Results 211 to 220 of about 397,469 (244)

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

IL-17A activates the PI3K/AKT/mTOR pathway to regulate bronchial fibroblast autophagy-mediated airway remodeling: evidence from conditional IL-17RA-deficient mice. [PDF]

Front Physiol
Liu Y, Zhou J, An X, Gu Y, Zhang L, Ma Y, Tang Q, Yu S, Ouyang Y.   +8 more
europepmc   +1 more source

The Role of Innate Lymphoid Cells in Autoimmune, Allergic and Infectious Diseases: A Systematic Review

Immunology, EarlyView.
This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann, Henrique R. Dal‐Pizzol, Louise M. Lückmann, Davi E. Salini, Bruna C. Hasckel, Mikaeli Minati, Bruno Kluwe‐Schiavon, Tatiana Barichello   +7 more
wiley   +1 more source

Reduced Mitochondrial Adenine Nucleotide Translocase 1 (ANT1) Correlates With Aging-Associated Airway Remodeling. [PDF]

Aging Cell
Jha R, Shi J, Sedgwick MJ, Sui J, Corcoran TE, Kliment CR.   +5 more
europepmc   +1 more source

Wiskott–Aldrich Syndrome Protein Is Required for Glucocorticoid‐Dependent Eosinopoiesis and Eosinophil‐Rich Inflammation in Murine Models

Immunology, EarlyView.
WASP links GC‐dependent bone marrow eosinopoiesis to eosinophil‐rich allergic lung inflammation. GC‐responsive WASP+ stromal niche drives eosinopoiesis, generating eosinophilic lung inflammation and airway hyperresponsiveness. In WASP‐deficient allergic asthma, GC production and airway hyperresponsiveness are preserved, but GC‐driven bone marrow ...
Bruno Marques Vieira, Lucas Everton Simões, Pedro Xavier‐Elsas, Maria Ignez Capella Gaspar‐Elsas   +3 more
wiley   +1 more source

Evaluation of Small Airways Dysfunction With Dupilumab Using Airway Oscillometry in Uncontrolled Severe Asthma

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 264-266, March 2025.
Kirsten E. Stewart, Chris RuiWen Kuo, Rory Chan, Brian J. Lipworth   +3 more
wiley   +1 more source

Assessing mature and immature collagen in tonsillar tissue using second harmonic generation microscopy

Journal of Microscopy, EarlyView.
Abstract Recurrent tonsillitis (RT) and obstructive sleep apnoea (OSA) are major indications for tonsillectomy, yet their tissue‐level pathology remains unclear. Recurrent inflammation in RT may induce collagen remodelling through excess extracellular matrix deposition.
Kay Polland, Megan Clapperton, Thushitha Kunanandam, Catalina D Florea, Catriona M Douglas, Gail McConnell   +5 more
wiley   +1 more source

Pathogenic Cell in COPD: Mechanisms of Airway Remodeling, Immune Dysregulation, and Therapeutic Implications. [PDF]

Int J Chron Obstruct Pulmon Dis
Zhou K, Wen Q, Zuo Y, Bai G, Sun R.
europepmc   +1 more source

Obesity Modifies Sphingolipid Signatures in Childhood Asthma

Clinical &Experimental Allergy, EarlyView.
Harshita Shailesh, Alaa Abdelhamid, Ahmed Arabi, Yaman Al‐Haneedi, Shana Jacob, Giridhara Rathnaiah Babu, Stefan Worgall, Ibrahim Janahi   +7 more
wiley   +1 more source

NLBK alleviates airway remodeling in COPD by inhibiting RXRA-mediated transcription of PLA2G2A. [PDF]

Am J Transl Res
Zhang T, Fang F, Wu D, Wang G.
europepmc   +1 more source