Results 221 to 230 of about 365,854 (289)

Evaluation of Small Airways Dysfunction With Dupilumab Using Airway Oscillometry in Uncontrolled Severe Asthma

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 264-266, March 2025.
Kirsten E. Stewart, Chris RuiWen Kuo, Rory Chan, Brian J. Lipworth   +3 more
wiley   +1 more source

Hypercapnia Induces Mitochondrial Adaptations and Alters Glutamine Metabolism to Drive a Distinct Metabolic Phenotype in Monocytes

Immunology &Cell Biology, EarlyView.
Elevated CO2 (hypercapnia) is a feature of serious lung diseases, for example COPD and contributes to poor patient prognosis through modulation of immune cell function. Here we employ state‐of‐the art metabolomic and isotope tracing approaches to reveal CO2‐dependent mitochondrial alterations linked to suppressed ATP, proline and glutamate levels in ...
Ben Reddan, David E. Phelan, Xiaofei Yin, Lorraine Brennan, Martina Wallace, Eoin P. Cummins   +5 more
wiley   +1 more source

Asthma Incidence and Risk Factors in Tuberculosis Survivors: A Longitudinal Analysis of National Health Data

Clinical &Experimental Allergy, EarlyView.
Jong Geol Jang, Kyu Na Lee, Kyungdo Han, Ho Joo Yoon, Sang‐Heon Kim, Dong Wook Shin, Hyun Lee   +6 more
wiley   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Reduced Mitochondrial Adenine Nucleotide Translocase 1 (ANT1) Correlates With Aging-Associated Airway Remodeling. [PDF]

Aging Cell
Jha R, Shi J, Sedgwick MJ, Sui J, Corcoran TE, Kliment CR.   +5 more
europepmc   +1 more source

Advancing collagen‐related pathology assessment through second‐harmonic generation imaging

Journal of Microscopy, EarlyView.
Abstract Collagen remodelling and dysregulation are the hallmarks of diverse pathological conditions. In this context, second‐harmonic generation (SHG) imaging has emerged as a powerful label‐free modality for assessing collagen. This offers submicron resolution, intrinsic optical sectioning, and deeper imaging capabilities without the need for ...
Jackson Rodrigues, Manikanth Karnati, Gagan Raju, Edwin Pious, Ankur Gogoi, Guan‐Yu Zhuo, Nirmal Mazumder, Fu‐Jen Kao   +7 more
wiley   +1 more source

Obesity Modifies Sphingolipid Signatures in Childhood Asthma

Clinical &Experimental Allergy, EarlyView.
Harshita Shailesh, Alaa Abdelhamid, Ahmed Arabi, Yaman Al‐Haneedi, Shana Jacob, Giridhara Rathnaiah Babu, Stefan Worgall, Ibrahim Janahi   +7 more
wiley   +1 more source

Assessing mature and immature collagen in tonsillar tissue using second harmonic generation microscopy

Journal of Microscopy, EarlyView.
Abstract Recurrent tonsillitis (RT) and obstructive sleep apnoea (OSA) are major indications for tonsillectomy, yet their tissue‐level pathology remains unclear. Recurrent inflammation in RT may induce collagen remodelling through excess extracellular matrix deposition.
Kay Polland, Megan Clapperton, Thushitha Kunanandam, Catalina D Florea, Catriona M Douglas, Gail McConnell   +5 more
wiley   +1 more source

Pathogenic Cell in COPD: Mechanisms of Airway Remodeling, Immune Dysregulation, and Therapeutic Implications. [PDF]

Int J Chron Obstruct Pulmon Dis
Zhou K, Wen Q, Zuo Y, Bai G, Sun R.
europepmc   +1 more source

The Sound Environment in the PICU: A Scoping Review Describing Sound Levels, Interventions and Patient Impacts

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Elevated sound levels are associated with increased morbidity in adult and neonatal intensive care; however, their impact in the paediatric intensive care unit (PICU) remains poorly characterised. The aim of this scoping review was to characterise sound exposure in the PICU, including its measurement, sources, and associations with patient ...
Janeen Bower, Hazel Low, Naomi Khan, Sebastian J. Corlette, Emma Macdonald‐Laurs, Andrea Veysey, Ben Gelbart, Kate Masterson   +7 more
wiley   +1 more source