Results 211 to 220 of about 365,854 (289)

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell‐State Plasticity in the CFTR Modulator Era

Cell Proliferation, EarlyView.
In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Bala Umashankar, Ines Pankonien, Margarida Amaral, Chee Y. Ooi, Thierry Jardé, Shafagh A. Waters   +5 more
wiley   +1 more source

Pharmacological Gq targeting prevents asthmatic airway remodeling. [PDF]

Mol Ther
Dietrich JM, Matthey M, Simon A, Seidinger A, Koziol-White C, Panettieri RA, Fleischmann BK, Wenzel D.   +7 more
europepmc   +1 more source

Human iPSC‐Derived Vascularised Lung Organoids for Modelling COPD and Pulmonary Hypertension

Cell Proliferation, EarlyView.
Vascularised lung organoids (vLOs) that faithfully mimic human lung tissue architecture and disease pathology are critical for advancing pulmonary research but remain challenging to generate. Here, we developed a robust self‐organisation protocol to produce vLOs with cellular heterogeneity and functional vasculature. The engineered blood vessels within
Simin Jiang, Liangliang Tian, Jingge Qu, Yi Hong, Dian Chen, Zihang Pan, Huanyu Long, Lanhe Chu, Weijing Kong, Qiyang Yao, Xiaojing Ma, Yun Zhao, Baihui Ma, Kai Wang, Yahong Chen   +14 more
wiley   +1 more source

Mesenchymal stem cell-derived exosomes: a new hope for improving asthma airway remodeling. [PDF]

Ann Med
Suo R, Hao T, Wumaier R, Zhao J, Du X, Suo Y, Zhao X.   +6 more
europepmc   +1 more source

AIRWAY REMODELING

Japanese Journal of Allergology, 2000
openaire   +1 more source

Eosinophilia and Hypereosinophilia: A Practical Approach to Navigating a Broad Differential Diagnosis

European Journal of Haematology, EarlyView.
ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley   +1 more source

Smad7 ameliorate small airway remodeling in COPD by modulating epithelial-mesenchymal transition. [PDF]

Tob Induc Dis
Liu X, Sun S, He S, Xie L.
europepmc   +1 more source

Computed tomographic diagnosis and treatment of pneumolabyrinth in a mare with temporohyoid osteoarthropathy

Equine Veterinary Education, EarlyView.
Summary Pneumolabyrinth, which is the presence of gas within the labyrinth of the inner ear, can be associated with severe peripheral vestibular signs. This report describes a case of pneumolabyrinth in a horse that presented with vestibular ataxia. An 8‐year‐old Quarter Horse mare that presented with cranial nerve VII deficits underwent a standing ...
C. A. Jamieson, J. Jarvis, O. Nagasaka, M. Murakami, C. V. Fulkerson, A. C. B. C. F. Pinto   +5 more
wiley   +1 more source

Streptococcus equi subsp. equi infection causing temporomandibular septic arthritis treated by mandibular condylectomy in a horse

Equine Veterinary Education, EarlyView.
Summary A 26‐year‐old pony mare was referred for weight loss, dysphagia, lethargy and fever. Clinical examination revealed left temporal swelling, masseter muscle atrophy and malocclusion. Computed tomography examination showed severe temporomandibular joint (TMJ) alteration, extensive osteolysis of the mandibular condyle and temporal bone and ...
L. Gross, A. Charbonnel, A. Meurice, C. De Fourmestraux   +3 more
wiley   +1 more source

IL-17A activates the PI3K/AKT/mTOR pathway to regulate bronchial fibroblast autophagy-mediated airway remodeling: evidence from conditional IL-17RA-deficient mice. [PDF]

Front Physiol
Liu Y, Zhou J, An X, Gu Y, Zhang L, Ma Y, Tang Q, Yu S, Ouyang Y.   +8 more
europepmc   +1 more source