higgins, Hutchinson, Johnson, Kaplan, Lacasse, Meer, Najafzadeh, Najafzadeh, Nannini, Nannini Luis, Proskocil, Rodrigo, Rodrigo, Roisman, Singh, Singh, Tanaka, Tashkin, Wallukat, Welsh, Yang   +32 more
core   +1 more source

ChemR23 activation reprograms macrophages toward a less inflammatory phenotype and dampens carcinoma progression

Frontiers in Immunology, 2023
IntroductionTumor Associated Macrophages (TAM) are a major component of the tumor environment and their accumulation often correlates with poor prognosis by contributing to local inflammation, inhibition of anti-tumor immune response and resistance to ...
Margot Lavy, Vanessa Gauttier, Alison Dumont, Florian Chocteau, Sophie Deshayes, Judith Fresquet, Virginie Dehame, Virginie Dehame, Isabelle Girault, Charlène Trilleaud, Stéphanie Neyton, Caroline Mary, Philippe Juin, Philippe Juin, Nicolas Poirier, Sophie Barillé-Nion, Christophe Blanquart   +16 more
doaj   +1 more source

Comparison of antimüllerian hormone levels and antral follicle count as predictor of ovarian response to controlled ovarian stimulation in good-prognosis patients at individual fertility clinics in two multicenter trials [PDF]

, 2015
Objective To compare antimüllerian hormone (AMH) and antral follicle count (AFC) as predictors of ovarian response to controlled ovarian stimulation at individual fertility clinics.
Arce, Joan-Carles, Klein, Bjarke M., Nelson, Scott M.   +2 more
core   +1 more source

Agonism of 4-1BB for immune therapy: a perspective on possibilities and complications

Frontiers in Immunology, 2023
Costimulatory receptors on immune cells represent attractive targets for immunotherapy given that these molecules can increase the frequency of individual protective immune cell populations and their longevity, as well as enhance various effector ...
Shahram Salek-Ardakani, Dirk M. Zajonc, Michael Croft, Michael Croft   +3 more
doaj   +1 more source

β2 Agonists [PDF]

, 2016
History suggests β agonists, the cognate ligand of the β2 adrenoceptor, have been used as bronchodilators for around 5,000 years, and β agonists remain today the frontline treatment for asthma and chronic obstructive pulmonary disease (COPD). The β agonists used clinically today are the products of significant expenditure and over 100 year's intensive ...
Charlotte K. Billington, Ian P. Hall, Raymond B. Penn   +2 more
openaire   +3 more sources

Fingerprinting heterocellular β-adrenoceptor functional expression in the brain using agonist activity profiles

Frontiers in Molecular Biosciences, 2023
Noradrenergic projections from the brainstem locus coeruleus drive arousal, attentiveness, mood, and memory, but specific adrenoceptor (AR) function across the varied brain cell types has not been extensively characterized, especially with agonists. This
Rachel A. Matt, Frederick G. Westhorpe, Rosemary F. Romuar, Payal Rana, Joel R. Gever, Anthony P. Ford   +5 more
doaj   +1 more source

RIG-I agonist SLR10 promotes macrophage M1 polarization during influenza virus infection

Frontiers in Immunology, 2023
RationaleA family of short synthetic, triphosphorylated stem-loop RNAs (SLRs) have been designed to activate the retinoic-acid-inducible gene I (RIG-I) pathway and induce a potent interferon (IFN) response, which may have therapeutic potential.
Wenxin Wu, Wei Zhang, Jeremy S. Alexandar, J. Leland Booth, Craig A. Miller, Chao Xu, Jordan P. Metcalf, Jordan P. Metcalf, Jordan P. Metcalf   +8 more
doaj   +1 more source

Anticancer Effect of STING Agonist-Encapsulated Liposomes on Breast Cancer

Molecules, 2023
Breast cancer is one of the most common cancers worldwide, posing a serious threat to human health. Recently, innate immunity has become a widely discussed topic in antitumor research.
Jibing Zhang, Xiao Cui, Yujiao Huang, Xiangdong Xu, Changshun Feng, Jun Li   +5 more
doaj   +1 more source

Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells into Osteoblasts

Molecules, 2019
The modulators of farnesoid X receptor (FXR), a bile acid receptor, regulate various biological processes including bile acid metabolism, and are associated with the control of fatty liver and osteoporosis.
Ko Fujimori, Yusuke Iguchi, Yukiko Yamashita, Keigo Gohda, Naoki Teno   +4 more
doaj   +1 more source

α1D-Adrenoceptors are responsible for the high sensitivity and the slow time-course of noradrenaline-mediated contraction in conductance arteries [PDF]

, 2013
The objective of this study was to determine whether the different time-course characteristics of α1-adrenoceptor-mediated contraction in arteries can be related to the subtypes involved.
Alexander, Arévalo-León, Cavalli, Chalothorn, Chen, Cotecchia, Daly, Deighan, Docherty, García-Cazarín, García-Sainz, García-Sainz, García-Sainz, Gisbert, Gisbert, Gisbert, Gisbert, Goldstein, Hawrylyshyn, Hein, Hosoda, Hrometz, Hussain, Keffel, Kenny, Koshimizu, Lachnit, Lyssand, Lyssand, Lyssand, Martinez-Rivelles, Martí, McCune, Methven, Methven, Michelotti, Monto, Noguera, Noguera, Philipp, Piascik, Piascik, Pérez-Aso, Rudner, Schwinn, Stassen, Taguchi, Tanaka, Tanoue, Tanoue, Theroux, Yamamoto, Zhong, Ziani   +53 more
core   +1 more source