ABSTRACT Objective With regulatory approval of HPV‐specific immunotherapy for recurrent respiratory papillomatosis (RRP) and growing experience with systemic bevacizumab, a management algorithm incorporating these medical treatments is warranted. Data Sources and Methods RRP Foundation (RRPF) Key Opinion Leaders offer a proposed management algorithm ...
Simon R. Best +17 more
wiley +1 more source
HLA-DRA-mediated inhibition of T-Cell proliferation by differentiated airway epithelium and its disruption in smoking-associated airway inflammation. [PDF]
Zeng J +5 more
europepmc +1 more source
Endothelial Hydrogels Improve Microvascular Regeneration and Perfusion in Tracheal Scaffolds
Insufficient vascularization remains a major barrier to successful tracheal transplantation. This study demonstrates that an endothelial hydrogel significantly enhances graft perfusion and neovessel organization compared to non‐endothelial hydrogel controls.
Molly O. Hunter +6 more
wiley +1 more source
Interkingdom signaling elicited by bacterial extracellular vesicles in human cystic fibrosis airway epithelium and neutrophils. [PDF]
Lakkappa N +14 more
europepmc +1 more source
Superior Labial Artery Flap for Septal Perforation Repair: The Boxer's Flap
The nasal floor flap, or Boxer's flap, is an anteriorly pedicled, superior labial artery–based mucosal flap that provides excellent closure rates in septal perforation repair when traditional septal flaps are not feasible. The schematic shows: (A) preoperative perforation, (B) nasal floor flap elevation (with the pedicle maintained at the inferior ...
Nicholas J. Campion +5 more
wiley +1 more source
Verteporfin, an inhibitor of nuclear YAP, improved multi-ciliated cell differentiation in the airway epithelium. [PDF]
Nakamura R +6 more
europepmc +1 more source
Effects of Intubation Duration on Trachea: A Histopathological Study
This study evaluated the histopathological effects of prolonged endotracheal intubation on the human trachea using biopsy specimens obtained during tracheotomy. Prolonged intubation was associated with progressive inflammatory and structural changes, with tracheal dilatation and perichondritis increasing significantly after 14 days.
Osman Kilic +6 more
wiley +1 more source
Transcriptomic and functional responses of the cystic fibrosis airway epithelium to CFTR modulator therapy. [PDF]
Vladar EK +15 more
europepmc +1 more source
Effect of Notch1 on Vocal Fold Re‐Epithelization After Acute Injury
Conditional deletion of Notch1 in Lrig1‐expressing vocal fold epithelial cells impaired re‐epithelialization following naphthalene injury, resulting in sustained basal cell proliferation, abnormal epithelial differentiation, and prolonged inflammatory cell infiltration.
Jie Cai +2 more
wiley +1 more source
<i>Klebsiella pneumoniae</i> infection induces an S100A8/A9-mediated autocrine loop in human airway epithelium to amplify inflammation. [PDF]
Zheng J +5 more
europepmc +1 more source

