Results 181 to 190 of about 10,922 (223)

Changes in Hypothalamic Agouti-Related Protein (AGRP), but not α-MSH or Pro-Opiomelanocortin Concentrations in Dietary-Obese and Food-Restricted Rats

Biochemical and Biophysical Research Communications, 1999
Melanocortin-4 receptor (MC4-R) density is thought to be regulated by synaptic availability of endogenous agonist, alpha-melanocyte-stimulating hormone (alpha-MSH), and also by agouti-related protein (AGRP), which acts as a competitive antagonist. As hypothalamic MC4-R have been implicated in the regulation of energy balance, we examined concentrations
J A, Harrold, G, Williams, P S, Widdowson   +2 more
openaire   +4 more sources

Chronic CNS administration of Agouti-related protein (Agrp) reduces energy expenditure

International Journal of Obesity, 2003
To investigate whether the Agouti-related protein (Agrp), the melanocortin receptor antagonist, alters oxygen consumption, as a measure of energy expenditure.A 7-day intracerebroventricular administration of Agrp (1 nmol/day) in rats.Oxygen consumption was determined in closed-circuit respirometers on days 1 and 8.
C J, Small, Y L, Liu, S A, Stanley, I P, Connoley, A, Kennedy, M J, Stock, S R, Bloom   +6 more
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Agouti‐Related Proteins (AGRPs) and Agouti‐Signaling Peptide (ASIP) in Fish and Chicken

Annals of the New York Academy of Sciences, 2005
Abstract: We performed an intensive search on sequence databases to identify orthologues of ASIP and AGRP peptides in a number of different species, revealing a number of genomic fragments coding for the C‐terminal part of agouti‐related motifs, different from annotated peptide sequences, including one fragment from chicken, two from zebrafish, two ...
Janis, Klovins, Helgi B, Schiöth
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Determination of Disulfide Structure in Agouti-Related Protein (AGRP) by Stepwise Reduction and Alkylation

Biochemistry, 1998
The agouti-related protein gene (Agrp) plays an important role in body weight regulation. The mature human protein is a single polypeptide chain of 112 amino acid residues, consisting of an N-terminal acidic region and a unique C-terminal cysteine-rich domain.
E J, Bures, J O, Hui, Y, Young, D T, Chow, V, Katta, M F, Rohde, L, Zeni, R D, Rosenfeld, K L, Stark, M, Haniu   +9 more
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Enterostatin affects cyclic AMP and ERK signaling pathways to regulate Agouti-related Protein (AgRP) expression

Peptides, 2009
Enterostatin, a gut-brain peptide, inhibits dietary fat intake in rats. The purpose of this study was to identify the intracellular signaling pathways that are responsive to enterostatin and that modulate the effects of enterostatin on the expression of Agouti-related protein (AgRP).
Miejung, Park, Hyoungil, Oh, David A, York   +2 more
openaire   +2 more sources

Disulfide assignment of the C‐terminal cysteine knot of agouti‐related protein (AGRP) by direct sequencing analysis

The Journal of Peptide Research, 1999
Abstract: We have assigned the disulfide structure of Md‐65 agouti‐related protein (Md65‐AGRP) using differential reduction and alkylation followed by direct sequencing analysis. The mature human AGRP is a single polypeptide chain of 112 amino acid residues, consisting of an N‐terminal acidic region and a unique C‐terminal cysteine‐rich domain.
Y, Young, L, Zeni, R D, Rosenfeld, K L, Stark, M F, Rohde, M, Haniu   +5 more
openaire   +2 more sources

Forebrain agouti-related protein (AgRP) injections increase appetitive but not consummatory feeding behaviors in the rat.

Appetite, 2007
Agouti-related protein (AgRP), an endogenous melanocortin receptor inverse agonist, stimulates feeding. Exogenous application promotes ingestion over an extended multi-day period. In the current study, several methods were employed to determine the effects of lateral (LV) or third ventricle (3 V) injections of AgRP on appetitive and consummatory ...
J.P. Baird, P.V. Holmes, K. Wickwire, R. Dailey, S.Q. Giraudo   +4 more
openaire   +1 more source

Structural Characterization and Pharmacology of a Potent (Cys101−Cys119, Cys110−Cys117) Bicyclic Agouti-Related Protein (AGRP) Melanocortin Receptor Antagonist

Journal of Medicinal Chemistry, 2004
Agouti-related protein (AGRP) is one of two known naturally occurring antagonists of G-protein coupled receptors. AGRP is synthesized in the brain and is an antagonist of the melanocortin-3 and -4 receptors (MC3R, MC4R). These three proteins are involved in the regulation of energy homeostasis and obesity in both mice and humans. The human AGRP protein
Andrzej, Wilczynski, Xiang S, Wang, Rayna M, Bauzo, Zhimin, Xiang, Amanda M, Shaw, William J, Millard, Nigel G, Richards, Arthur S, Edison, Carrie, Haskell-Luevano   +8 more
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Expression of agouti-related protein (AgRP) in the hypothalamus and adrenal gland of the duck (Anas platyrhynchos)

Anatomy and Embryology, 2004
The presence and distribution of agouti-related protein (AgRP) immunoreactivity were investigated in the hypothalamus and adrenal gland of the duck using immunohistochemistry and Western blot analysis. Expression of AgRP mRNA was also studied using reverse transcriptase polymerase chain reaction (RT-PCR).
MIRABELLA, NICOLA, ESPOSITO, VINCENZO, SQUILLACIOTI, CATERINA, DE LUCA, ADRIANA, PAINO, GIUSEPPE   +4 more
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Plasma agouti-related protein (AGRP), growth hormone, insulin responses to a single circuit-resistance exercise in male college students

Peptides, 2007
The ability of acute exercise to stimulate appetite and food intake depends on intensity, duration, and agouti-related protein (AGRP) levels. Fasting, as well as any negative energy balance, has been reported to increase AGRP expression in the arcuate nucleus (ARC) of the hypothalamus and other extra-hypothalamic tissues in human and rats.
Abbass, Ghanbari-Niaki, Saeid, Nabatchian, Mehdi, Hedayati   +2 more
openaire   +2 more sources