Results 181 to 190 of about 339,684 (208)
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A novel radiofluorinated agouti-related protein for tumor angiogenesis imaging
Amino Acids, 2012A novel protein scaffold based on the cystine knot domain of the agouti-related protein (AgRP) has been used to engineer mutants that can bind to the α(v)β(3) integrin receptor with high affinity and specificity. In the current study, an (18)F-labeled AgRP mutant (7C) was prepared and evaluated as a positron emission tomography (PET) probe for imaging ...
Han, Jiang +10 more
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Central and peripheral interactions between the agouti-related protein and leptin
Biochemical and Biophysical Research Communications, 2004The agouti-related protein (AgRP) is a powerful appetite modulator expressed in the hypothalamus and the adrenal gland and regulated by leptin. Here we report the robust expression of AgRP in epididymal fat and its upregulation in this tissue by feeding rather than by fasting.
Chantal, Charbonneau +3 more
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A Role for the Agouti-Related Protein Promoter in Obesity and Type 2 Diabetes
Biochemical and Biophysical Research Communications, 2001The murine Agouti-Related Protein (mAGRP) is upregulated in obese and diabetic mice and can stimulate hyperphagia when overexpressed in transgenic models. Here we report upstream nucleotide sequences of the human hAGRP gene with putative recognition sites for transcription factors including a site for the STAT transactivators. A polymorphism (-38C-->T)
D K, Mayfield +5 more
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Molecular Interaction of Agouti Protein and Agouti-Related Protein with Human Melanocortin Receptors
Biochemistry, 1998Agouti protein and the Agouti-related protein (AGRP) are antagonists of the melanocortin-3 receptor and melanocortin-4 receptor. Both proteins contain 10 cysteines in the C-terminal domain arranged in five disulfide bonds. One possible arrangement of the disulfide bonds predicts an octapeptide loop, and the chemical properties of four residues within ...
M R, Tota +6 more
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Cognitive flexibility and Agouti-related protein in adolescent patients with anorexia nervosa
Psychoneuroendocrinology, 2011Cognitive flexibility and the flexible learning and relearning of stimulus-reward-associations are important for decision-making and goal-directed behavior. Studies on patients with anorexia nervosa (AN) have shown difficulties in cognitive functions associated with malnutrition and extreme underweight.
Lea, Sarrar +5 more
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Novel Agouti-Related-Protein-Based Melanocortin-1 Receptor Antagonist
Journal of Medicinal Chemistry, 2001The melanocortin receptors are G-protein coupled receptors (GPCRs) that activate the cAMP signal transduction pathway and are stimulated by the melanocortin agonist alpha-melanocyte stimulating hormone (alpha-MSH). Members of these melanocortin receptors are antagonized by agouti (ASP) and agouti-related protein (AGRP), which are the only known ...
R, Thirumoorthy +5 more
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Treadmill Exercise’s Reduction of Agouti-Related Protein Expression in Rat Liver
International Journal of Sport Nutrition and Exercise Metabolism, 2009Agouti-related protein (AGRP) is an orexigenic peptide secreted from the arcuate nucleus (ARC) of the hypothalamus. AGRP increases food intake and plays a role in energy balance, adiposity, weight gain, and growth-hormone release. The objective of the current study was to examine the effects of running exercise on resting hepatic, fundus, and pancreas ...
Abbass, Ghanbari-Niaki +6 more
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