Results 181 to 190 of about 397,469 (244)

Targeting CD30L Alleviates Airway Remodeling via JNK/p38 MAPK Pathway in OVA-Induced Asthmatic Mice. [PDF]

Allergy Asthma Immunol Res
Xu C, Liu X, Zeng R, Zhang J, Pan Y, Qiao C, Wang P, Shi S, Wang Y, Liu X, Qi Q, Gao M, Zhi L, Dong X, Fei J, Dong L.   +15 more
europepmc   +1 more source

Mepolizumab Modifies Blood Eosinophil Proteome and Transcriptome in Severe Eosinophilic Asthma

Allergy, EarlyView.
This study investigates the effect of mepolizumab on the proteomic and transcriptomic profile of blood eosinophils in SEA patients. Mepolizumab reduces the migratory capacity and effector‐related molecular signatures of circulating eosinophils in SEA patients.
Pablo Miguéns‐Suárez, Sara Vázquez‐Mera, Laura Martelo‐Vidal, Marina Blanco Aparicio, Uxío Calvo Álvarez, Coral González Fernández, Mar Mosteiro Añón, Dolores Corbacho Abelaira, Tamara Hermida Valverde, Christian Calvo Henríquez, Susana B. Bravo, Lena Uller, Juan J. Nieto‐Fontarigo, Francisco J. Salgado, Francisco J. González‐Barcala   +14 more
wiley   +1 more source

The Role of Aryl Hydrocarbon Receptor in Airway Remodeling: Mechanistic Insights Across Cellular Functions. [PDF]

Clin Rev Allergy Immunol
Reza MI, Kumar A, Britt RD, Sathish V.
europepmc   +1 more source

Tuft cells shape airway remodeling by eliciting OXGR1- and SOX9-dependent stem cell programs. [PDF]

Nat Commun
Lee M, Wang X, Ye Q, Huang GX, Mandanas MV, Hallen NR, Cho L, Boyce JA, Laidlaw TM, Barrett NA.   +9 more
europepmc   +1 more source

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

Rhizoma Dioscoreae Nipponicae attenuates airway remodeling and angiogenesis-related changes in asthma with altered mTOR/4EBP1/HIF-1α/VEGF pathway markers. [PDF]

World Allergy Organ J
Zhou X, Wang Z, Zheng S.
europepmc   +1 more source

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

CCN1 drives asthmatic airway remodeling through amplification of TGF-β1/Smad3 signaling. [PDF]

Respir Res
Wang Y, Xu C, Zeng R, Liu X, Zhang J, Pan Y, Qi Q, Qiao C, Shi S, Wang P, Liu X, Gao M, Gao T, Dong L.   +13 more
europepmc   +1 more source

Nematode in Cockroaches: A Potential Allergen Source

Allergy, EarlyView.
Dongjun Kang, Myung‐hee Yi, Jun Ho Choi, Yun Soo Jang, Seongjun Choe, Ju Yeong Kim   +5 more
wiley   +1 more source

Environmental Changes and Their Effect on the Airway Microbiome: Implications for Airway Diseases

Allergy, EarlyView.
ABSTRACT Obstructive airway diseases, including asthma and chronic obstructive pulmonary disease (COPD), represent the two major chronic airway inflammatory diseases. In both conditions, the airways are exposed to a variety of microbial and environmental stimuli.
Georgios Rentzos, Evangelia Fouka, Nikolaos Lazarinis, Theo Gülen, Patricia Ramos‐Ramirez, Lauren Flynn, Stelios Loukides, Paraskevi Xepapadaki, Nikolaos G. Papadopoulos, Anders Lindén, Apostolos Bossios   +10 more
wiley   +1 more source