Results 61 to 70 of about 77,336 (300)
Advanced Science, EarlyView.We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang +9 more
wiley +1 more source
Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma
Cells, 2022 Genome-wide association studies (GWAS) have shown that variants of patched homolog 1 (PTCH1) are associated with lung function abnormalities in the general population.
Anthony Tam +13 more
doaj +1 more source
IgE induces proliferation in human airway smooth muscle cells: role of MAPK and STAT3 pathways [PDF]
, 2013 Airway remodeling is not specifically targeted by current asthma medications, partly owing to the lack of understanding of remodeling mechanisms, altogether posing great challenges in asthma treatment.
Al-Subait, Duaa +6 more
core +2 more sources
RIPK3 Orchestrates Scar‐Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis
Advanced Science, EarlyView.Beyond signaling cell death, RIPK3 emerges as a critical metabolic regulator in pulmonary fibrosis. This research reveals that RIPK3 promotes PI3K‐AKT signaling in scar‐associated macrophages to fuel polyamine synthesis, independent of its kinase activity.
Tao Yang +12 more
wiley +1 more source
Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling
Nature Communications, 2023 Dysregulation of IL-17A is closely associated with airway inflammation and remodeling in severe asthma. However, the molecular mechanisms by which IL-17A is regulated remain unclear.
Jingyun Quan +19 more
doaj +1 more source
Clinical relevance of airway remodelling in airway diseases [PDF]
European Respiratory Journal, 2007 Asthma and chronic obstructive pulmonary disease (COPD) are characterised by airflow obstruction, airway remodelling (measurable structural change) and inflammation. The present review will examine the relationship between airway remodelling in these two conditions with respect to symptoms, abnormal lung function, airway hyperresponsiveness and decline
A L, James, S, Wenzel
openaire +2 more sources
Macrophage Extracellular Traps in Immunity and Cancer
Advanced Science, EarlyView.As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li +5 more
wiley +1 more source
Frontiers in Microbiology, 2013 Asthma is a serious health and socioeconomic issue all over the world, affecting more than 300 million individuals. The disease is considered as an inflammatory disease in the airway, leading to airway hyperresponsiveness, obstruction, mucus hyper ...
Makoto eKudo +2 more
doaj +1 more source
Pathway reconstruction of airway remodeling in chronic lung diseases: a systems biology approach. [PDF]
PLoS ONE, 2014 Airway remodeling is a pathophysiologic process at the clinical, cellular, and molecular level relating to chronic obstructive airway diseases such as chronic obstructive pulmonary disease (COPD), asthma and mustard lung.
Ali Najafi +5 more
doaj +1 more source
Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways [PDF]
, 2014 The mechanisms for the development of bronchiectasis and airway hyperreactivity have not been fully elucidated. Although genetic, acquired diseases and environmental influences may play a role, it is also possible that motile cilia can influence this ...
Amria, May +17 more
core +1 more source