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Modification of the dominance of agouti to non-agouti in the mouse
Journal of Genetics, 1934The foregoing series of experiments, demonstrating the way in which the phenotypedark arises by inheritance, has shown that this type depends upon the presence of at least two genes: (1) the well-known recessive non-agouti, a, in the heterozygous condition; and (2) one or more dominant or semi-dominant modifying factors, U1 [U2…], whose effect is to ...
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Molecular Interaction of Agouti Protein and Agouti-Related Protein with Human Melanocortin Receptors
Biochemistry, 1998Agouti protein and the Agouti-related protein (AGRP) are antagonists of the melanocortin-3 receptor and melanocortin-4 receptor. Both proteins contain 10 cysteines in the C-terminal domain arranged in five disulfide bonds. One possible arrangement of the disulfide bonds predicts an octapeptide loop, and the chemical properties of four residues within ...
M R, Tota +6 more
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Agouti‐Related Proteins (AGRPs) and Agouti‐Signaling Peptide (ASIP) in Fish and Chicken
Annals of the New York Academy of Sciences, 2005Abstract: We performed an intensive search on sequence databases to identify orthologues of ASIP and AGRP peptides in a number of different species, revealing a number of genomic fragments coding for the C‐terminal part of agouti‐related motifs, different from annotated peptide sequences, including one fragment from chicken, two from zebrafish, two ...
Janis, Klovins, Helgi B, Schiöth
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The agouti gene: turned on to yellow
Trends in Genetics, 1994The agouti locus was first identified as a result of its effects on the type and temporal deposition of coat color pigments in mammals. Many mutations at the murine agouti locus have now been found, some of which not only affect coat color, but also interfere with diverse biological processes leading to diabetes, obesity, tumor susceptibility and ...
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The agouti gene product inhibits lipolysis in human adipocytes via a Ca 2+ ‐dependent mechanism
FASEB Journal, 1998Bingzhong Xue +2 more
exaly