Results 191 to 200 of about 397,469 (244)

Circulating Cell-Free RNA Reflects Immune-Associated and Airway Remodeling Signatures in Equine Asthma. [PDF]

J Immunol Res
Zhang B, Agdour H, Riihimäki M, Hansen S, Raine A.   +4 more
europepmc   +1 more source

Adenosine—A Regulator of Human Testicular Peritubular Cells

Andrology, EarlyView.
ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz, Annika Liebich, Youli Stepanov, Jan B. Stöckl, Mirko Peitzsch, Michaela Schneider, Julia Schneider, Nicole Kreitmair, Matthias Trottmann, Frank‐Michael Köhn, Jovica Ninkovic, Thomas Fröhlich, Artur Mayerhofer   +12 more
wiley   +1 more source

Dupilumab attenuate IL-4 and IL-13 synergistic effect on airway remodeling in asthma via blocking IL-4Rα/STAT6 axis. [PDF]

Sci Rep
Sahnoon L, Abujabal R, Alanta TM, Mdkhana B, Olivenstein R, Puré E, Mahboub B, Laumonnier Y, Hamoudi R, Bajbouj K, Hamid Q.   +10 more
europepmc   +1 more source

Systematic Review and Meta‐Analysis Suggested That Neutrophils Predominated the Airways of Children With the Respiratory Syncytial Virus

Acta Paediatrica, EarlyView.
ABSTRACT Aim The respiratory syncytial virus (RSV) is a predominant aetiology of early‐life respiratory infections. This systematic review and meta‐analysis compared the cell types involved in airways inflammation in children with and without RSV, noting that immune responses can influence long‐term complications and may involve different inflammatory ...
Muhammad Pradhika Mapindra, Naz Chughtai, Muhammad Pradhiki Mahindra, Paul McNamara, Cissy Kartasasmita, Malcolm Gracie Semple, Mahendra Tri Arif Sampurna, Howard Clark, Jens Madsen   +8 more
wiley   +1 more source

IL-36 participated in airway remodeling in chronic asthma model by inducing epithelial-mesenchymal transition process. [PDF]

Eur J Med Res
Zhang M, Cen J, Gan W, Feng K, Yang H, Zou X, Li H, Zhang T.   +7 more
europepmc   +1 more source

Metabolic remodelling in anthracycline cardiotoxicity: mechanisms and therapeutic insights

British Journal of Pharmacology, EarlyView.
Cardiac metabolic remodelling in anthracycline‐induced cardiomyopathy and metabolically oriented cardioprotective strategies. Schematic representation of substrate utilization, mitochondrial bioenergetic function and metabolic flexibility in the healthy heart, in anthracycline‐induced cardiomyopathy and under potential cardioprotective interventions ...
Giulia Guerra, Francesco Niro, Marco Mergiotti, Giovanni Gavatorta, Emilio Hirsch, Alessandra Ghigo   +5 more
wiley   +1 more source

Correction: Zeng et al. Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling. <i>Cells</i> 2022, <i>11</i>, 1774. [PDF]

Cells
Zeng LH, Barkat MQ, Syed SK, Shah S, Abbas G, Xu C, Mahdy A, Hussain N, Hussain L, Majeed A, Khan KU, Wu X, Hussain M.   +12 more
europepmc   +1 more source

Inhibition of the MER tyrosine kinase ameliorates pulmonary fibrosis by suppressing macrophage M2 polarisation and osteopontin signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose The MER proto‐oncogene tyrosine kinase (MERTK) has been implicated in the pathogenesis of pulmonary fibrosis (PF), and MERTK inhibition has been shown to ameliorate PF. However, the mechanisms remain unclear. Here, we have investigated how MERTK inhibition attenuates bleomycin (BLM)‐induced PF in mice and to elucidate the ...
Juan Li, Xiangsheng Yang, Xiao Xiao Tang
wiley   +1 more source

Tezepelumab in severe asthma: chest computed tomography assessment of airway remodeling and clinical remission. [PDF]

Front Pharmacol
Lupia C, Battaglia C, Pastore D, Lee Y, Piazzetta GL, Chiarella E, Lobello N, Sireno G, Pullano A, Crimi C, Vatrella A, Manti F, Arcuri PP, Laganà D, Pelaia G, Pelaia C.   +15 more
europepmc   +1 more source

A Transgenic Rat Model of DXd ADC‐Related Interstitial Pneumonitis for Mechanistic and Translational Research

Cancer Science, EarlyView.
hTROP2 Tg rats exhibit key pathological and transcriptomic features of DXd ADC‐related ILD, supporting their utility as a translational model. Rat, alveolus, antibody illustrations were adapted from NIAID NIH BioArt Source. ABSTRACT Deruxtecan‐based antibody‐drug conjugates (DXd ADCs) provide substantial clinical benefit across multiple malignancies ...
Kazuyoshi Kumagai, Yuma Nagai, Yuji Shirai, Kazunori Fujimoto, Masako Imaoka, Katsuyoshi Chiba   +5 more
wiley   +1 more source