Results 121 to 130 of about 1,534,638 (251)

Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals

Integrative Zoology, EarlyView.
This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong, Chunxu Wang, Enqing Pei, Liang Zhao, Simin Chai, Ran Tian   +5 more
wiley   +1 more source

Airway smooth muscle pathology in Pompe Disease

, 2016
Pompe disease is a rare autosomal recessive disease which results from a deficiency of acid α-glucosidase (GAA) - an enzyme that degrades lysosomal glycogen. Patients with Pompe disease develop intra-lysosomal accumulation of glycogen in multiple tissues
Xiong, Lang, Lui, Donghai, Zhuge, Ronghua, Keeler, Allison M, Desrochers, Kaitlyn, Elmallah, Mai K.   +5 more
core   +1 more source

Differential Roles for IL‐4Rα and IL‐13Rα1 in Immune Cell Infiltration and Epithelial Remodeling in Experimental Eosinophilic Gastritis

Allergy, EarlyView.
This study described the development of an experimental model for eosinophilic gastritis (EoG). Experimental EoG recapitulates histopathological features of human disease. including foveolar elongation, fibrosis, eosinophilia, mastocytosis and shared transcriptional programs.
Anish Dsilva, Shraddha Sharma, Shireen Barakey, Ariel Wagner, Alice Keisar, Tali Bar‐on, Michal Itan, Ariel Munitz   +7 more
wiley   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling

, 2020
HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle ...
A Ullah (13375230), RJ Steptoe (14458038), Z Loh (13371966), SB Mazzone (14458035), E Porrello (13375239), K Lane (9875315), WJ Gan (14458023), AA Sikder (14458029), PD Sly (14453628), JP Lynch (11118801), MB Sukkar (14458041), S Phipps (13370940), KM Spann (14457480), RB Werder (14458026), JW Upham (14458044), V Zhang (13370919), J Simpson (8412294), CB Sim (14458032)   +17 more
core  

Pathogenic Airway Bacteria and Local Immune Responses During Early‐Life Asthma‐Like Episodes

Allergy, EarlyView.
This study investigates how Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis associate with airway immune responses during early‐life asthma‐like episodes, and compare these responses between children with and without asthma.
Mathilde Bundgaard Svendsen, Tamo Sultan, Anton Kjellberg, Mathias Melgaard, Susanne Brix, Karen Krogfelt, Nilo Vahman, Ann‐Marie Malby Schoos, Jakob Stokholm, Bo Lund Chawes, Klaus Bønnelykke, Jonathan Thorsen, Julie Nyholm Kyvsgaard   +12 more
wiley   +1 more source

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

Peri‐operative management of patients having day surgery: a consensus statement from the Association of Anaesthetists, British Association for Day Surgery and the Association of Paediatric Anaesthetists, Great Britain and Ireland

Anaesthesia, EarlyView.
Summary Introduction Day surgery is now recognised widely as being a vital component of modern healthcare delivery with overall day surgery rates in the UK now > 85%. Day surgery offers an enhanced experience for patients with reduced risk of postoperative complications (e.g.
Craig R. Bailey, David Bunting, Lindsay Hudman, Shivan Kanani, Kirstin May, Catalina Stendall, Rachel Tibble, Allan Xu, Matthew D. Wiles   +8 more
wiley   +1 more source

Airway Smooth Muscle: A New Target in the Treatment of Irreversible Airflow Obstruction in Asthma?

, 2014
Objectives: 1. Obtain a better understanding of irreversible airflow obstruction in asthma 2. Focus on processes that mediate glucocorticoid insensitivity 3.
Panettieri, Jr., M.D, Reynold A.
core   +1 more source

Supplementary file for Downregulation of protein phosphatase 2Aα in asthmatic airway smooth muscle

Supplementary file for Downregulation of protein phosphatase 2Aα in asthmatic airway smooth ...
Rodney D Britt Jr (18165865), Christina Pabelick (13599453), YS Prakash (18165870), Ashish Kumar (18165864), Mohammad Irshad Reza (18165861), Venkatachalem Sathish (9389855)   +5 more
core   +1 more source