Results 121 to 130 of about 67,377 (251)

PDCD5 Contributes to Airway Epithelial Cell Damage via Mitochondrial Pathway and Participates in COPD Pathogenesis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Airway epithelial injury plays a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction is implicated in this injury, while the underlying mechanism remains incompletely understood. RNA sequencing was conducted to identify key genes involved in mitochondrial dysfunction in airway epithelial
Hu Shan, Rui Zhang, Yu‐er Li, Rui Li, Shao‐bo Ge, Jin Liu, Shi‐yuan Yao, Xia Yang, Tao Zhang, Ming Zhang   +9 more
wiley   +1 more source

Recurrent Respiratory Papillomatosis Foundation Position Statement on the Management of Adults With RRP

The Laryngoscope, EarlyView.
ABSTRACT Objective With regulatory approval of HPV‐specific immunotherapy for recurrent respiratory papillomatosis (RRP) and growing experience with systemic bevacizumab, a management algorithm incorporating these medical treatments is warranted. Data Sources and Methods RRP Foundation (RRPF) Key Opinion Leaders offer a proposed management algorithm ...
Simon R. Best, Aaron D. Friedman, Clark A. Rosen, Robert T. Sataloff, Laura A. Matrka, H. Steven Sims, David E. Rosow, Nabil F. Saba, David G. Lott, Adam M. Klein, Ted Mau, Milan R. Amin, Kathryn A. Wikenheiser‐Brokamp, Scott M. Norberg, Kim McClellan, Geoffrey D. Young, Clint T. Allen, on behalf of the Recurrent Respiratory Papillomatosis Foundation   +17 more
wiley   +1 more source

Socioeconomic Deprivation and Vocal Handicap in Adults With Voice Disorders

The Laryngoscope, EarlyView.
This study examined the relationship between socioeconomic deprivation and quality of life as measured by the Voice Handicap Index (VHI) in adults with voice disorders. Patients living with socioeconomic deprivation experienced greater voice‐related handicap from voice disorders than those from more affluent backgrounds, even when controlling for ...
Robert Brinton Fujiki, Susan L. Thibeault   +1 more
wiley   +1 more source

The Laryngeal Auditory Startle Reflex (LASR): A New Component of the Auditory Startle Response

The Laryngoscope, EarlyView.
The auditory startle reflex contains a distinct laryngeal component, termed the laryngeal auditory startle reflex (LASR). In healthy adults, the LASR is modulated by supratentorial influences and habituates to repetitive stimuli. Physiologic and pathologic implications for the LASR as a component of the overall human SR remain to be determined but may ...
Catherine F. Sinclair, Maria J. Tellez, Paola M. Rodriguez Morel, Patricia Torralba, Sedat Ulkatan   +4 more
wiley   +1 more source

Bronchial Mucosal Abnormalities in Idiopathic Subglottic Stenosis

The Laryngoscope, EarlyView.
Idiopathic subglottic stenosis (iSGS) is a challenging variant of airway stenosis associated with consistent distal airway abnormalities on bronchoscopy, including pits, depressions, and striations. Despite these findings, most patients demonstrate normal or mild–moderate obstruction on spirometry.
Sydney Ring, Andrew Jay Bowen, Tessa Griffin, J. Scott Ferguson, Seth H. Dailey   +4 more
wiley   +1 more source

Endothelial Hydrogels Improve Microvascular Regeneration and Perfusion in Tracheal Scaffolds

The Laryngoscope, EarlyView.
Insufficient vascularization remains a major barrier to successful tracheal transplantation. This study demonstrates that an endothelial hydrogel significantly enhances graft perfusion and neovessel organization compared to non‐endothelial hydrogel controls.
Molly O. Hunter, Lumei Liu, Nathaniel Hochuli, Olivia Chan, Jazmin Calyeca, Ada C. Sher, Tendy Chiang   +6 more
wiley   +1 more source

A Comprehensive Review of the Genetic Etiology and Management of Orofacial Clefts

Pediatric Discovery, EarlyView.
ABSTRACT Cleft lip (CL) and cleft palate (CP), collectively referred to as orofacial clefts (OFCs), are among the most common birth defects and can have significant effects on speech, nutrition, and physical and psychosocial development. Manifestation, classification, and treatment plans of OFCs are diverse and not standardized.
Emily Kim, Rebeka Dejenie, Caroline Kim, Russell Reid   +3 more
wiley   +1 more source

The Airway Epithelial Barrier in Childhood Asthma: A Central Player in Glucocorticoid Therapy, Resistance, and Severe Asthma

Pediatric Discovery, EarlyView.
ABSTRACT Childhood asthma remains a global public health challenge with suboptimal control, despite the availability of inhaled corticosteroids (ICS) as first‐line therapy. Glucocorticoids suppress inflammation and protect the airway epithelial barrier (AEB) via genomic and nongenomic pathways.
Tangqiaochu Gan, Zhou Fu, Chao Niu
wiley   +1 more source

Anti‐Allergic Potential of Chamaecrista nomame and Its Compound Luteolin for Novel Asthma Therapy

Phytotherapy Research, EarlyView.
Chamaecrista nomame (CN) and its active compound luteolin attenuate allergic airway inflammation by inhibiting mast cell activation and suppressing NF‐κB/MAPK signaling, leading to reduced cytokine production and OVA‐specific IgE levels. ABSTRACT Asthma is a chronic inflammatory disease driven by dysregulated immune responses and mast cell activation ...
Tae Kyeom Kang, Myungsuk Kim, Tam Thi Le, Geon Park, Yuna Jung, Hyobin Jeong, Youngsang Yoo, Wook‐Bin Lee, Sang Hoon Jung   +8 more
wiley   +1 more source

Infant fecal microbiome dysbiosis varies by feeding type in setting of severe bronchiolitis

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Theresa C. Barrett, Qi Zheng, Bronchiolitis Microbiome Research Group, Amy Thompson, Matthew D. Di Guglielmo, Zugui Zhang, Deepti Anand, Claire Loiselle, Talia Gillespie, Mackenzie Seymour   +9 more
wiley   +1 more source