Results 191 to 200 of about 10,922 (223)

Increased food intake in growth hormone-transgenic common carp (Cyprinus carpio L.) may be mediated by upregulating Agouti-related protein (AgRP)

General and Comparative Endocrinology, 2013
In fish, food intake and feeding behavior are crucial for survival, competition, growth and reproduction. Growth hormone (GH)-transgenic common carp exhibit an enhanced growth rate, increased food intake and higher feed conversion rate. However, the underlying molecular mechanisms of feeding regulation in GH-transgenic (TG) fish are not clear.
Chengrong, Zhong, Yanlong, Song, Yaping, Wang, Tanglin, Zhang, Ming, Duan, Yongming, Li, Lanjie, Liao, Zuoyan, Zhu, Wei, Hu   +8 more
openaire   +2 more sources

Down-regulated expression of agouti-related protein (AGRP) mRNA in the hypothalamic arcuate nucleus of hyperphagic and obese tub/tub mice

Molecular Brain Research, 2004
A mutation in the mouse tub gene causes a phenotype characterized by maturity-onset obesity, blindness and deafness. The role of the intact tubby protein and the pathogenesis resulting in the phenotype of tub/tub mice remain largely unknown. In this study, we have investigated whether obese tub/tub mice exhibit altered expression levels for agouti ...
M, Bäckberg, N, Madjid, S O, Ogren, B, Meister   +3 more
openaire   +2 more sources

Expression of Agouti‐related Protein (Agrp) and its mRNA in the Hypothalamus and the Adrenal Gland of the Duck (Anas platyrhynchos)

Anatomia, Histologia, Embryologia, 2005
Introduction:  Agouti‐related protein (AGRP) is a neuropeptide involved in the control of body weight. Morphological and pharmacological studies have shown that AGRP is implicated in the central control of feeding behaviour acting as an endogenous antagonist of the alpha‐melanocyte stimulating hormone (α‐MSH), a potent satiety‐inducing factor, at the ...
MIRABELLA, NICOLA, ESPOSITO, VINCENZO, SQUILLACIOTI, CATERINA, DE LUCA, ADRIANA, GERMANO, GIUSEPPE, PAINO, GIUSEPPE   +5 more
openaire   +2 more sources

High-Resolution NMR Structure of the Chemically-Synthesized Melanocortin Receptor Binding Domain AGRP(87−132) of the Agouti-Related Protein^,

Biochemistry, 2001
The agouti-related protein (AGRP) is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic (appetite-stimulating) activity. The cysteine-rich C-terminal domain of this protein, corresponding to AGRP(87-132), contains five disulfide bonds and exhibits receptor binding affinity and ...
J C, McNulty, D A, Thompson, K A, Bolin, J, Wilken, G S, Barsh, G L, Millhauser   +5 more
openaire   +2 more sources

N-Oleoylglycine-Induced Hyperphagia Is Associated with the Activation of Agouti-Related Protein (AgRP) Neuron by Cannabinoid Receptor Type 1 (CB1R)

Journal of Agricultural and Food Chemistry, 2017
N-Acyl amino acids (NAAAs) are conjugate products of fatty acids and amino acids, which are available in animal-derived food. We compared the effects of N-arachidonoylglycine (NAGly), N-arachidonoylserine (NASer), and N-oleoylglycine (OLGly) on in vivo food intake and in vitro [Ca2+]i of Agouti-related protein (AgRP) neurons to identify the role of ...
Junguo Wu, Canjun Zhu, Liusong Yang, Zhonggang Wang, Lina Wang, Songbo Wang, Ping Gao, Yongliang Zhang, Qingyan Jiang, Xiaotong Zhu, Gang Shu   +10 more
openaire   +2 more sources

Pharmacological Characterization of 40 Human Melanocortin-4 Receptor Polymorphisms with the Endogenous Proopiomelanocortin-Derived Agonists and the Agouti-Related Protein (AGRP) Antagonist^,

Biochemistry, 2006
The melanocortin-4 receptor (MC4R) is a G-protein coupled receptor (GPCR) that is expressed in the central nervous system and has a role in regulating energy homeostasis and obesity. Up to a remarkable 6% of morbidly obese adults and children studied possess single nucleotide polymorphisms (SNPs) of the MC4R.
Zhimin, Xiang, Sally A, Litherland, Nicholas B, Sorensen, Bettina, Proneth, Michael S, Wood, Amanda M, Shaw, William J, Millard, Carrie, Haskell-Luevano   +7 more
openaire   +2 more sources

Characterization, tissue distribution, and regulation of agouti-related protein (AgRP), cocaine- and amphetamine-regulated transcript (CART) and neuropeptide Y (NPY) in Atlantic salmon (Salmo salar)

General and Comparative Endocrinology, 2009
Key peptide hormones involved in the control of appetite in vertebrates were identified, their genes characterized and their regulation studied in Atlantic salmon: two agouti-related proteins (AgRP), cocaine- and amphetamine-regulated transcript (CART) and neuropeptide Y (NPY).
Koji, Murashita, Tadahide, Kurokawa, Lars O E, Ebbesson, Sigurd O, Stefansson, Ivar, Rønnestad   +4 more
openaire   +2 more sources

BIOLOGICAL ACTIVITIES OF CHEMICALLY SYNTHESIZED VARIANT OF AGOUTI‐RELATED PROTEIN (AGRP)

Journal of Pediatric Gastroenterology and Nutrition, 1998
Y-K. Yang, D. A. Thompson, J. Wilken, G. S. Barsh, S.B.H. Kent, I. Gantz, C. J. Dickinson   +6 more
openaire   +1 more source

Rapid communication: sequencing of the porcine agouti-related protein (AGRP) gene

Journal of Animal Science, 2002
M J, Halverson, K J, Donelan, N H, Granholm, T M, Cheesbrough, C A, Westby, D M, Marshall   +5 more
openaire   +2 more sources

The Naturally Occurring Melanocortin Antagonist Agouti-Related Protein (AGRP) Possesses Similar and Distinct Interactions at the MC4 Receptor Compared with Melanocortin Agonist

2001
Agouti-related protein (AGRP) is one of two known naturally occurring antagonists of G-protein coupled receptors identified to date, is an antagonist of the melanocortin-4 receptor (MC4R), and is involved in obesity and the regulation of feeding behavior [1,2].
Carrie Haskell-Luevano, Eileen K. Monck, Y.-P. Wan   +2 more
openaire   +1 more source