Results 141 to 150 of about 375,726 (199)
Effect of Notch1 on Vocal Fold Re‐Epithelization After Acute Injury
The Laryngoscope, EarlyView.Conditional deletion of Notch1 in Lrig1‐expressing vocal fold epithelial cells impaired re‐epithelialization following naphthalene injury, resulting in sustained basal cell proliferation, abnormal epithelial differentiation, and prolonged inflammatory cell infiltration.
Jie Cai +2 more
wiley +1 more source
Evaluating the Local Response of a Novel Injectable Capsule for Drug Delivery in the Trachea
The Laryngoscope, EarlyView.A novel PLGA polymer capsule was developed for localized pretracheal drug delivery and evaluated for short‐term local tissue safety in a rabbit model. Implant placement was confirmed by ultrasound and was well tolerated over 14 days, with preservation of airway patency, native tracheal architecture, and biomechanical properties.
Denzel Ryan D. Cruz +7 more
wiley +1 more source
Occupational HPV Exposure in Otolaryngology: A Scoping Review of Detection, Risk, and Prevention
The Laryngoscope, EarlyView.This scoping review identified 10 studies evaluating occupational HPV exposure in otolaryngology. HPV DNA was detected in surgical plume following some HPV‐related procedures, including up to 56.7% of CO2 laser plume samples, while the only study assessing oral HPV among exposed clinicians reported a prevalence of 2.2%, not exceeding that of the ...
Ying Jie Li +2 more
wiley +1 more source
Therapeutic JAK Inhibition in Idiopathic Subglottic Stenosis
The Laryngoscope, EarlyView.Three patients with idiopathic subglottic stenosis and rheumatoid arthritis began JAK inhibitor therapy, after which the mean surgical‐free interval between endoscopic dilations rose from 317 to 631 days and the annualized dilation rate fell from 1.24 to 0.38 per patient‐year. Figure 2 shows this as a per‐patient timeline.
Riley M. Larkin +5 more
wiley +1 more source
Free Mucosal Grafting Is a Simple Adjunct for Rapid Re‐Epithelization in Septal Perforation Repair
The Laryngoscope, EarlyView.In septal perforation repair, a free mucosal graft placed on the contralateral septum to the pedicled mucosal flap can resurface an area vulnerable to crusting and poor healing. Among 90 patients, 92.6% of grafts integrated completely when the perforation was successfully closed and complete perforation closure was the only independent predictor of ...
Nicholas J. Campion +13 more
wiley +1 more source
Reinke's Edema: From the Operating Theater to Office‐Based Blue Laser Treatment
The Laryngoscope, EarlyView.In this retrospective study, 52 patients with Reinke's edema treated with office‐based 445‐nm blue laser were compared with a historical cohort of 40 patients treated by microlaryngoscopy under general anesthesia. Office‐based treatment was associated with significant improvement in Voice Handicap Index‐10 scores (15.0–2.0; p < 0.001) and complete ...
Francesco Mora +5 more
wiley +1 more source
Med Research, EarlyView.This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng +14 more
wiley +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered “undruggable” by conventional inhibition‐based approaches. Aptamer–based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural ...
Ambrin Malik +3 more
wiley +1 more source
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract Objective Olfactory function is influenced by nasal airflow dynamics and anatomical variations within the nasal cavity. This narrative review evaluates how nasal anatomy and airflow relate to olfactory outcomes, with a particular focus on olfactory changes following functional nasal surgery. Data Sources PubMed.
Joshua Ferreira +3 more
wiley +1 more source
Pediatric Discovery, EarlyView.Mechanism underlying the negative effects of glucocorticoids on the airway epithelial barrier. Glucocorticoids upregulate autophagy factors and downregulate anti‐autophagy factors. Enhanced autophagy promotes excessive apoptosis and epithelial detachment, impairing airway barrier function.
Hao You +10 more
wiley +1 more source