Results 1 to 10 of about 123,499 (307)

Polyvalent AIDS vaccines. [PDF]

Curr HIV Res, 2010
A major hurdle in the development of a global HIV-1 vaccine is viral diversity. For close to three decades, HIV vaccine development has focused on either the induction of T cell immune responses or antibody responses, and only rarely on both components.
Lu S, Grimes Serrano JM, Wang S.
europepmc   +4 more sources

HIV/AIDS Vaccines: 2018. [PDF]

Clin Pharmacol Ther, 2018
Human immunodeficiency virus (HIV) has infected 76 million people and killed an estimated 35 million. During its 40‐year history, remarkable progress has been made on antiretroviral drugs. Progress toward a vaccine has also been made, although this has yet to deliver a licensed product. In 2007, I wrote a review, HIV AIDS Vaccines: 2007.
Robinson HL.
europepmc   +4 more sources

Analysis of SARS-CoV-2 variants B.1.617: host tropism, proteolytic activation, cell–cell fusion, and neutralization sensitivity

Emerging Microbes and Infections, 2022
SARS-CoV-2 has caused the COVID-19 pandemic. B.1.617 variants (including Kappa and Delta) have been transmitted rapidly in India. The transmissibility, pathogenicity, and neutralization characteristics of these variants have received considerable ...
Li Zhang, Qianqian Li, Jiajing Wu, Yuanling Yu, Yue Zhang, Jianhui Nie, Ziteng Liang, Zhimin Cui, Shuo Liu, Haixin Wang, Ruxia Ding, Fei Jiang, Tao Li, Lingling Nie, Qiong Lu, Jiayi Li, Lili Qin, Yinan Jiang, Yi Shi, Wenbo Xu, Weijin Huang, Youchun Wang   +21 more
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HIV-1 pseudoviruses constructed in China regulatory laboratory

Emerging Microbes and Infections, 2020
To better evaluate HIV-1 vaccines and therapeutics, the National Institutes for Food and Drug Control of China developed a panel of HIV-1 pseudoviruses including 462 viral strains derived from China, covering the majority of contemporaneous subtypes and ...
Jianhui Nie, Weijin Huang, Qiang Liu, Youchun Wang   +3 more
doaj   +1 more source

Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2

Emerging Microbes and Infections, 2020
Pseudoviruses are useful virological tools because of their safety and versatility, especially for emerging and re-emerging viruses. Due to its high pathogenicity and infectivity and the lack of effective vaccines and therapeutics, live SARS-CoV-2 has to
Jianhui Nie, Qianqian Li, Jiajing Wu, Chenyan Zhao, Huan Hao, Huan Liu, Li Zhang, Lingling Nie, Haiyang Qin, Meng Wang, Qiong Lu, Xiaoyu Li, Qiyu Sun, Junkai Liu, Changfa Fan, Weijin Huang, Miao Xu, Youchun Wang   +17 more
doaj   +1 more source

The antigenicity of SARS-CoV-2 Delta variants aggregated 10 high-frequency mutations in RBD has not changed sufficiently to replace the current vaccine strain

Signal Transduction and Targeted Therapy, 2022
Emerging SARS-CoV-2 variants are the most serious problem for COVID-19 prophylaxis and treatment. To determine whether the SARS-CoV-2 vaccine strain should be updated following variant emergence like seasonal flu vaccine, the changed degree on ...
Jiajing Wu, Jianhui Nie, Li Zhang, Hao Song, Yimeng An, Ziteng Liang, Jing Yang, Ruxia Ding, Shuo Liu, Qianqian Li, Tao Li, Zhimin Cui, Mengyi Zhang, Peng He, Youchun Wang, Xiaowang Qu, Zhongyu Hu, Qihui Wang, Weijin Huang   +18 more
doaj   +1 more source

Nipah pseudovirus system enables evaluation of vaccines in vitro and in vivo using non-BSL-4 facilities

Emerging Microbes and Infections, 2019
Because of its high infectivity in humans and the lack of effective vaccines, Nipah virus is classified as a category C agent and handling has to be performed under biosafety level 4 conditions in non-endemic countries, which has hindered the development
Jianhui Nie, Lin Liu, Qing Wang, Ruifeng Chen, Tingting Ning, Qiang Liu, Weijin Huang, Youchun Wang   +7 more
doaj   +1 more source

Development of a Triple-Color Pseudovirion-Based Assay to Detect Neutralizing Antibodies against Human Papillomavirus

Viruses, 2016
Pseudovirion-based neutralization assay is considered the gold standard method for evaluating the immune response to human papillomavirus (HPV) vaccines.
Jianhui Nie, Yangyang Liu, Weijin Huang, Youchun Wang   +3 more
doaj   +1 more source

The rise of companies from emerging markets in global health governance: opportunities and challenges [PDF]

, 2014
The article analyses the involvement of pharmaceutical companies from emerging markets in global health governance. It finds that they play a central role as low-cost suppliers of medicines and vaccines and, increasingly, new technologies.
ANNE ROEMER-MAHLER, Brooks, Brown, Buse, Chaudhuri, Clarke, Cooper Ramo, Drezner, Elbe, Fleury, Gold, Knight, Levy, Meyer, Petryna, Ramamurti, Roemer-Mahler, Schoofs, Wells, Whyte, Williams, Williamson, Youde, Zimmerman   +23 more
core   +1 more source

Retrospective immunogenicity analysis of seasonal flu H3N2 vaccines recommended in the past ten years using immunized animal seraResearch in context

EBioMedicine, 2022
Summary: Background: Influenza A (H3N2) virus (A/H3N2) has complex antigenic evolution, resulting in frequent vaccine strain updates. We aimed to evaluate the protective effect of the vaccine strains on the circulating strains from past ten years and ...
Mengyi Zhang, Yimeng An, Xi Wu, Meina Cai, Xinyu Zhang, Chaoying Yang, Jincheng Tong, Zhimin Cui, Xueli Li, Weijin Huang, Chenyan Zhao, Youchun Wang   +11 more
doaj   +1 more source