Results 171 to 180 of about 35,433 (223)

Inverse agonist activity of agouti and agouti-related protein

Peptides, 2003
Agouti and agouti-related protein (AgRP) are endogenous antagonists of the melanocortin receptors (MCxR). Previous data showed that recombinant full-length agouti and a synthetic fragment of AgRP, AgRP (83-132), are inverse agonists at the MC1R and MC4R, respectively.
Biao-Xin, Chai, Richard R, Neubig, Glenn L, Millhauser, Darren A, Thompson, Pilgrim J, Jackson, Gregory S, Barsh, Chris J, Dickinson, Ji-Yao, Li, Yu-Mei, Lai, Ira, Gantz   +9 more
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Fecal corticosteroids in agouti and non-agouti deer mice (Peromyscus maniculatus)

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2002
Total and per gram fecal corticosteroid concentrations were determined for agouti and non-agouti deer mice (Peromyscus maniculatus gracilis) over 24 h under normal caging conditions and after exposure to the stress of novel caging. Per gram corticosteroid concentrations, fecal output, and 24-h corticosteroid production were greater in stressed compared
V, Hayssen, J M, Harper, R, DeFina
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Thyroxine levels in agouti and non-agouti deer mice (Peromyscus maniculatus)

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2001
Total thyroxine was assessed by radioimmunoassay for 58 female deer mice of two subspecies (Peromyscus maniculatus bairdii and P. m. gracilis) and two color morphs (agouti and non-agouti). P. m. bairdii of both color-morphs had significantly higher mean thyroxine levels than P. m. gracilis.
J M, Lapseritis, V, Hayssen
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Agouti regulates adipocyte transcription factors

American Journal of Physiology-Cell Physiology, 2001
Agouti is a secreted paracrine factor that regulates pigmentation in hair follicle melanocytes. Several dominant mutations cause ectopic expression of agouti, resulting in a phenotype characterized by yellow fur, adult-onset obesity and diabetes, increased linear growth and skeletal mass, and increased susceptibility to tumors.
R L, Mynatt, J M, Stephens
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Placentation in the Capybara (Hydrochaerus hydrochaeris), Agouti (Dasyprocta aguti) and Paca (Agouti paca)

Placenta, 2002
Placentae of three hystricimorph rodents--capybara, agouti and paca--were examined by conventional histology, immunohistochemistry for cytokeratin and vimentin, and TUNEL staining. The placentae were divided into lobules of labyrinthine syncytium separated by interlobular and marginal trophoblast.
Miglino, M., Carter, A. M., Ferraz, RHD, Machado, MRF   +3 more
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Molecular Interaction of Agouti Protein and Agouti-Related Protein with Human Melanocortin Receptors

Biochemistry, 1998
Agouti protein and the Agouti-related protein (AGRP) are antagonists of the melanocortin-3 receptor and melanocortin-4 receptor. Both proteins contain 10 cysteines in the C-terminal domain arranged in five disulfide bonds. One possible arrangement of the disulfide bonds predicts an octapeptide loop, and the chemical properties of four residues within ...
M R, Tota, T S, Smith, C, Mao, T, MacNeil, R T, Mosley, L H, Van der Ploeg, T M, Fong   +6 more
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Agouti‐Related Proteins (AGRPs) and Agouti‐Signaling Peptide (ASIP) in Fish and Chicken

Annals of the New York Academy of Sciences, 2005
Abstract: We performed an intensive search on sequence databases to identify orthologues of ASIP and AGRP peptides in a number of different species, revealing a number of genomic fragments coding for the C‐terminal part of agouti‐related motifs, different from annotated peptide sequences, including one fragment from chicken, two from zebrafish, two ...
Janis, Klovins, Helgi B, Schiöth
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Peptoid mimics of agouti related protein

Bioorganic & Medicinal Chemistry Letters, 2003
The Agouti Related Protein (AGRP) is an endogenous antagonist of melanocortin-3 and -4 receptors, each of which plays a key role in body weight homeostasis. We designed a peptoid trimer based on AGRP 111-113 in which a single chiral atom is used to partially restrain the backbone structure. Peptoid 5 displaced both radiolabeled Nle4-alpha-MSH (IC(50)=3.
Darren A, Thompson, Biao-Xin, Chai, Hilary L E, Rood, Michael A, Siani, Nicholai R, Douglas, Ira, Gantz, Glenn L, Millhauser   +6 more
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Structures of the Agouti Signaling Protein

Journal of Molecular Biology, 2005
Expression of the agouti signaling protein (ASIP) during hair growth produces the red/yellow pigment pheomelanin. ASIP, and its neuropeptide homolog the agouti-related protein (AgRP) involved in energy balance, are novel, paracrine signaling molecules that act as inverse agonists at distinct subsets of melanocortin receptors. Ubiquitous ASIP expression
Joseph C, McNulty, Pilgrim J, Jackson, Darren A, Thompson, Biaoxin, Chai, Ira, Gantz, Gregory S, Barsh, Philip E, Dawson, Glenn L, Millhauser   +7 more
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Bioactive Motifs of Agouti Signal Protein

Experimental Cell Research, 2000
The switch between the synthesis of eu- and pheomelanins is modulated by the interaction of two paracrine signaling molecules, alpha-melanocyte stimulating hormone (MSH) and agouti signal protein (ASP), which interact with melanocytes via the MSH receptor (MC1R).
V M, Virador, C, Santis, M, Furumura, H, Kalbacher, V J, Hearing   +4 more
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