Results 111 to 120 of about 67,377 (251)

Identification of a novel regulatory mechanism for the disease associated protein, uPAR [PDF]

, 2014
Expression quantitative trait loci (eQTLs), as determined through a series of statistical association studies collectively known as genome-wide association (GWA) studies, have provided us with a hypothesis free approach for the investigation into ...
Portelli, Michael A., Hall, Ian P., Sayers, Ian   +2 more
core  

Stratification of chronic rhinosinusitis with nasal polyps by distinct sinonasal microbial communities and their clinical and pathological correlations

iMetaOmics, EarlyView.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory condition. Dysbiosis is commonly observed. This study identified distinct sinonasal microbial communities in CRSwNP patients and explored their clinical and pathological associations. Two distinct microbial communities were identified: community type 1 (CT1), dominated by
Bixing Fang, Yanmin Liu, Qing Bao, Lin Sun, Hexin Chen, Qingxiang Meng, Linyi Jiao, Xiaoyan Ye, Jian Li, Tao Ding, Chunwei Li   +10 more
wiley   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Airway epithelium and asthma

, 2020
Asthma is a respiratory chronic inflammatory disease with well-established symptoms, but the pathophysiological mechanisms remain largely unexplored. In this thesis, we aim to analyse and clarify responses of asthmatic airway epithelial cells.In chapter 2, we showed that bronchial epithelium from mild asthma patients in response to in vivo RV16 ...
openaire   +2 more sources

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, EarlyView.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

A Novel Air‐Liquid Interface Exposure System for Continuous Gas Exposure of Airway Epithelial Cells: Exposure of NO2 With Viral Co‐Challenge

Journal of Applied Toxicology, EarlyView.
ABSTRACT Most in vitro toxicological research investigating the effects of inhaled compounds employ short‐term exposures of a couple of hours, or repeated, intermittent exposures for a limited number of days with exposure free periods, whereas in reality, we are continuously exposed, albeit to variable concentrations.
Marcia M. Oldenburger, Evert Duistermaat, Pieter S. Hiemstra, Flemming R. Cassee, Yvonne C. M. Staal   +4 more
wiley   +1 more source

Cellular Responses to Tartrazine and Sulfanilic Acid Exposure in BEAS‐2B Cells: Viability, Apoptosis, and DNA Damage

Journal of Applied Toxicology, EarlyView.
ABSTRACT Tartrazine is a synthetic azo dye widely used in food, pharmaceutical, and cosmetic products, resulting in extensive human exposure, while its toxicity and that of its primary metabolite, sulfanilic acid, remain controversial. Considering the reported association of tartrazine with hypersensitivity and allergic‐like reactions, human bronchial ...
Merve Baysal, Abdullah Burak Karaduman, Büşra Korkut Çelikateş, Merve Güven, Özlem Atlı‐Eklioğlu, Sinem Ilgın   +5 more
wiley   +1 more source

Ultrasonic Image Characteristics of Palatine Tonsils in Healthy Children and Analysis of Factors Influencing Image Quality

Journal of Clinical Ultrasound, Volume 53, Issue 3, Page 436-444, March/April 2025.
The ultrasound detection rate of the palatine tonsils in children was good. There are characteristic ultrasonic image manifestations. Tonsil ultrasound image quality is affected by individual and local factors. ABSTRACT Objective To explore the ultrasonic image characteristics of palatine tonsils in healthy children and the factors affecting image ...
Ying Cao, Lei Sun, XiaoPeng Li, Qi Zhang, Yue Gao, Hua Wang   +5 more
wiley   +1 more source

Airway epithelium in obliterative airway disease

, 2005
Lung transplantation is currently the only available treatment for endstage lung disease patients. Despite the success of improved modern lung transplantation with the introduction of new surgical techniques, improved immunosuppressive agents and innovations in managing of acute rejection and infection, the survival rate of recipients is 75% at 1 year ...
openaire   +1 more source