Results 1 to 10 of about 77,217 (181)

Airway Remodeling in Asthma [PDF]

Frontiers in Medicine, 2020
Asthma is an inflammatory disease of the airways that may result from exposure to allergens or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of breath.
Kenneth P. Hough, Miranda L. Curtiss, Trevor J. Blain, Rui-Ming Liu, Jennifer Trevor, Jessy S. Deshane, Victor J. Thannickal   +6 more
doaj   +3 more sources

Airway remodeling in chronic obstructive pulmonary disease: characteristics and opportunities [PDF]

Frontiers in Medicine
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by irreversible airway remodeling and is a global burden on the healthcare system.
Minjie Pan, Xiaojing Zhou
doaj   +2 more sources

Airway Remodeling in Asthma

Allergology International, 2007
Airway remodeling can be defined as changes in the composition, content, and organization of the cellular and molecular constituents of the airway wall.
Yuki Sumi, Qutayba Hamid
doaj   +3 more sources

IFITM1 is required for epithelial mesenchymal transition in airway remodeling of allergic asthma [PDF]

World Allergy Organization Journal
Background: Interferon-induced transmembrane protein 1 (IFITM1) restricts virus infection. IFITM proteins are involved in Th2 cell differentiation in allergic asthma. The epithelial‒mesenchymal transition (EMT) regulates allergic airway remodeling.
Manni Zhu, MD, Xiaoqin Weng, MD, Chuanli Zhang, MD, Xiaofei Song, MD, Shan Liu, MD, Tingting Xu, MD, Zhengxia Wang, MD, Zhongqi Chen, MD, Mingshun Zhang, MD, Mao Huang, MD, Ningfei Ji, MD   +10 more
doaj   +2 more sources

Increased expression of cathepsin C in airway epithelia exacerbates airway remodeling in asthma [PDF]

JCI Insight
Airway remodeling is a critical factor determining the pathogenesis and treatment sensitivity of severe asthma (SA) or uncontrolled asthma (UA). The activation of epithelial-mesenchymal trophic units (EMTUs) regulated by airway epithelial cells (AECs ...
Lin Yuan, Qingwu Qin, Ye Yao, Long Chen, Huijun Liu, Xizi Du, Ming Ji, Xinyu Wu, Weijie Wang, Qiuyan Qin, Yang Xiang, Bei Qing, Xiangping Qu, Ming Yang, Xiaoqun Qin, Zhenkun Xia, Chi Liu   +16 more
doaj   +2 more sources

Research trends on airway remodeling: A bibliometrics analysis [PDF]

Heliyon
Background: Airway remodeling is an essential pathological basis of respiratory diseases such as asthma and COPD, which is significantly related to pulmonary function and clinical symptoms.
Pengcheng Liu, Yu Wang, Chen Chen, Hui Liu, Jing Ye, Xiaoming Zhang, Changxiu Ma, Dahai Zhao   +7 more
doaj   +2 more sources

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα [PDF]

Advanced Science
Asthma is a prevalent chronic airway disorder characterized by airway hyperresponsiveness (AHR), persistent airway inflammation, and airway remodeling.
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
doaj   +2 more sources

Drugs Used in the Treatment of Viral Infections for the Prevention of Airway Remodeling in Asthma [PDF]

Mediators of Inflammation
One of the main causes of the exacerbation of chronic airway inflammatory diseases is respiratory virus infections. The most prevalent viruses that can infect humans multiple times a year are rhinovirus (RV) and respiratory syncytial virus (RSV). Because
Joanna Wieczfinska, Rafal Pawliczak
doaj   +2 more sources

Airway Remodeling and Airway Smooth Muscle in Asthma

Allergology International, 2006
Airway remodeling in asthma has been recognized as structural changes of airways such as smooth muscle hypertrophy (an increase in size of airway smooth muscle cells) and hyperplasia (an increase in the number of airway smooth muscle cells), thickening ...
Mitsuru Munakata
doaj   +3 more sources

IFN-γ and TNF-α synergize to inhibit CTGF expression in human lung endothelial cells. [PDF]

, 2012
Connective tissue growth factor (CTGF/CCN2) is an angiogenetic and profibrotic factor, acting downstream of TGF-β, involved in both airway- and vascular remodeling.
Fehrholz, Markus, Kramer, Boris W., Krump-Konvalinkova, Vera, Kunzmann, Steffen, Laug, Roderich, Schütze, Norbert, Speer, Christian P.   +6 more
core   +19 more sources