Results 31 to 40 of about 60,557 (265)

Barrier function of airway tract epithelium [PDF]

Tissue Barriers, 2013
Airway epithelium contributes significantly to the barrier function of airway tract. Mucociliary escalator, intercellular apical junctional complexes which regulate paracellular permeability and antimicrobial peptides secreted by the airway epithelial cells are the three primary components of barrier function of airway tract. These three components act
Ganesan, Shyamala, Comstock, Adam T, Sajjan, Uma S   +2 more
openaire   +2 more sources

Mechanically patterning the embryonic airway epithelium [PDF]

Proceedings of the National Academy of Sciences, 2015
SignificanceDuring branching morphogenesis of the developing lung, it is generally thought that a spatial template of biochemical cues determines the airway branching pattern. Here, however, we demonstrate that physical mechanisms can control the pattern of airway branching.
Victor D, Varner, Jason P, Gleghorn, Erin, Miller, Derek C, Radisky, Celeste M, Nelson   +4 more
openaire   +2 more sources

The Dual Role of the Airway Epithelium in Asthma: Active Barrier and Regulator of Inflammation

Cells, 2023
Chronic airway inflammation is the cornerstone on which bronchial asthma arises, and in turn, chronic inflammation arises from a complex interplay between environmental factors such as allergens and pathogens and immune cells as well as structural cells ...
Andreas Frey, Lars P. Lunding, Michael Wegmann   +2 more
doaj   +1 more source

Expression of ICAM-1 on human bronchial epithelial cells after influenza virus infection

Allergology International, 1996
Damage of bronchial epithelium is a feature of airway viral infection and airway inflammatory disease, such as bronchial asthma. Adhesion molecules, which are expressed on bronchial epithelium, play an important role in the pathogenesis of epithelial ...
Satoshi Matsukura, Fumio Kokubu, Hiromichi Noda, Hiroyuki Watanabe, Kunihiko Fukuchi, Kunio Gomi, Mitsuru Adachi   +6 more
doaj   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Paracrine signaling of ferroptotic airway epithelium in crystalline silica-induced pulmonary fibrosis augments local fibroblast activation through glycolysis reprogramming

Ecotoxicology and Environmental Safety
Chronic exposure to crystalline silica (CS) contributes to pulmonary fibrosis. Airway epithelium dysfunction and fibroblast activation have both been recognized as pivotal players, alongside disturbances in ferroptosis and glycolysis reprogramming ...
Qianmin Li, Yi Ling, Yu Ma, Tao Zhang, Youjing Yang, Shasha Tao   +5 more
doaj   +1 more source

In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis in mouse. [PDF]

PLoS ONE, 2010
BACKGROUND: TGF-beta has been postulated to play an important role in the maintenance of epithelial homeostasis and the development of epithelium-derived cancers.
Xiaolin Luo, Qiurong Ding, Min Wang, Zhigang Li, Kairui Mao, Bing Sun, Yi Pan, Zhenzhen Wang, Ying Qin Zang, Yan Chen   +9 more
doaj   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Expression Pattern of the SARS-CoV-2 Entry Genes ACE2 and TMPRSS2 in the Respiratory Tract

Viruses, 2020
To address the expression pattern of the SARS-CoV-2 receptor ACE2 and the viral priming protease TMPRSS2 in the respiratory tract, this study investigated RNA sequencing transcriptome profiling of samples of airway and oral mucosa.
Yichuan Liu, Hui-Qi Qu, Jingchun Qu, Lifeng Tian, Hakon Hakonarson   +4 more
doaj   +1 more source

Airway Epithelium Stimulates Smooth Muscle Proliferation [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2009
Communication between the airway epithelium and stroma is evident during embryogenesis, and both epithelial shedding and increased smooth muscle proliferation are features of airway remodeling. Hence, we hypothesized that after injury the airway epithelium could modulate airway smooth muscle proliferation.
Malavia, Nikita K, Raub, Christopher B, Mahon, Sari B, Brenner, Matthew, Panettieri, Reynold A, George, Steven C   +5 more
openaire   +4 more sources